Development of Biocompatible Electrospun PHBV-PLLA Polymeric Bilayer Composite Membranes for Skin Tissue Engineering Applications
Muddasar Jamal,
Faiza Sharif,
Muhammad Shozab Mehdi
et al.
Abstract:Bilayer electrospun fibers aimed to be used for skin tissue engineering applications were fabricated for enhanced cell attachment and proliferation. Different ratios of PHBV-PLLA (70:30, 80:20, and 90:10 w/w) blends were electrospun on previously formed electrospun PHBV membranes to produce their bilayers. The fabricated electrospun membranes were characterized with FTIR, which conformed to the characteristic peaks assigned for both PHBV and PLLA. The surface morphology was evaluated using SEM analysis that sh… Show more
“…[21][22][23] Besides some studies have explored the use of PHBV composites with bronectin or collagen in wound healing and vascular tissue engineering. 24,25 Despite its remarkable properties, PHAs (especially scl's) have drawbacks like high fragility, low impact resistance, reduced elongation at break, and poor mechanical strength. In this study, we have blended PHBV with 1 wt% poly(L-lactic acid) (PLLA) and 1 wt% poly(3-caprolactone) (PCL).…”
We explore the potential of a copolymer, poly[(3-hydroxybutyrate)-co-(3-hydroxyvalerate), naturally synthesized by Halogeometricum borinquense E3, as a potential tissue engineering biomaterial.
“…[21][22][23] Besides some studies have explored the use of PHBV composites with bronectin or collagen in wound healing and vascular tissue engineering. 24,25 Despite its remarkable properties, PHAs (especially scl's) have drawbacks like high fragility, low impact resistance, reduced elongation at break, and poor mechanical strength. In this study, we have blended PHBV with 1 wt% poly(L-lactic acid) (PLLA) and 1 wt% poly(3-caprolactone) (PCL).…”
We explore the potential of a copolymer, poly[(3-hydroxybutyrate)-co-(3-hydroxyvalerate), naturally synthesized by Halogeometricum borinquense E3, as a potential tissue engineering biomaterial.
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