Development of Capsule containing Immediate Release Tablet and Extended Release Floating Tablet for Monitoring Release of Atenolol

Kolhe, Mahesh; Gilhotra, Ritu; Asane, Govind S.

doi:10.52711/0974-360x.2021.00393

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Following a predetermined time period, the placed samples were assessed for weight variation, hardness, thickness, %drug release and drug content. [28][29][30][31][32][33]…”

Section: Stability Studymentioning

confidence: 99%

Formulation and Evaluation of Bioadhesive Pulsatile Drug Delivery System of an Antihypertensive Drug

Janugade,

Singla

2024

IJPQA

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The current research aimed to prepare and estimate bioadhesive pulsatile drug delivery system (BPDDS) of an antihypertensive drug, losartan potassium, containing the formulation of a fast-dissolving core tablet and a combination of core tablet to polymer coating to formulate (BPDDS) tablet through a direct compression procedure. The coating was completed by utilizing polymers ethyl cellulose and carbopol 934. Pre-compression and post-compression parameters, drug release, lag time and mucoadhesive examination was entirely assessed for the formulations. Altogether, estimation tests were found to be inside parameters. The expected lag time for hypertension is 8 hours; hence this lag time was achieved by using a bioadhesive pulsatile system. The optimized formulation showed 8 hours lag time with appropriate mucoadhesion for an equivalent period. Therefore, the BPDDS was greatest preventative substitute for drug which are the highest absorption in the stomach and for drugs which used to treat diseases with a circadian rhythm.

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“…Following a predetermined time period, the placed samples were assessed for weight variation, hardness, thickness, %drug release and drug content. [28][29][30][31][32][33]…”

Section: Stability Studymentioning

confidence: 99%

Formulation and Evaluation of Bioadhesive Pulsatile Drug Delivery System of an Antihypertensive Drug

Janugade,

Singla

2024

IJPQA

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“…This augmentation significantly extends drug residence in the GIT, thereby enhancing drug absorption and oral bioavailability. 8,9 In the background of research work, we endeavor to formulate a floating drug delivery system for two vital cardiovascular medications, sacubitril and valsartan, with the specific goal of extending the floating time, prolonging stomach residency, and reducing floating lag time. Our approach harnesses the synergistic potential of natural polymers, judiciously selected and utilized in optimal proportions, to enhance the therapeutic activity of these drugs.…”

mentioning

confidence: 99%

In-vitro Evaluation and Optimization of Sacubitril and Valsartan Floating Tablet using Natural Polymer

Goyal,

Kumar

2023

IJDDT

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Oral systems have become gradually extensive for human consumption because of their numerous advantages, such as formulation efficiency, cost-effectiveness, and patient safety compliance. These systems offer a versatile platform for controlled drug release, allowing precise targeting of absorption site in the gastrointestinal tract. Accomplishing ideal therapeutic results for certain medications often requires precise control of drug release at specific locations within the gastrointestinal tract. In this study, our goal was to create a floating drug delivery system for two vital cardiovascular medications, sacubitril and valsartan. Our specific objectives were to extend floating time, prolong stomach residency, and reduce floating lag time. The strategy involved harnessing the synergistic potential of natural polymers in optimal proportions to enhance drug activity. Following the principles of quality by design (QbD), we systematically explored various formulation factors to optimize the drug delivery system. Analysis of tablet characteristics revealed significant variations in key parameters, such as swelling index, floating lag time (FLT), total floating time (TFT), and drug content for both sacubitril and valsartan. The enhanced formulation (F12) stood out with a remarkable swelling index of 93.4%, a floating lag time of 6.7 seconds, and an impressive total floating time of 12 hours. Furthermore, high drug content percentages were achieved, with sacubitril at 98.70% and valsartan at 94.65%. The successful development and optimization of the floating tablet formulation carry substantial clinical implications. The extended gastric retention, controlled drug release, and high drug content of the optimized formulation suggest enhanced bioavailability and therapeutic efficacy for both sacubitril and valsartan. The prolonged total floating time offers convenience to patients, potentially improving medication adherence in managing cardiovascular diseases. In conclusion, this study highlights the formulation and optimization of floating tablets as a noteworthy advancement in drug delivery technology, promising improved therapeutic outcomes and enhanced patient convenience.

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Quantitative analysis of solid dosage forms of Atenolol by Raman spectroscopy

Ali,

Nawaz,

Irfan Majeed

et al. 2024

Drug Development and Industrial Pharmacy

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Development of Capsule containing Immediate Release Tablet and Extended Release Floating Tablet for Monitoring Release of Atenolol

Cited by 3 publications

References 16 publications

Formulation and Evaluation of Bioadhesive Pulsatile Drug Delivery System of an Antihypertensive Drug

Formulation and Evaluation of Bioadhesive Pulsatile Drug Delivery System of an Antihypertensive Drug

In-vitro Evaluation and Optimization of Sacubitril and Valsartan Floating Tablet using Natural Polymer

Quantitative analysis of solid dosage forms of Atenolol by Raman spectroscopy

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