Development of Bilayer Floating Tablet of Amoxicillin and Aloe vera Gel Powder for Treatment of Gastric Ulcers

Ranade, Arati N.; Wankhede, Sonali S.; Ranpise, Nisharani S.; Mundada, Mayur S.

doi:10.1208/s12249-012-9882-4

Cited by 28 publications

(21 citation statements)

References 11 publications

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“…Recently, Ranade et al . () developed an innovative floating tablet with A. vera in combination with amoxicillin to contrast the H. pylori ‐induced peptic ulcer, showing that A. vera could be a source of new co‐therapeutics. In this innovative system, A. vera inner gel improves the amoxicillin adsorption through its retention in the gastric mucosa.…”

Section: Resultsmentioning

confidence: 99%

“…This anti-adhesive effect exhibited in vitro by A. vera on gastric cells together with the antimicrobial activity against H. pylori could represent an efficacious combination to counteract the bacterial infection. Recently, Ranade et al (2012) developed an innovative floating tablet with A. vera in combination with amoxicillin to contrast the H. pylori-induced peptic ulcer, showing that A. vera could be a source of new cotherapeutics. In this innovative system, A. vera inner gel improves the amoxicillin adsorption through its retention in the gastric mucosa.…”

Section: Resultsmentioning

confidence: 99%

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In vitro activity of Aloe vera inner gel against Helicobacter pylori strains

Cellini

Bartolomeo

Campli

et al. 2014

Lett Appl Microbiol

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Significance and Impact of the Study: The study demonstrates that the Aloe vera inner gel expresses antibacterial properties against both susceptible and resistant Helicobacter pylori strains. These findings may impact on the antimicrobial resistance phenomenon of H. pylori, proposing the A. vera inner gel as a novel effective natural agent for combination with antibiotics for the treatment of H. pylori gastric infection. KeywordsAloe vera, antibacterial activity, Helicobacter pylori, resistant strains, therapeutic regimens. AbstractAloe barbadensis Miller (Aloe vera) is a herbal remedy widely used for a variety of illnesses; A. vera leaf extracts have been promoted for detoxification, cure constipation, help flush out toxins and wastes from the body, promote digestion and are used in the treatment of peptic ulcer for cytoprotective action. The aim of this study was to evaluate the antibacterial activity of A. vera inner gel against both susceptible and resistant Helicobacter pylori strains isolated in Abruzzo region, Italy. The inner gel of leaves of a 5-year-old plant of A. vera was extracted, homogenized and tested from 800 to 1Á56 mg ml À1 against 14 clinical strains and one reference strain of H. pylori using the broth microdilution methodology. Furthermore, the sample of A. vera was investigated for the chemical fingerprint of anthraquinones. The inhibitory concentrations of A. vera inner gel were similar to the bactericidal ones, with values ranging from 6Á25 to 800 mg ml À1 . Fifty per cent of the detected strains, independently of their susceptibility profile, were inhibited in their growth at 100 mg ml À1 . Aloe vera inner gel expresses antibacterial properties against H. pylori and, therefore, in combination with antibiotics, could represent a novel strategy for the treatment of the infection of H. pylori, especially in cases of multiresistance.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

In vitro activity of Aloe vera inner gel against Helicobacter pylori strains

Cellini

Bartolomeo

Campli

et al. 2014

Lett Appl Microbiol

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“…The total time for which the tablet floated in the dissolution medium, including the floating lag time, was recorded as the total floating time. [2] For drug release studies, 10 mL of the sample was withdrawn at 10, 20, 30, 60,120,180, 240, 300, 360 and 420 min and was replaced with an equal volume of dissolution medium. After suitable dilution, the amount of drug released was estimated by a UV spectrophotometric method at 254 nm.…”

Section: Content Uniformitymentioning

confidence: 99%

“…[2] The present investigation is designed to deliver and retain two herbal constituents in the stomach for better action against gastric ulcers caused by H. pylori. For this purpose, two isolated herbal constituents -glycyrrhizin and Aloe vera powder-were selected.…”

