Development of Biocomposite Polymeric Systems Loaded with Antibacterial Nanoparticles for the Coating of Polypropylene Biomaterials

Fernández-Gutiérrez, Mar; Pérez-Köhler, Bárbara; Benito-Martínez, Selma; García-Moreno, Francisca; Pascual, Gemma; García‐Fernández, Luis; Aguilar, María Rosa; Vázquez‐Lasa, Blanca; Bellón, Juan M.

doi:10.3390/polym12081829

Cited by 13 publications

(9 citation statements)

References 43 publications

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“…The authors showed the cellular internalization with intracellular cytoplasmic localization and preserved fluorescence and necrosis affinity for Hyp-NPs, suggesting their potential applications in tumor imaging and therapy [86]. Fernández-Gutiérrez and coworkers reported the fabrication of a biocomposite polymeric system for the antibacterial coating of polypropylene mesh materials for hernia repair [87]. Figure 4(a)-(d) shows the microscopic and scanning electron microscopic (SEM) images of the meshes with different coatings.…”

Section: Nanomedicinementioning

confidence: 99%

“…The antibacterial coating was performed by a film of chitosan containing poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles loaded with antibiotic (rifampicin) or an antiseptic (chlorhexidine). Both biocomposite coatings exhibited antibacterial activity and cell compatibility, offering a potential strategy to protect meshes from bacterial adhesion following implantation [87].…”

Section: Nanomedicinementioning

confidence: 99%

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Novel Acumens into Biodegradation: Impact of Nanomaterials and Their Contribution

Manatunga¹,

Dassanayake²,

Liyanage³

2022

Biodegradation Technology of Organic and Inorganic Pollutants

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Biodegradation is the most viable alternative for numerous health and environmental issues associated with non-biodegradable materials. In recent years, there has been considerable interest in biodegradable nanomaterials due to their relative abundance, environmental benignity, low cost, easy use, and tunable properties. This chapter covers an overview of biodegradation, factors and challenges associated with biodegradation processes, involvement of nanotechnology and nanomaterials in biodegradation, and biodegradable nanomaterials. Furthermore, current chapter extensively is discusses the most recent applications of biodegradable nanomaterials that have recently been explored in the areas of food packaging, energy, environmental remediation, and nanomedicine. Overall, this chapter provides a synopsis of how the involvement of nanotechnology would benefit the process of biodegradation.

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Section: Nanomedicinementioning

confidence: 99%

Section: Nanomedicinementioning

confidence: 99%

Novel Acumens into Biodegradation: Impact of Nanomaterials and Their Contribution

Manatunga¹,

Dassanayake²,

Liyanage³

2022

Biodegradation Technology of Organic and Inorganic Pollutants

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show abstract

“…Chitosan has been widely employed in tissue engineering and biomedical applications due to its biocompatibility, biodegradability, and antimicrobial activity [147][148][149][150]. Normally, chitosan is crosslinked using genipin or glutaraldehyde by a chemical crosslinking mechanism [151].…”

Section: Chitosan Based Bioinksmentioning

confidence: 99%

Emerging Biofabrication Techniques: A Review on Natural Polymers for Biomedical Applications

2021

Self Cite

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Natural polymers have been widely used for biomedical applications in recent decades. They offer the advantages of resembling the extracellular matrix of native tissues and retaining biochemical cues and properties necessary to enhance their biocompatibility, so they usually improve the cellular attachment and behavior and avoid immunological reactions. Moreover, they offer a rapid degradability through natural enzymatic or chemical processes. However, natural polymers present poor mechanical strength, which frequently makes the manipulation processes difficult. Recent advances in biofabrication, 3D printing, microfluidics, and cell-electrospinning allow the manufacturing of complex natural polymer matrixes with biophysical and structural properties similar to those of the extracellular matrix. In addition, these techniques offer the possibility of incorporating different cell lines into the fabrication process, a revolutionary strategy broadly explored in recent years to produce cell-laden scaffolds that can better mimic the properties of functional tissues. In this review, the use of 3D printing, microfluidics, and electrospinning approaches has been extensively investigated for the biofabrication of naturally derived polymer scaffolds with encapsulated cells intended for biomedical applications (e.g., cell therapies, bone and dental grafts, cardiovascular or musculoskeletal tissue regeneration, and wound healing).

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“…Therefore, it is indispensable to study how to prolong and control the release time of drugs. Fernandez-Gutierrez et al 55 coated PP mesh with a film of CS containing randomly dispersed PLGA nanoparticles loaded with rifampicin. Experiments demonstrated that the coatings with rifampicin were gradually released over no less than 11 days and effectively precluded bacterial colonization of mesh.…”

Section: Strategies For Reducing Postoperative Complicationsmentioning

confidence: 99%

Latest Trends on the Attenuation of Systemic Foreign Body Response and Infectious Complications of Synthetic Hernia Meshes

Fang

Wang

et al. 2021

ACS Appl. Bio Mater.

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Throughout the past few years, hernia incidence has remained at a high level worldwide, with more than 20 million people requiring hernia surgery each year. Synthetic hernia meshes play an important role, providing a microenvironment that attracts and harbors host cells and acting as a permanent roadmap for intact abdominal wall reconstruction. Nevertheless, it is still inevitable to cause not-so-trivial complications, especially chronic pain and adhesion. In long-term studies, it was found that the complications are mainly caused by excessive fibrosis from the foreign body reaction (FBR) and infection resulting from bacterial colonization. For a thorough understanding of their complex mechanism and providing a richer background for mesh development, herein, we discuss different clinical mesh products and explore the interactions between their structure and complications. We further explored progress in reducing mesh complications to provide varied strategies that are informative and instructive for mesh modification in different research directions. We hope that this work will spur hernia mesh designers to step up their efforts to develop more practical and accessible meshes by improving the physical structure and chemical properties of meshes to combat the increasing risk of adhesions, infections, and inflammatory reactions. We conclude that further work is needed to solve this pressing problem, especially in the analysis and functionalization of mesh materials, provided of course that the initial performance of the mesh is guaranteed.

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Development of Biocomposite Polymeric Systems Loaded with Antibacterial Nanoparticles for the Coating of Polypropylene Biomaterials

Cited by 13 publications

References 43 publications

Novel Acumens into Biodegradation: Impact of Nanomaterials and Their Contribution

Novel Acumens into Biodegradation: Impact of Nanomaterials and Their Contribution

Emerging Biofabrication Techniques: A Review on Natural Polymers for Biomedical Applications

Latest Trends on the Attenuation of Systemic Foreign Body Response and Infectious Complications of Synthetic Hernia Meshes

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