Development of bacterial cellulose based slow-release active films by incorporation of Scrophularia striata Boiss. extract

Sukhtezari, Shokoofeh; Almasi, Hadi; Pirsa, Sajad; Zandi, Mohsen; Pirouzifard, Mirkhalil

doi:10.1016/j.carbpol.2016.09.058

Cited by 77 publications

(31 citation statements)

References 41 publications

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“…Three categories of nanocellulose materials have been described as drug carriers: planar hydrogels (fleeces, films, membranes, coatings) [410][411][412][413], CNFs [414,415] as well as CNCs [416][417][418][419], with the two latter preferentially formulated as nano-and microparticles, gels, or suspensions [9]. For the entrapment of drugs these materials were used in the wet native [37,420,421], dried (freeze-dried, critical point dried) [422] or semi-dried [413,423] form, as well as air-dried materials with a shape memory effect [29,424].…”

Section: Figure 16mentioning

confidence: 99%

“…Still challenging is the controlled release of highly lipophilic drugs due to their incompatibility with the hydrophilic character of the nanocelluloses [412,426,432]. Cetyl trimethylammonium bromide-coated CNCs bound significant quantities of the hydrophobic drugs docetaxel, paclitaxel, and etoposide followed by about 20-26% release in the first hours and a longer release period of 2-4 days [432].…”

Section: Figure 16mentioning

confidence: 99%

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Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

et al. 2018

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Nanocelluloses are natural materials with at least one dimension in the nano-scale. They combine important cellulose properties with the features of nanomaterials and open new horizons for materials science and its applications. The field of nanocellulose materials is subdivided into three domains: biotechnologically produced bacterial nanocellulose hydrogels, mechanically delaminated cellulose nanofibers, and hydrolytically extracted cellulose nanocrystals. This review article describes today's state regarding the production, structural details, physicochemical properties, and innovative applications of these nanocelluloses. Promising technical applications including gels/foams, thickeners/stabilizers as well as reinforcing agents have been proposed and research from last five years indicates new potential for groundbreaking innovations in the areas of cosmetic products, wound dressings, drug carriers, medical implants, tissue engineering, food and composites. The current state of worldwide commercialization and the challenge of reducing nanocellulose production costs are also discussed.

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Section: Figure 16mentioning

confidence: 99%

Section: Figure 16mentioning

confidence: 99%

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

et al. 2018

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“…For the development of dermal patches, the porosity of BC is easily exploited to load drugs with different features, ranging from antibacterial activity to anticancer properties . Additionally, BC can be further optimized by chemical modifications with other (bio)polymers or by producing BC‐based materials, to better control its cargo release, burst, or sustained release, and even responsive releases to pH, temperature, or electromagnetism . For the development of oral formulations, BC has been used in combination with other biopolymers for a controlled release of the drug within, e.g., for the oral delivery of insulin, and hydrophobic and hydrophilic drugs alike …”

Section: Applicationsmentioning

confidence: 99%

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Carvalho

Guedes

Sousa

et al. 2019

Biotechnology Journal

120

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Bacterial cellulose (BC) is a nanocellulose form produced by some nonpathogenic bacteria. BC presents unique physical, chemical, and biological properties that make it a very versatile material and has found application in several fields, namely in food industry, cosmetics, and biomedicine. This review overviews the latest state‐of‐the‐art usage of BC on three important areas of the biomedical field, namely delivery systems, wound dressing and healing materials, and tissue engineering for regenerative medicine. BC will be reviewed as a promising biopolymer for the design and development of innovative materials for the mentioned applications. Overall, BC is shown to be an effective and versatile carrier for delivery systems, a safe and multicustomizable patch or graft for wound dressing and healing applications, and a material that can be further tuned to better adjust for each tissue engineering application, by using different methods.

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“…Natural antibacterial plant extracts like silymarin isolated from milk thistle have been used to make nanoparticles with zein, and immersing BC hydrogels in the silymarin-zein nanoparticle suspensions has been used to produce films which inhibited growth E. coli, S. aureus, and P. aeruginosa though more so for the air dried films as compared to the lyophilized films [140]. Other extracts, like scrophulariastriata boiss extract as well as mulberry leaf acid hydrolysate have been added to the growth media during production of BC films with the latter showing reduction in the growth of both E. coli and S. aureus which they attributed to antibacterial flavonoids of the mulberry leaf extract that were embedded in the bacterial cellulose for sustained release [141,142].…”

Section: Biomedical Application Area Key Features Refmentioning

confidence: 99%

Engineering Bacterial Cellulose for Diverse Biomedical Applications

Sandhu¹,

Arpa²,

Chen³

et al. 2019

rpm

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Increasing interest in bacterial cellulose due to the huge potential which exists for the development of this new biomaterial for medical applications has been met with recent growth in research in engineering this unique microbial manufactured material. The mechanical properties, porosity, and biocompatibility of bacterial cellulose derived biomaterials are particularly attractive for use in wound healing, tissue engineering, and drug delivery applications. Advances in synthetic biology and soft materials engineering are pushing the value of this biomaterial to new levels. This review provides and in-depth discussion of these most recent approaches in processing as well as physical, chemical, and genetic modification of bacterial cellulose toward further improvement and expansion of its functionality. In addition, we provide specific attention to the marketed applications of the resulting engineered materials for medical research and conclude with prospective areas of consideration for expanding the clinical utility of this biomaterial to new directions.

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Development of bacterial cellulose based slow-release active films by incorporation of Scrophularia striata Boiss. extract

Cited by 77 publications

References 41 publications

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

Nanocellulose as a natural source for groundbreaking applications in materials science: Today’s state

Latest Advances on Bacterial Cellulose‐Based Materials for Wound Healing, Delivery Systems, and Tissue Engineering

Engineering Bacterial Cellulose for Diverse Biomedical Applications

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