Development of chitosan–pullulan composite nanoparticles for nasal delivery of vaccines:<i>in vivo</i>studies

Cevher, Erdal; Salomon, Stefan; Somavarapu, Satyanarayana; Brocchini, Steve; Alpar, H. Oya

doi:10.3109/02652048.2015.1073393

Cited by 30 publications

(9 citation statements)

References 72 publications

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“…Similarly natural polymeric nanoparticles were used in different diseases, including Inulin: ADVAX™ in Anthrax [ 76 ]; Listeria monocytogenes [ 77 ], Influenza virus [ 78 ], SARS-CoV [ 79 ], HBV [ 80 ], HIV, and JVE-WNV [ 81 ]. Alginate and pullulan composed nanoparticles used in various microbial diseases that are caused by Klebsiella pneumoniae [ 82 ], Pseudomonas aeruginosa [ 83 ], and Influenza virus [ 84 ], Difteria [ 85 ]. Similarly polymeric nanoparticles composed of chitosan were used in various microbiological diseases caused by E. coli O157:H7 [ 86 ], P. aeruginosa [ 87 ], Influenza virus [ 74 ], HBV [ 88 ], Filariasis [ 89 ], and Dengue [ 90 ].…”

Section: Types Of Various Nanomaterials Used In Veterinary Medicinmentioning

confidence: 99%

Theranostics Aspects of Various Nanoparticles in Veterinary Medicine

Bai

Lin

Huang

et al. 2018

IJMS

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Nanoscience and nanotechnology shows immense interest in various areas of research and applications, including biotechnology, biomedical sciences, nanomedicine, and veterinary medicine. Studies and application of nanotechnology was explored very extensively in the human medical field and also studies undertaken in rodents extensively, still either studies or applications in veterinary medicine is not up to the level when compared to applications to human beings. The application in veterinary medicine and animal production is still relatively innovative. Recently, in the era of health care technologies, Veterinary Medicine also entered into a new phase and incredible transformations. Nanotechnology has tremendous and potential influence not only the way we live, but also on the way that we practice veterinary medicine and increase the safety of domestic animals, production, and income to the farmers through use of nanomaterials. The current status and advancements of nanotechnology is being used to enhance the animal growth promotion, and production. To achieve these, nanoparticles are used as alternative antimicrobial agents to overcome the usage alarming rate of antibiotics, detection of pathogenic bacteria, and also nanoparticles being used as drug delivery agents as new drug and vaccine candidates with improved characteristics and performance, diagnostic, therapeutic, feed additive, nutrient delivery, biocidal agents, reproductive aids, and finally to increase the quality of food using various kinds of functionalized nanoparticles, such as liposomes, polymeric nanoparticles, dendrimers, micellar nanoparticles, and metal nanoparticles. It seems that nanotechnology is ideal for veterinary applications in terms of cost and the availability of resources. The main focus of this review is describes some of the important current and future principal aspects of involvement of nanotechnology in Veterinary Medicine. However, we are not intended to cover the entire scenario of Veterinary Medicine, despite this review is to provide a glimpse at potential important targets of nanotechnology in the field of Veterinary Medicine. Considering the strong potential of the interaction between the nanotechnology and Veterinary Medicine, the aim of this review is to provide a concise description of the advances of nanotechnology in Veterinary Medicine, in terms of their potential application of various kinds of nanoparticles, secondly we discussed role of nanomaterials in animal health and production, and finally we discussed conclusion and future perspectives of nanotechnology in veterinary medicine.

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Section: Types Of Various Nanomaterials Used In Veterinary Medicinmentioning

confidence: 99%

Theranostics Aspects of Various Nanoparticles in Veterinary Medicine

Bai

Lin

Huang

et al. 2018

IJMS

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“…Nanoparticles (NPs) of chitosan and trimethyl chitosan (TMC) are considered as one of the most attractive nasal delivery systems as it offers safety, biodegradability, biocompatibility, mucoadhesion, penetration enhancement and adjuvanticity [ 6 , 7 ]. Therefore, chitosan and TMC NPs have recently been used in the development of vaccines through nasal applications [ 8 – 12 ]. These NPs elicit strong immune response as shown by the significant increase in circulating antibody and the titer of secretory IgA in nasal washes [ 11 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Responses of primary human nasal epithelial cells to EDIII-DENV stimulation: the first step to intranasal dengue vaccination

Nantachit

Sunintaboon

Ubol

2016

Virol J

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BackgroundAbout half of the world’s population are living in the endemic area of dengue viruses implying that a rapid-mass vaccination may be required. In addition, a major target of dengue vaccine are children, thus, a needle-free administration is more attractive. These problems may be overcome by the alternative route of vaccination such as topical, oral and intranasal vaccination. Here, we investigated the possibility to deliver a dengue immunogen intranasally, a painless route of vaccination. The tested immunogen was the domain III of dengue serotype-3 E protein (EDIII-D3) loaded into trimethyl chitosan nanoparticles (EDIII-D3 TMC NPs). The primary human nasal epithelial cells, HNEpCs, were used as an in vitro model for nasal responses.ResultsAt tested concentrations, EDIII-D3 TMC NPs not only exerted no detectable toxicity toward HNEpC cultures but also efficiently delivered EDIII-D3 immunogens into HNEpCs. Moreover, HNEpCs quickly and strongly produced proinflammatory cytokines (IL-1β, IL-6, TNF-α), type-I IFN, the growth factors (GM-CSF, IL-7), the chemokines (MCP-1, MIP-1β, IL-8), Th1-related cytokines (IL-2, IL-12p70, IL-17, IFN-γ) and Th2-related cytokine (IL-4) in response to EDIII-D3 TMC NPs treatment.ConclusionsA potential mucosal delivery system for dengue immunogens was revealed and found to stimulate a strong local innate antiviral response which possibly leading to a systemic adaptive immunity.

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“…44 PL hydrogel NPs have been employed for gene delivery 67 or as composite with CS for vaccine delivery. 68,69 Recently, PL was utilised as block in double hydrophilic block copolymers, which were utilised in turn for self-assembly, for example in the formation of completely hydrophilic capsules, 70 droplets 71,72 or particles. 73 Similar to DEX-based NPs, PL-based NPs (PLNPs) can be prepared by self-assembly after the hydrophobic modification of PL.…”

Section: Pullulanmentioning

confidence: 99%