Development of cardiac parasympathetic neurons, glial cells, and regional cholinergic innervation of the mouse heart

Fregoso, Santiago P.; Hoover, Donald B.

doi:10.1016/j.neuroscience.2012.06.061

Cited by 28 publications

(24 citation statements)

References 35 publications

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“…). Parasympathetic neurons and surrounding satellite glial cells mature postnatally in rodents, and the neurons double in size as they develop connections with the myocardium (Fregoso & Hoover, ). The rodent sympathetic–cardiac circuit is established in the late prenatal and early postnatal period as growing sympathetic fibres innervate the developing heart (Hildreth et al .…”

Section: Neural–cardiac Interactions: Co‐maturation In Developmentmentioning

confidence: 99%

“…The anlagen of cardiac parasympathetic ganglia first appear around the middle of embryonic development in rodents, and vagal input is already present as the immature neurons migrate to positions at the dorsal atrium (Hildreth et al 2009). Parasympathetic neurons and surrounding satellite glial cells mature postnatally in rodents, and the neurons double in size as they develop connections with the myocardium (Fregoso & Hoover, 2012). The rodent sympathetic-cardiac circuit is established in the late prenatal and early postnatal period as growing sympathetic fibres innervate the developing heart (Hildreth et al 2009).…”

Section: Neural-cardiac Interactions: Co-maturation In Developmentmentioning

confidence: 99%

See 1 more Smart Citation

Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease

Habecker

Anderson²,

Birren

et al. 2016

The Journal of Physiology

112

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The nervous system and cardiovascular system develop in concert and are functionally interconnected in both health and disease. This white paper focuses on the cellular and molecular mechanisms that underlie neural-cardiac interactions during development, during normal physiological function in the mature system, and during pathological remodelling in cardiovascular disease. The content on each subject was contributed by experts, and we hope that this will provide a useful resource for newcomers to neurocardiology as well as aficionados.

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Section: Neural–cardiac Interactions: Co‐maturation In Developmentmentioning

confidence: 99%

Section: Neural-cardiac Interactions: Co-maturation In Developmentmentioning

confidence: 99%

Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease

Habecker

Anderson²,

Birren

et al. 2016

The Journal of Physiology

112

View full text Add to dashboard Cite

show abstract

“…Mural cells (pericytes and SMCs) are essential components of vasculature 16,17 , but tools have been lacking for precise isolation of these cells by flow cytometry. Similarly, although Schwann cells are known to be present in the heart 18 , flow cytometric approaches to isolate these cells are limited. Commonly used markers including Cspg4 (also called NG2), Pdgfrb and Mcam are relatively non-specific ( Fig 3A);…”

Section: Skelly Et Al Cardiac Cellular Diversitymentioning

confidence: 99%

“…Expression of Ngf and Ntf3 by cardiac pericytes highlights their potentially important role in development of the autonomic nervous system in the heart. Moreover, cardiac Schwann cells, the myelin-producing cells of the peripheral nervous system, are a discrete cardiac cell population 18 . Thus, multiple cardiac cell types contribute to supporting the development, maintenance, and signal transduction of autonomic nerves.…”

Section: Skelly Et Al Cardiac Cellular Diversitymentioning

confidence: 99%

Single cell transcriptional profiling reveals cellular diversity, communication, and sexual dimorphism in the mouse heart

et al. 2017

Preprint

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INTRODUCTORY PARAGRAPHCharacterization of the cardiac cellulome—the network of cells that form the heart—is essential for understanding cardiac development and normal organ function, and for formulating precise therapeutic strategies to combat heart disease. Recent studies have challenged assumptions about both the cellular composition1 and functional significance of the cardiac non-myocyte cell pool, with unexpected roles identified for resident fibroblasts2 and immune cell populations3,4. In this study, we characterized single-cell transcriptional profiles of the murine non-myocyte cardiac cellular landscape using single-cell RNA sequencing (scRNA-Seq). Detailed molecular analyses revealed the diversity of the cardiac cellulome and facilitated the development of novel techniques to isolate understudied cardiac cell populations such as mural cells and glia. Our analyses also revealed networks of intercellular communication as well as extensive sexual dimorphism in gene expression in the heart, most notably demonstrated by the upregulation of immune-sensing and pro-inflammatory genes in male cardiac macrophages. This study offers new insights into the structure and function of the mammalian cardiac cellulome and provides an important resource that will stimulate new studies in cardiac cell biology.

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“…Cardiac Schwann cells parallel the distribution of cholinergic nerve fibers in the adult atria, are also associated with non-cholinergic nerve fibers, increase in abundance in all areas of the myocardium (ventricles and atria) with increasing age, and are also present in the epicardium. They can be detected with S100 IHC (Fregoso and Hoover 2012). …”

Section: Getting To the Heart Of The Mattermentioning

confidence: 99%

Proceedings of the 2016 National Toxicology Program Satellite Symposium

et al. 2016

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The 2016 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri” was held in San Diego, California, at the Society of Toxicologic Pathology’s (STP) 35th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers’ talks, along with select images that were used by the audience for voting and discussion. Some lesions and topics covered during the symposium included malignant glioma and histiocytic sarcoma in the rodent brain; a new statistical method designed for histopathology data evaluation; uterine stromal/glandular polyp in a rat; malignant plasma cell tumor in a mouse brain; Schwann cell proliferative lesions in rat hearts; axillary schwannoma in a cat; necrosis and granulomatous inflammation in a rat brain; adenoma/carcinoma in a rat adrenal gland; hepatocyte maturation defect and liver/spleen hematopoietic defects in an embryonic mouse; distinguishing malignant glioma, malignant mixed glioma and malignant oligodendroglioma in the rat; comparison of mammary gland whole mounts and histopathology from mice; and discussion of the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) collaborations.

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Development of cardiac parasympathetic neurons, glial cells, and regional cholinergic innervation of the mouse heart

Cited by 28 publications

References 35 publications

Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease

Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease

Single cell transcriptional profiling reveals cellular diversity, communication, and sexual dimorphism in the mouse heart

Proceedings of the 2016 National Toxicology Program Satellite Symposium

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