Development of composite carbon quantum dots-insulin formulation for oral administration

Camlik, Gamze; Özakça, Işıl; Bilakaya, Besa; Özçeli̇kay, A.Tanju; Velaro, Adrian Joshua; Wasnik, Siddhanshu; Değim, İsmail Tuncer

doi:10.1016/j.jddst.2022.103833

Cited by 11 publications

(10 citation statements)

References 49 publications

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“…Nanomaterials offer unique properties that arise from working at the nanoscale and are often used in medicine to provide a qualitative leap in therapy [ 61 ]. Among nanoparticles (NPs), those studied against insulin fibrillation include silicon NPs [ 62 ], ceria NPs [ 63 ], magnetite NPs [ 64 ], gold NPs [ 65 ], silver NPs [ 66 ], graphene oxide [ 67 ], organic NPs [ 68 ], carbon dots [ 69 , 70 , 71 ], and quantum dots [ 72 ]. Among molecules, there are glycopolymers [ 73 , 74 ], amphiphiles [ 75 ], aromatic molecules [ 76 ], polyphenols [ 6 , 77 , 78 ], vitamins [ 79 ], dyes [ 80 ], and various drugs [ 81 ].…”

Section: Peptide Inhibitors Of Insulin Fibrillationmentioning

confidence: 99%

Peptide Inhibitors of Insulin Fibrillation: Current and Future Challenges

Rosetti

Marchesan

2023

IJMS

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Amyloidoses include a large variety of local and systemic diseases that share the common feature of protein unfolding or refolding into amyloid fibrils. The most studied amyloids are those directly involved in neurodegenerative diseases, while others, such as those formed by insulin, are surprisingly far less studied. Insulin is a very important polypeptide that plays a variety of biological roles and, first and foremost, is at the basis of the therapy of diabetic patients. It is well-known that it can form fibrils at the site of injection, leading to inflammation and immune response, in addition to other side effects. In this concise review, we analyze the current knowledge on insulin fibrillation, with a focus on the development of peptide-based inhibitors, which are promising candidates for their biocompatibility but still pose challenges to their effective use in therapy.

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Section: Peptide Inhibitors Of Insulin Fibrillationmentioning

confidence: 99%

Peptide Inhibitors of Insulin Fibrillation: Current and Future Challenges

Rosetti

Marchesan

2023

IJMS

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“…Camlik et al prepared nitrogen‐containing CQDs, combined them with monomeric insulin, and decorated the conjugate with methylcellulose (MC) as well as PEG for administration via oral route. The oral administration in experimental animals was reported to lower the blood sugar levels and from the studies, insulin loading, release, and kinetics of insulin release were reported (Camlik et al, 2022). Karami et al utilized a hydrogel nanocarrier featuring Chitosan, γ‐Al 2 O 3 , and CQDs, developed via the double nanoemulsion technique, to selectively release curcumin as a template drug to treat breast cancer tissue.…”

Section: Carbon Quantum Dots In Drug Deliverymentioning

confidence: 99%

“…release, and kinetics of insulin release were reported(Camlik et al, 2022).Karami et al utilized a hydrogel nanocarrier featuring Chitosan, γ-Al 2 O 3 , and CQDs, developed via the double nanoemulsion technique, to selectively release curcumin as a template drug to treat breast cancer tissue. The synergistic implication of γ-Al 2 O 3 , and…”

mentioning

confidence: 99%

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Das,

Roy,

Saha

2024

Biotech & Bioengineering

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The carbon‐based nanostructures have led to the development of theranostic nanoplatforms for simultaneous diagnosis and therapy due to their effective cell membrane‐penetration ability, low degree of cytotoxicity, excellent pore volume, substantial chemical stability, and reactive surface. In the last few years, extensive efforts were made to design multifunctional nanoplatform strategies based on carbon nanostructures, involving multimodal imaging, controlled drug release capabilities, sensing in vitro, efficient drug loading capacity, and therapy. Carbon and graphene quantum dots (CQDs and GQDs) were the recent entrants, contingently being assessed for drug delivery and bioimaging. With the advancements, these quantum dots have ignited remarkable research interest and are now widely evaluated for diagnosis, bioimaging, sensing, and drug delivery applications. The last decade has witnessed their remarkable electrical, optical, and biocompatible properties since their inception. It is presumed that both of them have high potential as drug carriers and would serve as the next generation of approaches to address numerous unresolved therapeutic challenges. This review examined the recent advances of CQD and GQD based drug delivery applications, challenges, and future perspectives to pave the way for further studies in the future.

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“…Many successful studies reported that splendid oral antihyperglycemic drugs can be developed with the help of new nanocarriers like quantum dots . Still, there are some challenges associated with oral insulin treatment.…”

Section: Introductionmentioning

confidence: 99%

“…4 Many successful studies reported that splendid oral antihyperglycemic drugs can be developed with the help of new nanocarriers like quantum dots. 5 Still, there are some challenges associated with oral insulin treatment. The low bioavailability in the intestine has been cited as the critical factor that blocks the development of oral delivery systems for insulin drugs.…”

Section: Introductionmentioning

confidence: 99%

Net-Neutral Nanoparticles-Extruded Microcapsules for Oral Delivery of Insulin

Liu

Xue

et al. 2023

ACS Appl. Mater. Interfaces

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Oral delivery of insulin could widely improve the quality of life of diabetic patients but still requires further exploration. Commonly utilized oral delivery vehicles hardly penetrate the intestinal mucus barrier, thus greatly hurdling their therapeutic efficacy. State-of-the-art technology shows that coating particles with neutral surface charge could reduce adsorption of mucins and improved the transport of particles within mucus. However, the synthesis of net-neutral particles (NNs) usually need complex purification and processing procedure. Herein, the NNs were conveniently constructed by simply adjusting the ratio of positive (chitosan) and negative (γ-glutamic acid) materials. To further achieve the optimal bioavailability of NNs, NNs formed materials were package in to wild chrysanthemum pollens, obtaining pH-triggered nanoparticles-extruding microcapsules (PNMs@insulin). At the small intestine pH value (∼6.0), the amino groups of CS deprotonate gradually and trigger the swelling, followed by the rapid extrusion of NNs through nano-orifices on the pollens' surface. After oral administration of the microcapsules, plasma insulin levels were enhanced significantly with a high oral bioavailability of >40%, leading to a remarkable and longer-sustained blood glucose-reducing effect. Moreover, we discovered that the empty pollen shells could act as a potential saccharide-adsorbing agent, which helps to manage sugar intake. This oral strategy of insulin will provide a vast potential for daily and facile diabetes treatment.

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Development of composite carbon quantum dots-insulin formulation for oral administration

Cited by 11 publications

References 49 publications

Peptide Inhibitors of Insulin Fibrillation: Current and Future Challenges

Peptide Inhibitors of Insulin Fibrillation: Current and Future Challenges

Recent advances in biomedical applications of carbon and graphene quantum dots: A review

Net-Neutral Nanoparticles-Extruded Microcapsules for Oral Delivery of Insulin

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