Development of biodegradable polyesters with various microstructures for highly controlled release of epirubicin and cyclophosphamide

Żółtowska, Karolina; Piotrowska, Urszula; Olędzka, Ewa; Luchowska, U.; Sobczak, Marcin; Bocho-Janiszewska, A.

doi:10.1016/j.ejps.2016.10.014

Cited by 14 publications

(5 citation statements)

References 31 publications

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“…Homo-, co-, and terpolymers of L-LA, rac -LA, CL, and Gly are widely employed in medicine, e.g., as drug carriers [ 3 , 6 , 39 ]. The advantage of DDSs over traditional drug forms is from controlled and sustained drug release in the body, which is influenced, among other things, by the microstructure of the chain [ 40 ] and the composition of the polymer carrier [ 41 ]. Polyesters are distinguished mostly by their tunable microstructure and chemistry.…”

Section: Resultsmentioning

confidence: 99%

A Comprehensive Investigation of the Structural, Thermal, and Biological Properties of Fully Randomized Biomedical Polyesters Synthesized with a Nontoxic Bismuth(III) Catalyst

et al. 2022

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Aliphatic polyesters are the most common type of biodegradable synthetic polymer used in many pharmaceutical applications nowadays. This report describes the ring-opening polymerization (ROP) of l-lactide (L-LA), ε-caprolactone (CL) and glycolide (Gly) in the presence of a simple, inexpensive and convenient PEG200-BiOct3 catalytic system. The chemical structures of the obtained copolymers were characterized by 1H- or 13C-NMR. GPC was used to estimate the average molecular weight of the resulting polyesters, whereas TGA and DSC were employed to determine the thermal properties of polymeric products. The effects of temperature, reaction time, and catalyst content on the polymerization process were investigated. Importantly, the obtained polyesters were not cyto- or genotoxic, which is significant in terms of the potential for medical applications (e.g., for drug delivery systems). As a result of transesterification, the copolymers obtained had a random distribution of comonomer units along the polymer chain. The thermal analysis indicated an amorphous nature of poly(l-lactide-co-ε-caprolactone) (PLACL) and a low degree of crystallinity of poly(ε-caprolactone-co-glycolide) (PCLGA, Xc = 15.1%), in accordance with the microstructures with random distributions and short sequences of comonomer units (l = 1.02–2.82). Significant differences in reactivity were observed among comonomers, confirming preferential ring opening of L-LA during the copolymerization process.

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Section: Resultsmentioning

confidence: 99%

A Comprehensive Investigation of the Structural, Thermal, and Biological Properties of Fully Randomized Biomedical Polyesters Synthesized with a Nontoxic Bismuth(III) Catalyst

et al. 2022

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“…The kinetic release of CIP or TEMP from the selected synthesized matrices (PCL-1-CIT and PCL-1-TEMP, obtained from the PCL-1 matrix; PCL-2-CIT and PCL-2-TEMP, obtained from the PCL-2 matrix) was determined at pH 7.4 and 37 °C over 28 days (Figure 3). The ordinate of the plot was calculated based on the cumulative amount of peptide released [28].…”

Section: Resultsmentioning

confidence: 99%

A Novel Delivery System for the Controlled Release~of Antimicrobial Peptides: Citropin 1.1 and Temporin A

et al. 2018

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Antimicrobial peptides (AMPs) are prospective therapeutic options for treating multiple-strain infections. However, clinical and commercial development of AMPs has some limitations due to their limited stability, low bioavailability, and potential hemotoxicity. The purpose of this study was to develop new polymeric carriers as highly controlled release devices for amphibian peptides citropin 1.1 (CIT) and temporin A (TEMP). The release rate of the active pharmaceutical ingredients (APIs) was strongly dependent on the API characteristics and the matrix microstructure. In the current work, we investigated the effect of the polymer microstructure on in vitro release kinetics of AMPs. Non-contact laser profilometry, scanning electron microscopy (SEM), and differential scanning calorimetry (DSC) were used to determine the structural changes during matrix degradation. Moreover, geno- and cytotoxicity of the synthesized new carriers were evaluated. The in vitro release study of AMPs from the obtained non-toxic matrices shows that peptides were released with near-zero-order kinetics. The peptide “burst release” effect was not observed. New devices have reached the therapeutic concentration of AMPs within 24 h and maintained it for 28 days. Hence, our results suggest that these polymeric devices could be potentially used as therapeutic options for the treatment of local infections.

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“…These drugs can damage the bone marrow and gastrointestinal mucosa and, in high doses, can be nephrotoxic and neurotoxic. 100 Although anti-cancer agents and RT have demonstrated many benefits in patients, these therapies in RMSs have many disadvantages, including the induction of multidrug resistance protein activity and the appearance of toxic side effects. It is also noteworthy that almost all anti-cancer agents affect not only cancer but also healthy cells.…”

Section: Limitations In Current Rms Treatmentmentioning

confidence: 99%

The natural origins of cytostatic compounds used in rhabdomyosarcoma therapy

Lewandowski¹,

Szewczyk²,

Radzka³

et al. 2023

Adv Clin Exp Med

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Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and represents a highgrade neoplasm of skeletal myoblast-like cells. About 40% of all registered soft tissue tumors are RMSs. This paper describes our current understanding of the RMS subtypes (alveolar (ARMS), embryonic (ERMS), pleomorphic (PRMS), and spindle cell/sclerosing (s/scRMS)), diagnostic methods, molecular bases, and characteristics. We also present the currently used treatment methods and the potential use of natural substances in the treatment of this type of cancer. Natural cytotoxic substances are compounds that have been the subject of numerous studies and discussions in recent years. Since anti-cancer therapies are often limited by a low therapeutic index and cancer resistance to pharmacotherapy, it is very important to search for new, effective compounds. Additionally, compounds of a natural origin are usually readily available and have a reduced cytotoxicity. Thus, the undiscovered potential of natural anti-cancer compounds makes this field of research a very important area. The introduction of model species into research examining the use of natural cytostatic therapies for RMS will allow for further assessment of the effects of these compounds on cancerous and healthy tissues.

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Development of biodegradable polyesters with various microstructures for highly controlled release of epirubicin and cyclophosphamide

Cited by 14 publications

References 31 publications

A Comprehensive Investigation of the Structural, Thermal, and Biological Properties of Fully Randomized Biomedical Polyesters Synthesized with a Nontoxic Bismuth(III) Catalyst

A Comprehensive Investigation of the Structural, Thermal, and Biological Properties of Fully Randomized Biomedical Polyesters Synthesized with a Nontoxic Bismuth(III) Catalyst

A Novel Delivery System for the Controlled Release~of Antimicrobial Peptides: Citropin 1.1 and Temporin A

The natural origins of cytostatic compounds used in rhabdomyosarcoma therapy

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