Development of biphasic transdermal nitroglycerin delivery systems

Hadgraft, Jonathan; Wolff, Michael F.; Bonn, R.; Cordes, Günter

doi:10.1016/0378-5173(90)90268-9

Cited by 11 publications

(1 citation statement)

References 4 publications

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“…In addition, since the active ingredient moves with the blood stream directly into the targeted organ, the effective dose can be lower than that in the traditional drug types 3–5. Several forms of TTSs have been developed in recent years,6–8 which may be divided into two major groups: In the first case, the optimal degree of release of the active ingredient is provided by the plaster base and the plaster structure together and, in the second case, by a special microporous or nonporous membrane. In our previous work,2 the objective was to select silicon rubber base materials that will allow the development of a new TTS with optimal characteristics.…”

Section: Resultsmentioning

confidence: 99%

Development of a new silicone‐base transdermal therapeutic system. II. Study of trifunctional ingredients

Wagner

2001

J of Applied Polymer Sci

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ABSTRACT:The effect of two trifunctional silicon compounds was investigated on the polarity behavior of silicone elastomers by investigating the swelling properties in solvents of various polarity. The properties of the silicone elastomer were also influenced by methyltrimethoxysilane (MTS) and N-[(aminoethyl)aminopropyl]trimethoxysilane (GF-91) if they were used together with the networking agent. The cooperative effect of the polar liquid ingredients [glycerol, ethylene glycol, propylene glycol, poly(ethylene glycol) 400] and GF-91 as well as the dissolution of the liquid ingredients from the silicone elastomer were studied.

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Section: Resultsmentioning

confidence: 99%