Development of back-extraction and recyclability routes for ionic-liquid-based aqueous two-phase systems

Cláudio, Ana Filipa M.; Marques, Carolina S.; Boal-Palheiros, Isabel; Freire, Mara G.; Coutinho, João A. P.

doi:10.1039/c3gc41999a

Cited by 89 publications

(78 citation statements)

References 47 publications

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“…As previously demonstrated in the literature, the hydrogenbond acidity of ILs is mainly determined by the IL cation; 10 yet, there is also a clear dependence on the IL anion, as shown here and in agreement with literature data. 10 The data presented in 15 Table 1 reveal that the ability of the IL to act as a hydrogen-bond donor (mainly arising fromthe IL cation) is moderated by the hydrogen-bond acceptor ability of the anion composing the respective IL. For instance, the dimethylphosphate-based IL, having an anion with the highest ability to accept a hydrogen 20 bond, is the one with the lowest α value.…”

Section: Resultsmentioning

confidence: 99%

“…The van der Waals energy is also accounted but in an approximate way; yet, it only depends on element specific van 15 der Waals interaction parameters.…”

Section: Cosmo-rsmentioning

confidence: 99%

“…The parameters a, b and s represent the 15 solvent-independent coefficients. 9 Different dyes and experimental approaches can result in diverse values of solvatochromic parameters for the same solvent.…”

Section: Introductionmentioning

confidence: 99%

“…14 Recently, it was demonstrated that water, 1-methylimidazole, 1-chlorobutane and the ions of the salts precursors significantly influence the values of the solvatochromic parameters of ILs. 10,15 One of the major advantages of ILs over the traditional solvents is their lack 40 of vapour pressure at ambient conditions. However, this low volatility doesn't allow their purification by simple distillation.…”

Section: Introductionmentioning

confidence: 99%

“…Table 3 lists the COSMO-RS hydrogen-bonding interaction energies for an extended number of IL anions in a decreasing order of hydrogen-bond basicity. 15 The information provided in Table 3 henceforward can be used to understand the effect of different IL anions towards chemicalmediated processes. This extended polarity scale of the ability of the IL anion to hydrogen-bond can provide a priori information to select an improved IL for a specific application before 20 extensive and time-consuming experiments.…”

mentioning

confidence: 99%

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Extended scale for the hydrogen-bond basicity of ionic liquids

Cláudio

Swift

Hallett

et al. 2014

Phys. Chem. Chem. Phys.

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223

234

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5In the past decade, ionic liquids (ILs) have been the focus of intensive research regarding their use as potential and alternative solvents in many chemical applications. Targeting their effectiveness, recent investigations have attempted to establish polarity scales capable of ranking ILs according to their chemical behaviours. However, some major drawbacks have been found since polarity scales are only report relative behaviours because they depend on the set of probe dyes used, and they are sensitive to 10 measurement conditions such as purity levels of the ILs and procedures employed.. Due to all these difficulties it is of crucial importance to find alternative and/or predictive methods and to evaluate them as a priori approaches able to provide the chemical properties of ILs. Furthermore, the large number of ILs available makes their experimental characterization, usually achieved by a trial and error methodology, burdensome. In this context, we firstly evaluated COSMO-RS, Conductor-Like Screening

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Section: Resultsmentioning

confidence: 99%

“…The van der Waals energy is also accounted but in an approximate way; yet, it only depends on element specific van 15 der Waals interaction parameters.…”

Section: Cosmo-rsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Extended scale for the hydrogen-bond basicity of ionic liquids

Cláudio

Swift

Hallett

et al. 2014

Phys. Chem. Chem. Phys.

Self Cite

223

234

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Ionic Liquids in Separation Techniques

Demissie,

Ajibade,

Mulu

et al. 2023

Handbook of Ionic Liquids

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Partitioning in aqueous two‐phase systems: Analysis of strengths, weaknesses, opportunities and threats

Soares

Azevedo

Alstine

et al. 2015

Biotechnology Journal

129

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For half a century aqueous two-phase systems (ATPSs) have been applied for the extraction and purification of biomolecules. In spite of their simplicity, selectivity, and relatively low cost they have not been significantly employed for industrial scale bioprocessing. Recently their ability to be readily scaled and interface easily in single-use, flexible biomanufacturing has led to industrial re-evaluation of ATPSs. The purpose of this review is to perform a SWOT analysis that includes a discussion of: (i) strengths of ATPS partitioning as an effective and simple platform for biomolecule purification; (ii) weaknesses of ATPS partitioning in regard to intrinsic problems and possible solutions; (iii) opportunities related to biotechnological challenges that ATPS partitioning may solve; and (iv) threats related to alternative techniques that may compete with ATPS in performance, economic benefits, scale up and reliability. This approach provides insight into the current status of ATPS as a bioprocessing technique and it can be concluded that most of the perceived weakness towards industrial implementation have now been largely overcome, thus paving the way for opportunities in fermentation feed clarification, integration in multi-stage operations and in single-step purification processes.

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Development of back-extraction and recyclability routes for ionic-liquid-based aqueous two-phase systems

Cited by 89 publications

References 47 publications

Extended scale for the hydrogen-bond basicity of ionic liquids

Extended scale for the hydrogen-bond basicity of ionic liquids

Ionic Liquids in Separation Techniques

Partitioning in aqueous two‐phase systems: Analysis of strengths, weaknesses, opportunities and threats

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