Development of buccal film formulations and their mucoadhesive performance in biomimetic models

Göbel, Anja; Silva, Jéssica Bassi da; Cook, Michael T.; Breitkreutz, Jörg

doi:10.1016/j.ijpharm.2021.121233

Cited by 15 publications

(6 citation statements)

References 35 publications

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“…The linear relationship between the sample area and the measured values can be confirmed by the regression coefficient of R 2 (F max ) = 0.9996 and R 2 (W ad ) = 0.8164. An approximately linear relationship between the sample area with the adhesion work and the maximum detachment force has also been observed by Göbel et al [ 47 ] when they investigated the influence of the sample area of circular HPMC and PVA films with a diameter of 5–20 mm on adhesion to gelatin type A gels.…”

Section: Resultssupporting

confidence: 67%

“…As the swelling of the PVA progresses, however, adhesion again decreases as the previously dry and hydrophilic film decomposes over time to a gel-like structure that adheres more poorly to the agar/mucin gel. Göbel et al [ 47 ] investigated the influence of the contact time of PVA films on gelatin type A gels in vitro. They could not observe a clear trend in the observed time from 3–120 s of contact time.…”

Section: Resultsmentioning

confidence: 99%

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Characterization of an In Vitro/Ex Vivo Mucoadhesiveness Measurement Method of PVA Films

2022

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Transmucosal drug delivery systems can be an attractive alternative to conventional oral dosage forms such as tablets. There are numerous in vitro methods to estimate the behavior of mucoadhesive dosage forms in vivo. In this work, a tensile test system was used to measure the mucoadhesion of polyvinyl alcohol films. An in vitro screening of potential influencing variables was performed on biomimetic agar/mucin gels. Among the test device-specific factors, contact time and withdrawal speed were identified as influencing parameters. In addition, influencing factors such as the sample area, which showed a linear relationship in relation to the resulting work, and the liquid addition, which led to an abrupt decrease in adhesion, could be identified. The influence of tissue preparation was investigated in ex vivo experiments on porcine small intestinal tissue. It was found that lower values of Fmax and Wad were obtained on processed and fresh tissue than on processed and thawed tissue. Film adhesion on fresh, unprocessed tissue was lowest in most of the animals tested. Comparison of ex vivo measurements on porcine small intestinal tissue with in vitro measurements on agar/mucin gels illustrates the inter- and intra-individual variability of biological tissue.

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Section: Resultssupporting

confidence: 67%

Section: Resultsmentioning

confidence: 99%

Characterization of an In Vitro/Ex Vivo Mucoadhesiveness Measurement Method of PVA Films

2022

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“…[20] The bond strength increases with a certain level of hydration until a threshold is reached, beyond which excessive hydration leads to a sudden decline in adhesive quality due to unraveling at the interface between the polymer and mucosal tissue. [21] Mucoadhesion is usually affected by the level of H-bonding especially with moieties having carboxylic, hydroxylic or amino groups. This is evident from the varying level of mucoadhesive characteristics shown by different polymers in formulations F1, F6 and F9 (Table 4).…”

Section: Discussionmentioning

confidence: 99%

Polysaccharide Based Controlled Release Mucoadhesive Drug Delivery System for Pain Management

Namdev,

Pillai,

Pillai

et al. 2024

Int. J. Pharm. Sci. Drug Res.

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Mucoadhesion is one of the most extensively studied methods for the administration of medication for faster onset of action with enhanced bioavailability. Present investigation was concerned with the development and characterization of controlled release muco-adhesive drug delivery system for the drug Tramadol Hydrochloride (TRD) to extend the duration of analgesia for patients suffering from acute to chronic pain. Formulations were made using the solvent casting technique, incorporating natural polymers like Guar Gum, Xanthum Gum and Chitosan in conjunction with HPMC (hydroxy propyl methyl cellulose) to modify the drug release. The compatibility of film components were validated by Fourier Transform Infra- Red (FTIR) spectroscopy and subjected to physico-chemical evaluation parameters and ex-vivo drug diffusion study. Optimized formulation was tested for analgesic efficacy in vivo to determine extent of their suitability in therapeutic use. All the prepared formulations exhibited superior pharmaceutical qualities with respect to drug content, folding endurance, swelling index and mucoadhesion time. In ex-vivo drug diffusion study, all the films displayed a controlled release lasting longer than eight hours. Formulations containing Chitosan in combination with HPMC (F6) showed better controlled drug release over other combinations. The formulation F6 bring out remarkable in vivo analgesic efficacy with 58.10 % analgesia in contrast to the standard (61.16%). It was deduced that Tramadol hydrochloride mucoadhesive films were found to be an effective treatment for moderate to severe pain with a quick onset and a lengthy half-life.

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“…The commercially available synthetic polymer PAA and its derivatives are characterized by high mucoadhesive properties [ 100 ]. Various polymers, such as polycarbophil, several types of carbomer homopolymers and copolymers, have been confirmed as successful mucoadhesive matrices for the development of oral patches.…”

Section: Bioadhesive Polymersmentioning

confidence: 99%

Patches as Polymeric Systems for Improved Delivery of Topical Corticosteroids: Advances and Future Perspectives

Dubashynskaya

Skorik

2022

IJMS

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Mucoadhesive polymer patches are a promising alternative for prolonged and controlled delivery of topical corticosteroids (CS) to improve their biopharmaceutical properties (mainly increasing local bioavailability and reducing systemic toxicity). The main biopharmaceutical advantages of patches compared to traditional oral dosage forms are their excellent bioadhesive properties and their increased drug residence time, modified and unidirectional drug release, improved local bioavailability and safety profile, additional pain receptor protection, and patient friendliness. This review describes the main approaches that can be used for the pharmaceutical R&D of oromucosal patches with improved physicochemical, mechanical, and pharmacological properties. The review mainly focuses on ways to increase the bioadhesion of oromucosal patches and to modify drug release, as well as ways to improve local bioavailability and safety by developing unidirectional -release poly-layer patches. Various techniques for obtaining patches and their influence on the structure and properties of the resulting dosage forms are also presented.

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Development of buccal film formulations and their mucoadhesive performance in biomimetic models

Cited by 15 publications

References 35 publications

Characterization of an In Vitro/Ex Vivo Mucoadhesiveness Measurement Method of PVA Films

Characterization of an In Vitro/Ex Vivo Mucoadhesiveness Measurement Method of PVA Films

Polysaccharide Based Controlled Release Mucoadhesive Drug Delivery System for Pain Management

Patches as Polymeric Systems for Improved Delivery of Topical Corticosteroids: Advances and Future Perspectives

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