Development of Chorea with Lupus Anticoagulant after Interferon Therapy

Jp, Néau; Guilhot, Joëlle; Boinot, C.; Dumas, P; Am, Tantot; R, Gil

doi:10.1159/000117257

Cited by 10 publications

(7 citation statements)

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“…In our opinion, these two findings are independent, because no association between LA and CML has ever been reported. Some authors have reported the appearance of LA after immunotherapy with IF, 19 but our patient received HU as cytotoxic treatment, and an association between LA and HU has also never been reported.…”

Section: Discussionmentioning

confidence: 61%

Disappearance of lupus anticoagulant after allogeneic bone marrow transplantation

Olalla

Ortín

Hermida

et al. 1998

Bone Marrow Transplant

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Summary:Lupus anticoagulant antibodies have never been reported to disappear after either allogeneic or autologous bone marrow transplantation in humans. We report the first case of disappearance of lupus anticoagulant antibodies in a patient without systemic lupus erythematosus or clinical evidence of other autoimmune disorders, who received an allogeneic bone marrow transplant as treatment for chronic myeloid leukemia. Although marrow transplantation is not a recognized therapy for antiphospholipid syndrome, our observation should be considered another example of the capability of intensive chemo-radiotherapy followed by stem cell transplantation to ablate a pathologic marrow clone resulting in an autoimmune disorder and improve, or even cure, some severe autoimmune diseases.

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Section: Discussionmentioning

confidence: 61%

Disappearance of lupus anticoagulant after allogeneic bone marrow transplantation

Olalla

Ortín

Hermida

et al. 1998

Bone Marrow Transplant

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“…In addition, α‐interferon may also induce movement disorders such as chorea or dyskinesias 38, 39. The development of chorea in a young woman treated by interferon α‐2a for chronic myelogenous leukaemia has been described38; however, the direct responsibility of interferon in the chorea genesis may be discussed as this patient also presented lupus anticoagulant.…”

Section: Discussionmentioning

confidence: 88%

Atypical propriospinal myoclonus with possible relationship to α interferon therapy

et al. 2003

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We report on a man who received interferon-alpha 2a therapy for kidney cancer and who subsequently developed propriospinal myoclonus. The myoclonus was noted at rest and during movement. The jerks were reinforced by cutaneous stimuli and tendon taps and spread to the spinal cord via polysynaptic propriospinal pathways. Cerebrospinal fluid analysis, spinal cord magnetic resonance imaging, electroencephalogram with back-averaging, and somatosensory-evoked potentials were normal. No antineuronal antibodies were found. Although the mechanism of interferon neurotoxicity remains unclear, the possible responsibility of interferon was considered, as no focal lesion or paraneoplastic pathology were disclosed.

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“…Another possible mechanism might involve microvascular lesions that result from vasculitis or vasospasm, because there is evidence of IFN-α-induced retinal abnormalities, including ischemic lesions, cotton wool exudate, capillary occlusion or retinal hemorrhage [15,16] . To the best of our knowledge, four cases of chorea, associated with IFN-α were have been reported in the literature so far [17][18][19][20] . These were not associated with HD.…”

Section: Discussionmentioning

confidence: 99%

Bell’s palsy and choreiform movements during peginterferon α and ribavirin therapy

Barut¹,

Karaer²,

Öksüz³

et al. 2009

WJG

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Neuropsychiatric side effects of long-term recombinant interferon-α therapy consist of a large spectrum of symptoms. In the literature, cranial neuropathy, especially Bell's palsy, and movement disorders, have been reported much less often than other neurotoxic effects. We report a case of Bell's palsy in a patient with chronic hepatitis C during peginterferon-α and ribavirin therapy. The patient subsequently developed clinically inapparent facial nerve involvement on the contralateral side and showed an increase in choreic movements related to Huntington's disease during treatment.

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Development of Chorea with Lupus Anticoagulant after Interferon Therapy

Cited by 10 publications

References 0 publications

Disappearance of lupus anticoagulant after allogeneic bone marrow transplantation

Disappearance of lupus anticoagulant after allogeneic bone marrow transplantation

Atypical propriospinal myoclonus with possible relationship to α interferon therapy

Bell’s palsy and choreiform movements during peginterferon α and ribavirin therapy

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