Development of Chemical Synthesis Methods Based on Fusion of Inorganic and Organic Chemistry for Ceramic Powder Preparation and Surface Modification Methods of Nanoparticles and Nanosheets

Abstract

Preparation methods for ceramic powders and surface modification methods of ceramic nanoparticles and nanosheets have been developed by combining knowledges and techniques inorganic chemistry and organic chemistry. Preparation of non-oxide ceramic powers by the use of inorganic and organometallic polymers as preceramic precursors has been developed for aluminum nitride and its composites using cage-type compounds with Al-N backbones. The use of preceramic precursors can also provide amorphous materials, whose use can realize the crystallization of high-pressure phases of metal nitrides under milder conditions. The preparation methods of metal oxide nanoparticles from metal chlorides using oxygen donors have also been developed for TiO 2 and Fe 3 O 4 . In addition, surface modification methods for metal oxide nanomaterials have been developed. It was demonstrated that the use of liquid-liquid biphasic systems was effective for surface modification of metal oxide nanoparticles and nanosheets. Surface modification of metal oxide nanosheets can also be achieved in a biphasic laminar flow in a microchannel. The development of regioselective surface modification of nanosheets using potassium hexaniobate trihydrate has realized the preparation of Janus nanosheets by using its unique structure. These achievements demonstrate the advantages of the combination of the methods of inorganic and organic chemistry for preparation of ceramic powders and their surface modification.

Surface Modification of Metallic Nanoparticles for Targeting Drugs

“…In nanoparticle-based drug delivery, two main targeting strategies are commonly employed: passive targeting and active targeting. Passive targeting relies on the EPR effect, whereby nanoparticles extravasate through leaky tumor vasculature and accumulate in the tumor interstitium [66]. The aberrant architecture of the tumor neovasculature results in increased vascular permeability compared to normal tissues, enabling nanoparticle accumulation.…”