Section: Introductionmentioning

confidence: 99%

Enrichment of anti-ulcer activity of monoammonium glycerrhizin and Aloe vera gel powder through a novel drug delivery system

Ranade¹,

Ramesh²,

Ranpise³

2014

Asian J Pharm

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U sual treatment for Helicobacter pylori-induced peptic ulcer includes a 14-day "triple therapy" of two antibiotics and a proton pump inhibitor. However, the current therapy has side-effects like stomach upset, non-compliance, incomplete absorption of drug and antibiotic resistance. To overcome these limitations, there is a need to suggest an alternative therapy. The best possible alternative is to deliver herbal constituents. The purpose of the present study was to optimize the efficacy of herbal constituents by applying the concept of a novel drug delivery system. The present investigation is designed to deliver and retain two herbal constituents in the stomach for better action against gastric ulcers. The objective was to develop a bilayer floating tablet of monoammonium glycerrhizin and Aloe vera gel powder through rational combination of excipients to give the lowest possible lag time with maximum drug release in 7 h. Formulation OF2 containing hydroxy propyl methyl cellulose E5, crospovidone and effervescent agents in the ratio 1:2 gave 98% drug release with desired floating properties. Pharmacodynamic studies in rats showed that the combination of monoammonium glycerrhizin and Aloe vera gave 99% ulcer inhibition in comparison with 51% ulcer inhibition in the group administered with monoammonium glycerrhizin alone. X-ray studies in rabbits proved the gastroretention of the tablet for more than 6 h. This suggests relevance of NDDS in delivery of herbal constituents in the treatment of gastric ulcer.

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“…Crosscarmellose sodium and sodium starch glycolate are mostly preferred superdisintegrants because of high water uptake and rapid action . Gum acacia as a sustained release carrier in a matrix formulation shows improved drug‐retarding capability because of its gelling property . Pectin, a naturally occurring polymer, matrices can be applied for the release of both hydrophilic and hydrophobic drugs .…”

Section: Introductionmentioning

confidence: 99%

Design and Evaluation of Bilayer Matrix Tablet of Metoprolol Tartrate and Lisinopril Maleate

et al. 2015

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The objective of study was to design bilayer matrix tablet of metoprolol tartrate and lisinopril maleate. The direct compression method was used for preparation of both layers. Precompression and postcompression parameters were evaluated. USP Type II dissolution apparatus was used for the in vitro drug release study using 0.1 N HCl for immediate release of lisinopril maleate layer for 2 h and phosphate buffer at pH 6.8 for 10 h for metoprolol tartrate sustained layer. In vitro data were fitted into various kinetic models. Precompression parameters showed good flow properties of powder blend. Postcompression parameters were within compendia range. L7 (2% SSG and 3% CC-Na) was selected for formulation of immediate release layer that showed 91.6% drug release after 10 min, and for sustained release formulation, M4 (9% pectin, 9% acacia, and 20% Eudragit L100) showed 92.5% drug release for 10 h. Most formulations of sustained layer followed Higuchi drug release kinetics. Bilayer matrix tablet of metoprolol tartrate and lisinopril maleate can be formulated for the treatment of postmyocardial infarction. C 2015 Wiley Periodicals, Inc. Adv Polym Technol 201 , , 21582; View this article online at wileyonlinelibrary.com.

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Development of Bilayer Floating Tablet of Amoxicillin and Aloe vera Gel Powder for Treatment of Gastric Ulcers

Cited by 28 publications

References 11 publications

In vitro activity of Aloe vera inner gel against Helicobacter pylori strains

In vitro activity of Aloe vera inner gel against Helicobacter pylori strains

Enrichment of anti-ulcer activity of monoammonium glycerrhizin and Aloe vera gel powder through a novel drug delivery system

Design and Evaluation of Bilayer Matrix Tablet of Metoprolol Tartrate and Lisinopril Maleate

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