Development of antifungal fibrous ocular insert using freeze-drying technique
Hoda E. Teba,
Islam A. Khalil,
Rana M. Gebreel
et al.
Abstract:Candida species is one of the pathogenic fungi of the eye responsible for keratitis that frequently causes vision impairment and blindness. Effective treatment requires long-term use of antifungal drugs, which is opposed by the defensive mechanisms of the eye and inadequate corneal penetration. The objective of this study was to develop a carrier for prolonged ocular application of fluconazole (FLZ) to treat keratitis. FLZ was encapsulated into chitosan fibrous matrices (F1–F4) using different chitosan concent… Show more
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