Development of Biocompatible Resins for 3D Printing of Direct Aligners

Nakano, Haruhisa; Kato, Riyu; Kakami, Chifumi; Okamoto, H.; Mamada, Katsuyoshi; Maki, Koutaro

doi:10.2494/photopolymer.32.209

Cited by 24 publications

(25 citation statements)

References 14 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the 14 studies included in the qualitative analysis, one was a clinical study (RCT), one was an in vivo model, and the remaining 12 were in vitro studies. To assess cytotoxicity in vitro studies, those using cell lines, cell cultures, or a chemical analysis of extracts were included [ 10 , 11 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. This evaluation was carried out through several assays, namely, the MTT assay, XTT assay, morphology, mass spectroscopy, gas chromatography, among others.…”

Section: Resultsmentioning

confidence: 99%

The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

Three-dimensional (3D) resin medical-dental devices have been increasingly used in recent years after the emergence of digital technologies. In Orthodontics, therapies with aligners have gained popularity, mainly due to the aggressive promotion policies developed by the industry. However, their systemic effects are largely unknown, with few studies evaluating the systemic toxicity of these materials. The release of bisphenol A and other residual monomers have cytotoxic, genotoxic, and estrogenic effects. This systematic review aims to analyze the release of toxic substances from 3D resins used in Orthodontics and their toxic systemic effects systematically. The PICO question asked was, “Does the use of 3D resins in orthodontic devices induce cytotoxic effects or changes in estrogen levels?”. The search was carried out in several databases and according to PRISMA guidelines. In vitro, in vivo, and clinical studies were included. The in vitro studies’ risk of bias was assessed using the guidelines for the reporting of pre-clinical studies on dental materials by Faggion Jr. For the in vivo studies, the SYRCLE risk of bias tool was used, and for the clinical studies, the Cochrane tool. A total of 400 articles retrieved from the databases were initially scrutinized. Fourteen articles were included for qualitative analysis. The risk of bias was considered medium to high. Cytotoxic effects or estrogen levels cannot be confirmed based on the limited preliminary evidence given by in vitro studies. Evidence of the release of bisphenol A and other monomers from 3D resin devices, either in vitro or clinical studies, remains ambiguous. The few robust results in the current literature demonstrate the absolute need for further studies, especially given the possible implications for the young patient’s fertility, which constitutes one of the largest groups of patients using these orthodontic devices.

show abstract

Section: Resultsmentioning

confidence: 99%

The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…However, this clear resin is stated as a biocompatible, dimensionally stable, flexible, and strong material for the direct 3D printing of what is known in orthodontics as a “first aligner”—a retainer that is used after an orthodontist removes a patient’s brackets to hold teeth in place before the treatment is completed with a series of conventionally made thermoformed aligners [ 37 ]. Nowadays, there is no marketed and approved photopolymerizable resin suited for the direct printing of dental clear aligners but an increasing interest in the field of orthodontics is taking place, especially for the development of certified biocompatible resins [ 38 ]. Despite the lack of existing biocompatible resins for 3D direct clear aligners, some experimental trials have been carried out on voluntary patients with modified resins and post-printing protocols, but clinical outcomes need to be confirmed prior to scientific publishing ( Figure 3 ).…”

Section: Main Textmentioning

confidence: 99%

Direct 3D Printing of Clear Orthodontic Aligners: Current State and Future Possibilities

et al. 2021

View full text Add to dashboard Cite

The recent introduction of three-dimensional (3D) printing is revolutionizing dentistry and is even being applied to orthodontic treatment of malocclusion. Clear, personalized, removable aligners are a suitable alternative to conventional orthodontic appliances, offering a more comfortable and efficient solution for patients. Including improved oral hygiene and aesthetics during treatment. Contemporarily, clear aligners are produced by a thermoforming process using various types of thermoplastic materials. The thermoforming procedure alters the properties of the material, and the intraoral environment further modifies the properties of a clear aligner, affecting overall performance of the material. Direct 3D printing offers the creation of highly precise clear aligners with soft edges, digitally designed and identically reproduced for an entire set of treatment aligners; offering a better fit, higher efficacy, and reproducibility. Despite the known benefits of 3D printing and the popularity of its dental applications, very limited technical and clinical data are available in the literature about directly printed clear aligners. The present article discusses the advantages of 3D printed aligners in comparison to thermoformed ones, describes the current state of the art, including a discussion of the possible road blocks that exist such as a current lack of approved and marketed materials and limited existence of aligner specific software. The present review suggests the suitability of 3D direct printed aligners is superior to that of thermoformed manufactured aligners because of the prior’s increased accuracy, load resistance, and lower deformation. It is an overall more stable way to produce an aligner where submillimeter movements can make a difference in treatment outcome. Direct 3D printing represents a complex method to control the thickness of the aligner and therefore has a better ability to control the force vectors that are used to produce tooth movement. There is currently no other approved material on the market that can do this. The conclusion of this article is that we encourage further in vitro and in vivo studies to test these new technologies and materials.

show abstract

“…Given these qualities, when a specially appointed sap is free on the lookout, straightforwardly 3Dprinted aligners should be tried clinically to show their biomechanical viability. Various plans ought to be presumably utilized the assembling of detachable clips contrasted with thermosettable ones because of the chance of making adaptable wideness and connections; traditional properties of adjustable clips in regard to the materials, thickness, and helper components can likewise be examined by invariable demonstrating and limited component investigation [1,16].…”

Section: Biomedical Materials For Orthodonticsmentioning

confidence: 99%

A critique on Materials for Orthodontic Aligners through sustainable Manufacturing

Kilaru¹

2021

E3S Web Conf.

View full text Add to dashboard Cite

Materials will play an important role in any manufacturing sector. Additive manufacturing is the one of the most Emerging Manufacturing technology which is adding a sustainable dimension to Human life by using bio medical dental aligners in orthodontics. The new presentation of Sustainable manufacturing is upsetting endodontist, furthermore, it is in any event, it is applied to dental treatment of poor alignment of teeth and jaws. Exact, customized, Detachable aligners are an appropriate option in contrast to ordinary orthodontic machines, offering a more agreeable furthermore, and productive answer for patients Simultaneously, Detachable Clips are created by a thermoset’s interaction utilizing different sorts of thermoset elements. The Elastomer system modifies the Characteristics of the element, and the intra oral climate moreover changes the characteristic of an unmistakable clip, influencing execution of the element. The current audit recommends the appropriateness of Additive manufactured aligners is better than that of thermoset made aligners due to earlier expanded precision, load obstruction, and lower twisting. It is a general steadier approach to produce an aligner where sub millimetre developments can have an effect in treatment result. Direct 3D printing addresses an intricate strategy to command the density of the aligner and in this manner has superior capacity to command the power angle that are utilized to create teeth development. There is presently no other endorsed material available that can make this.

show abstract

Development of Biocompatible Resins for 3D Printing of Direct Aligners

Cited by 24 publications

References 14 publications

The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review

The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review

Direct 3D Printing of Clear Orthodontic Aligners: Current State and Future Possibilities

A critique on Materials for Orthodontic Aligners through sustainable Manufacturing

Contact Info

Product

Resources

About