Development of Auricular Transcutaneous Vagal Stimulation Device Integrated with Signal Monitoring

Lopes, Eugênia Gonzales; Tobaldini, Eleonora; Montano, Nicola; Casali, Karina Rabello; Amorim, Henrique Alves de

doi:10.1007/978-3-030-30648-9_78

Cited by 2 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…( A ) Testing the first stage of the circuit on the simulator: the 555 mi-crocontroller is used in a stable mode to activate a voltage doubler. ( B ) The integrated 555 circuit is connected to the doubler and switching circuit [ 20 , 27 ]. ( C ) LTspice software simulation of the board incorporating the pulse generation module.…”

Section: Appendix A1 Steps Of the Algorithm (Stage 0)mentioning

confidence: 99%

“…Individual results of the PGC block used in this article were tested and validated in previous works within our research group [20,27]. The model of the pulse train generation circuit was proposed and simulated, assembled on a breadboard and validated by visualizing the frequencies of interest using an oscilloscope (Appendix B).…”

Section: Pulse Generation Circuit (Pgc) With Voltage Regulation and S...mentioning

confidence: 99%

“…The accurate detection of the end of inspiration and the start of expiration has been investigated by other researchers as well [ 14 , 19 ]. In order to synchronize the moment of stimulation triggering and to optimize the effects of vagal modulation through transcutaneous stimulation, our research team developed a mathematical model [ 20 ]. The online processing steps applied to the recorded respiratory signal highlight the complexity of managing signal variations and irregular patterns [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Advances in Non-Invasive Neuromodulation: Designing Closed-Loop Devices for Respiratory-Controlled Transcutaneous Vagus Nerve Stimulation

de Faria,

Lopes,

Tobaldini

et al. 2023

Healthcare

Self Cite

View full text Add to dashboard Cite

Studies suggest non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) as a potential therapeutic option for various pathological conditions, such as epilepsy and depression. Exhalation-controlled taVNS, which synchronizes stimulation with internal body rhythms, holds promise for enhanced neuromodulation, but there is no closed-loop system in the literature capable of performing such integration in real time. In this context, the objective was to develop real-time signal processing techniques and an integrated closed-loop device with sensors to acquire physiological data. After a conditioning stage, the signal is processed and delivers synchronized electrical stimulation during the patient’s expiratory phase. Additional modules were designed for processing, software-controlled selectors, remote and autonomous operation, improved analysis, and graphical visualization. The signal processing method effectively extracted respiratory cycles and successfully attenuated signal noise. Heart rate variability was assessed in real time, using linear statistical evaluation. The prototype feedback stimulator device was physically constructed. Respiratory peak detection achieved an accuracy of 90%, and the real-time processing resulted in a small delay of up to 150 ms in the detection of the expiratory phase. Thus, preliminary results show promising accuracy, indicating the need for additional tests to optimize real-time processing and the application of the prototype in clinical studies.

show abstract

Section: Appendix A1 Steps Of the Algorithm (Stage 0)mentioning

confidence: 99%

Section: Pulse Generation Circuit (Pgc) With Voltage Regulation and S...mentioning

confidence: 99%