Development of carboxymethyl chitosan-coated zein/soy lecithin nanoparticles for the delivery of resveratrol

Zhang, Xin; Li, Yangjia; Wu, Zeliang; Li, Jie; Li, Junjian; Deng, Shaopo; Liu, Guijin

doi:10.1039/d2fo03180a

Cited by 4 publications

(2 citation statements)

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“…The obtained NPs could change the crystal morphology of docetaxel, increase the dissolution rate of docetaxel, and exhibit sustained release behavior. Zhang et al [ 46 ] further prepared zein-based NPs using this method for loading resveratrol. The NPs had a high zeta potential (−47.7 ± 0.66 mV) and a high encapsulation efficiency (91.32 ± 4.01%).…”

Section: Preparation Of Zein-based Nanocarriers For Anticancer Drug D...mentioning

confidence: 99%

Recent Advances in Zein-Based Nanocarriers for Precise Cancer Therapy

et al. 2023

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Cancer has emerged as a leading cause of death worldwide. However, the pursuit of precise cancer therapy and high-efficiency delivery of antitumor drugs remains an enormous obstacle. The major challenge is the lack of a smart drug delivery system with the advantages of biodegradability, biocompatibility, stability, targeting and response release. Zein, a plant-based protein, possesses a unique self-assembly ability to encapsulate anticancer drugs directly or indirectly. Using zein as a nanotherapeutic pharmaceutic preparation can protect anticancer drugs from harsh environments, such as sunlight, stomach acid and pepsin. Moreover, the surface functionalization of zein is easily realized, which can endow it with targeting and stimulus-responsive release capacity. Hence, zein is an ideal nanocarrier for the precise delivery of anticancer drugs. Combined with our previous research experiences, we attempt to review the current state of the preparation of zein-based nanocarriers for anticancer drug delivery. The challenges, solutions and development trends of zein-based nanocarriers for precise cancer therapy are discussed. This review will provide a guideline for precise cancer therapy in the future.

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Section: Preparation Of Zein-based Nanocarriers For Anticancer Drug D...mentioning

confidence: 99%

Recent Advances in Zein-Based Nanocarriers for Precise Cancer Therapy

et al. 2023

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“…Nanoparticles can be modified to allow delivery of drugs by inhalation, which offers a promising non-invasive therapeutic option for the treatment of LC, such as a nanocomposite system loaded with RES for nebulization, demonstrating higher anti-cancer selectivity index ( Wang et al, 2020 ; Zhang X. et al, 2023 ). Nanocrystalline materials have good atomization properties and are good carriers for local targeted delivery of natural products with poor water solubility to achieve continuous lung delivery ( Lai et al, 2019 ).…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Natural compounds: Wnt pathway inhibitors with therapeutic potential in lung cancer

Shen,

Gao,

et al. 2023

Front. Pharmacol.

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The Wnt/β-catenin pathway is abnormally activated in most lung cancer tissues and considered to be an accelerator of carcinogenesis and lung cancer progression, which is closely related to increased morbidity rates, malignant progression, and treatment resistance. Although targeting the canonical Wnt/β-catenin pathway shows significant potential for lung cancer therapy, it still faces challenges owing to its complexity, tumor heterogeneity and wide physiological activity. Therefore, it is necessary to elucidate the role of the abnormal activation of the Wnt/β-catenin pathway in lung cancer progression. Moreover, Wnt inhibitors used in lung cancer clinical trials are expected to break existing therapeutic patterns, although their adverse effects limit the treatment window. This is the first study to summarize the research progress on various compounds, including natural products and derivatives, that target the canonical Wnt pathway in lung cancer to develop safer and more targeted drugs or alternatives. Various natural products have been found to inhibit Wnt/β-catenin in various ways, such as through upstream and downstream intervention pathways, and have shown encouraging preclinical anti-tumor efficacy. Their diversity and low toxicity make them a popular research topic, laying the foundation for further combination therapies and drug development.

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Carboxymethyl Chitosan-Based Materials in Packaging, Food, Pharmaceutical, and Cosmetics

Rachtanapun,

Jantrawut

et al. 2023

Multifaceted Carboxymethyl Chitosan Derivatives: Properties and Biomedical Applications

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Development of carboxymethyl chitosan-coated zein/soy lecithin nanoparticles for the delivery of resveratrol

Abstract: The objective of this work is to formulate a zein-based nanocomposite for the delivery of natural polyphenols. A proprietary atomizing/antisolvent precipitation (AAP) process was used to prepare carboxymethyl chitosan (CMC)-coated...

Cited by 4 publications

References 53 publications

Recent Advances in Zein-Based Nanocarriers for Precise Cancer Therapy

Recent Advances in Zein-Based Nanocarriers for Precise Cancer Therapy

Natural compounds: Wnt pathway inhibitors with therapeutic potential in lung cancer

Carboxymethyl Chitosan-Based Materials in Packaging, Food, Pharmaceutical, and Cosmetics

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