Development of bone substitute materials: from ‘biocompatible’ to ‘instructive’

Bongio, Matilde; Beucken, Jeroen J.J.P. van den; Leeuwenburgh, Sander C. G.; Jansen, John A.

doi:10.1039/c0jm00795a

Cited by 122 publications

(94 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This critical situation has led researchers in the field of regenerative medicine to focus on the development of synthetic biomaterials for bone regeneration, which provide temporary support to missing or damaged tissue while inducing and directing the regeneration of new healthy bone tissue [1].…”

Section: Introductionmentioning

confidence: 99%

Subcutaneous tissue response and osteogenic performance of calcium phosphate nanoparticle-enriched hydrogels in the tibial medullary cavity of guinea pigs

et al. 2013

Self Cite

View full text Add to dashboard Cite

Subcutaneous tissue response and osteogenic performance of calcium phosphate nanoparticle-enriched hydrogels in the tibial medullary cavity of guinea pigs, Acta Biomaterialia (2012), doi: http://dx.doi.org/10. 1016/j.actbio.2012.10.026 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Introductionmentioning

confidence: 99%

Subcutaneous tissue response and osteogenic performance of calcium phosphate nanoparticle-enriched hydrogels in the tibial medullary cavity of guinea pigs

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this regard, the use of biodegradable polymers, such as CS, associated to more-soluble forms of CP as bone substitutes allows the composite to initially support the mechanical stress and be re-absorbed over the time, opening space for new bone deposition (Penk et al, 2013). On the other hand, extremely high porosity and fast degradation may result in the loss of the surface that is needed for facilitation of bone formation (Bongio et al, 2010;Penk et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Morphological and mechanical characterization of chitosan-calcium phosphate composites for potential application as bone-graft substitutes

et al. 2015

View full text Add to dashboard Cite

Introduction: Bone diseases, aging and traumas can cause bone loss and lead to bone defects. Treatment of bone defects is challenging, requiring chirurgical procedures. Bone grafts are widely used for bone replacement, but they are limited and expensive. Due to bone graft limitations, natural, semi-synthetic, synthetic and composite materials have been studied as potential bone-graft substitutes. Desirable characteristics of bone-graft substitutes are high osteoinductive and angiogenic potentials, biological safety, biodegradability, bone-like mechanical properties, and reasonable cost. Herein, we prepared and characterized potential bone-graft substitutes composed of calcium phosphate (CP) -a component of natural bone, and chitosan (CS) -a biocompatible biopolymer. Methods: CP-CS composites were synthetized, molded, dried and characterized. The effect of drying temperatures (38 and 60 °C) on the morphology, porosity and chemical composition of the composites was evaluated. As well, the effects of drying temperature and period of drying (3, 24, 48 and 72 hours) on the mechanical properties -compressive strength, modulus of elasticity and relative deformation-of the demolded samples were investigated. Results: Scanning electron microscopy and gas adsorption-desorption analyses of the CS-CP composites showed interconnected pores, indicating that the drying temperature played an important role on pores size and distribution. In addition, drying temperature have altered the color (brownish at 60 °C due to Maillard reaction) and the chemical composition of the samples, confirmed by FTIR. Conclusion: Particularly, prolonged period of drying have improved mechanical properties of the CS-CP composites dried at 38 °C, which can be designed according to the mechanical needs of the replaceable bone.

show abstract

“…The majority of the marketable products listed in Table 3 belong to the first and the second generations of bone substitute biomaterials. The progress of bioceramics keeps going and in current century scientists search for the third generation of bioceramics [759] that will be able to "instruct" the physiological environment toward desired biological responses (i.e., bioceramics will be able to regenerate bone tissues by stimulating specific responses at the molecular level) [41,43,56]. One should note that these three generations should not be interpreted as chronologically but the conceptually, since each generation represents an evolution on the requirements and properties of the biomaterials involved.…”

Section: Discussionmentioning

confidence: 99%

“…After that, a more advanced definition has been introduced in September 2009: "A biomaterial is a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure, in human or veterinary medicine" [40]. These alterations in the definitions reflect a shift in conceptual ideas on biomaterials and the expectations of their biological performance, which both have changed in time [41].The biomaterials discipline is founded on http://ccaasmag.org/BIO the knowledge of the synergistic interface of material science, biology, chemistry, medicine and mechanical science and requires the input of comprehension from all these areas so that implanted biomaterials perform adequately in a living body and interrupt normal body functions as little as possible [42]. Among all of these areas, the knowledge in chemistry, material science and engineering is essential as biomaterials mainly deal with material synthesis and processing.…”

Section: General Knowledge On Biomaterials and Bioceramicsmentioning

confidence: 99%

Untitled

2011

BIO

View full text Add to dashboard Cite

In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

show abstract

Development of bone substitute materials: from ‘biocompatible’ to ‘instructive’

Cited by 122 publications

References 137 publications

Subcutaneous tissue response and osteogenic performance of calcium phosphate nanoparticle-enriched hydrogels in the tibial medullary cavity of guinea pigs

Subcutaneous tissue response and osteogenic performance of calcium phosphate nanoparticle-enriched hydrogels in the tibial medullary cavity of guinea pigs

Morphological and mechanical characterization of chitosan-calcium phosphate composites for potential application as bone-graft substitutes

Untitled

Contact Info

Product

Resources

About