Development of Clinical Dosage Forms for a Poorly Water-Soluble Drug II: Formulation and Characterization of a Novel Solid Microemulsion Preconcentrate System for Oral Delivery of a Poorly Water-Soluble Drug

Application of Melt Granulation Technology Using Twin-screw Extruder in Development of High-dose Modified-Release Tablet Formulation

“…32 CRM has been reported to be a beneficial tool for characterization of solid dosage forms, 33-35 semisolid formulations, 36,37 inhalation compositions [38][39][40] and of coated stents. 41 Haefele and Paulus 42 have recently reviewed the application of CRM in the analysis of drug substances and drug products that may include visual appearance (morphology, particle size, particle size distribution, and surface roughness), content uniformity (composition, distribution, and homogeneity), chemical identity (structure and stability), and physical state (solid state, polymorphism, crystallinity, and phase transformations).…”

Multicomponent Amorphous Nanofibers Electrospun from Hot Aqueous Solutions of a Poorly Soluble Drug

“…Nanoparticle-based drug delivery systems (DDS) reported in the literature include nanocrystalline particles and nanosuspensions of pure drugs (usually prepared by direct nanosizing of the drug particles), nanoparticles, solid lipid nanoparticles, microemulsions, micelles and nanoencapsulations (often the drugs are distributed in a nano complex and are prepared by co-nanosizing of the drugs with functional pharmaceutical excipients such as polymer, surfactants, phospholipids, etc.) (9)(10)(11)(12). Although in the past few years formulating poorly water-soluble compounds using a nanoparticle approach has been attempted, there is a growing need for more effective and versatile ways to handle formulation issues associated with poorly watersoluble molecules (13,14).…”

Thorough characterization of a Self-Emulsifying Drug Delivery System with Raman hyperspectral imaging: A case study

“…This implies that most NCE show a poor water solubility (Li et al, 2009) and are classified as BCS class 2 (poor solubility and high permeability). However, the main problem with BCS class 2 drugs is that they exhibit relatively poor bioavailability.…”