Development of biocompatible nanogel for sustained drug release by overcoming the blood brain barrier in zebrafish model

Sivaji, Kalaiarasi; Pitchai, Arjun; Nandhagopal, Soundarapandian; Brijitta, J.; Iniyan, Appadurai Muthamil; Vincent, Samuel Gnana Prakash; Kannan, Rajaretinam Rajesh

doi:10.1016/j.jab.2016.01.004

Cited by 32 publications

(18 citation statements)

References 42 publications

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“…The coating with PS80 permitted the crossing of NG through the BBB. The toxicity of PS80 was previously established in zebrafish and optimized in this study [ 18 ]. 5 nl of NG, NG + Rh–B, or NG + Rh–B + PS80 were injected with a Femtojet microinjector (Eppendorf).…”

Section: Methodsmentioning

confidence: 99%

Neurospecific fabrication and toxicity assessment of a PNIPAM nanogel encapsulated with trans-tephrostachin for blood-brain-barrier permeability in zebrafish model

Pitchai

Freeman²,

Kannan³

2022

Heliyon

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Section: Methodsmentioning

confidence: 99%

Neurospecific fabrication and toxicity assessment of a PNIPAM nanogel encapsulated with trans-tephrostachin for blood-brain-barrier permeability in zebrafish model

Pitchai

Freeman²,

Kannan³

2022

Heliyon

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“…They reported that the nanoparticle altered neurotransmission in the zebrafish brain as it had an effect on the acetylcholine esterase activity. In an interesting work Sivaji et al [ 198 ] aimed to deliver donepezil, a well-established drug for Alzheimer’s disease, through functionalized poly N -isopropyl acrylamide nanogels PNIPAM nanogel to the brain. They reported the gel could overcome the BBB and also showed sustained drug release using zebrafish model.…”

Section: Nanoparticles Focused For Delivering Drug To the Brainmentioning

confidence: 99%

Zebrafish: A Promising Real-Time Model System for Nanotechnology-Mediated Neurospecific Drug Delivery

Saleem

Kannan

2021

Nanoscale Res Lett

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Delivering drugs to the brain has always remained a challenge for the research community and physicians. The blood–brain barrier (BBB) acts as a major hurdle for delivering drugs to specific parts of the brain and the central nervous system. It is physiologically comprised of complex network of capillaries to protect the brain from any invasive agents or foreign particles. Therefore, there is an absolute need for understanding of the BBB for successful therapeutic interventions. Recent research indicates the strong emergence of zebrafish as a model for assessing the permeability of the BBB, which is highly conserved in its structure and function between the zebrafish and mammals. The zebrafish model system offers a plethora of advantages including easy maintenance, high fecundity and transparency of embryos and larvae. Therefore, it has the potential to be developed as a model for analysing and elucidating the permeability of BBB to novel permeation technologies with neurospecificity. Nanotechnology has now become a focus area within the industrial and research community for delivering drugs to the brain. Nanoparticles are being developed with increased efficiency and accuracy for overcoming the BBB and delivering neurospecific drugs to the brain. The zebrafish stands as an excellent model system to assess nanoparticle biocompatibility and toxicity. Hence, the zebrafish model is indispensable for the discovery or development of novel technologies for neurospecific drug delivery and potential therapies for brain diseases.

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“…Hydrogel formed with PNIAM has been studied successfully in Zebrafish model for sustained drug release and compatibility. PNIAM hydrogel is a functionalized nanogel loaded with donepezil with polysorbate-80 57 .…”

Section: Nanogelsmentioning

confidence: 99%

Nanoscience in Multiple Sclerosis

Gurav

Mhatre

2019

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Multiple Sclerosis (MS) -the most common autoimmune disease of the central nervous system -is traditionally diagnosed by methods mainly using magnetic resonance techniques to detect the lesions. Use of nanoparticles as the contrast agents can help in better diagnosis of the damaged cells. Iron nanoparticles are used in various advanced techniques like superparamagnetic iron oxide nanoparticles (SPIONs) and ultra-small SPIONs (USPIONs). The major challenge in treatment of MS is the delivery of the drug into the brain, crossing the blood brain barrier (BBB). Nanoparticles like liposomes, nanoshells, dendrimers, nanogels, micelles have potential applications in the same. Presently, no significant treatment is devoid of side effects like fever, headache and fatigue, Use of nanoscience in MS in drug delivery and treatment can help solve the prevailing inadequacies. Administered quantum dots conjugated with self-antigens act on lymph nodes and spleen. These assemblies produce regulatory T-cells which prevent degeneration of myelin sheath. New studies study modifications to produce inflammation-resistant myelin by inducing response in lymph nodes during T-cell priming. This review aims to briefly describe the application of nanotechnology in diagnosis, drug delivery and treatment of MS.

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Development of biocompatible nanogel for sustained drug release by overcoming the blood brain barrier in zebrafish model

Cited by 32 publications

References 42 publications

Neurospecific fabrication and toxicity assessment of a PNIPAM nanogel encapsulated with trans-tephrostachin for blood-brain-barrier permeability in zebrafish model

Neurospecific fabrication and toxicity assessment of a PNIPAM nanogel encapsulated with trans-tephrostachin for blood-brain-barrier permeability in zebrafish model

Zebrafish: A Promising Real-Time Model System for Nanotechnology-Mediated Neurospecific Drug Delivery

Nanoscience in Multiple Sclerosis

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