Development of Cleft Lip and Palate

Chadha, Ambika; Cobb, Alistair

doi:10.1007/978-3-319-26158-4_13

Clinical Embryology 2019

DOI: 10.1007/978-3-319-26158-4_13

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Development of Cleft Lip and Palate

Ambika Chadha

Alistair Cobb

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2024

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Cited by 2 publications

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“…4 The aetiology of the cleft lip is associated with genetic predisposition and environmental factors, which disturb proper fetal development. The main environmental risk factors of CLP include alcohol or drug abuse during pregnancy, lack of folic acid, 5 nutritional deficiencies, maternal age less than 20 or older than 35 years, 2 inter-pregnancy periods of less than 2 years, consanguinity, the use of certain drugs during pregnancy, including anticonvulsants and anticoagulants, 6 as well as exposure to infections during pregnancy, such as toxoplasmosis, rubella, cytomegalovirus, and herpes virus. 7 Cleft lip repair surgery is commonly performed within the first few months of birth.…”

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confidence: 99%

In‐vivo assessment of application of folinic acid and botulinum toxin A in cleft lip surgical defects

Shiva,

Soltani,

Moaddabi

et al. 2024

Orthod Craniofacial Res

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IntroductionFolinic acid and botulinum toxin A have shown promising results in wound healing in different studies. This study aimed to compare the effects of these approaches on wound healing after simulating cleft lip surgery in rats.MethodsIn this experimental animal study, after creating lip defects, 30 rats were randomly divided into three groups and received normal saline (CTL), botulinum toxin A (BOT), and folinic acid (FOL). Biopsy from the skin wounds was performed after 14‐ and 28‐days. These samples were stained with haematoxylin and eosin and Masson trichrome staining. Finally, each pathological parameter of wound healing was rated in this study.ResultsWhile the inflammatory response was not different among the study groups, fibroblast proliferation and collagen deposition were significantly higher in FOL group compared to BOT group. Moreover, both BOT and FOL facilitated epithelial healing and 14‐day angiogenesis as compared with normal saline.ConclusionsImproved wound healing was observed using both botulinum toxin A and folinic acid in rat animal models. However, the application of botulinum toxin A caused less fibroblast proliferation and collagen deposition which can potentially lead to less scar formation, which can be particularly important in the aesthetic zone.

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confidence: 99%

In‐vivo assessment of application of folinic acid and botulinum toxin A in cleft lip surgical defects

Shiva,

Soltani,

Moaddabi

et al. 2024

Orthod Craniofacial Res

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Cerebro-oculo-nasal syndrome, a congenital anomaly: A rare case report

Anzali

Talebiazar

Goli

et al. 2022

International Journal of Surgery Open

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Introduction and importance The most common congenital defect involving the face and jaws is cleft lip and palate. Exactly where they appear is determined by the locations at which fusion of the various facial processes failed to occur. The lip or the lip and palate together fail to close in approximately 1–1.5 in every 1000 babies born. Case presentation The present case report is of a 36-week- and 4-day-old male fetus with a birth weight of 2100 gr, a height of 41 cm, and a head circumference of 35 cm. He was born to a 42-year-old mother by Cesarean section at Kosar Obstetrics and Gynecology Hospital, Urmia, Iran. In the initial physical examination, hydrocephalus, eye abnormalities, cleft lip, and cleft palate were observed. Unfortunately, the newborn expired two days after birth. Clinical discussion The main characteristics of this syndrome are mental retardation, anophthalmia or microphthalmia, abnormal nostrils, and disorders of the central nervous system. Conclusion Early diagnosis during pregnancy using diagnostic methods and proper management of this abnormality should be strongly emphasized to prevent further harm to the newborn and the mother with this syndrome. Highlights

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Development of Cleft Lip and Palate

Cited by 2 publications

References 9 publications

In‐vivo assessment of application of folinic acid and botulinum toxin A in cleft lip surgical defects

In‐vivo assessment of application of folinic acid and botulinum toxin A in cleft lip surgical defects

Cerebro-oculo-nasal syndrome, a congenital anomaly: A rare case report

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