Development of anticancer drugs based on the hallmarks of tumor cells

Bailón-Moscoso, Natalia; Romero-Benavides, Juan Carlos; Ostrosky‐Wegman, Patricia

doi:10.1007/s13277-014-1649-y

Cited by 31 publications

(20 citation statements)

References 176 publications

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“…Natural compounds with anticancer activities derived from various habitats have been shown to modulate multiple molecular targets affecting numerous “signaling and regulatory pathways ultimately leading to tumor cell death” [546, 547]. They affect numerous targets including transcriptional factors, epigenetic regulators, regulators of mammalian target of rapamycin pathway, intrinsic and extrinsic apoptosis, cell cycle regulators, ligand-dependent receptor activators, and oxidative stress modulators leading to cell cycle arrest, apoptosis, necroptosis, and autophagy [264, 542, 548].…”

Section: Resultsmentioning

confidence: 99%

Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression

Ratovitski¹

2017

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Accumulating evidence shows that hallmarks of cancer include: “genetic and epigenetic alterations leading to inactivation of cancer suppressors, overexpression of oncogenes, deregulation of intracellular signaling cascades, alterations of cancer cell metabolism, failure to undergo cancer cell death, induction of epithelial to mesenchymal transition, invasiveness, metastasis, deregulation of immune response and changes in cancer microenvironment, which underpin cancer development”. Natural compounds as bioactive ingredients isolated from natural sources (plants, fungi, marine life forms) have revolutionized the field of anticancer therapeutics and rapid developments in preclinical studies are encouraging. Natural compounds could affect the epigenetic molecular mechanisms that modulate gene expression, as well as DNA damage and repair mechanisms. The current review will describe the latest achievements in using naturally produced compounds targeting epigenetic regulators and modulators of gene transcription in vitro and in vivo to generate novel anticancer therapeutics.

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Section: Resultsmentioning

confidence: 99%

Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression

Ratovitski¹

2017

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“…Higher selectivity is achieved by inhibiting processes to which certain cancer cells are highly dependent [20], such as using kinase inhibitors to block inappropriate signal transduction from intra-or inter-cellular signaling or using hormone modulators that inhibit hormone synthesis or block specific receptors. Other drugs like interleukin 2, Toll-like receptor agonists, or monoclonal antibodies (mAbs) can be used to stimulate the antitumor immune response.…”

Section: Current Anticancer Chemotherapymentioning

confidence: 99%

Repurposing of Anticancer Drugs for the Treatment of Bacterial Infections

Soo

Kwan

Quezada

et al. 2017

CTMC

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Despite the fact that bacterial infections are one of the leading causes of death worldwide and that mortality rates are increasing at alarming rates, no new antibiotics have been produced by the pharmaceutical industry in more than a decade. The situation is so dire that the World Health Organization warned that we may enter a "post-antibiotic era" within this century; accordingly, bacteria resistant against all known antibiotics are becoming common and already producing untreatable infections. Although several novel approaches to combat bacterial infections have been proposed, they have yet to be implemented in clinical practice. Hence, we propose that a more plausible and faster approach is the utilization of drugs originally developed for other purposes besides antimicrobial activity. Among these are some anticancer molecules proven effective in vitro for eliminating recalcitrant, multidrug tolerant bacteria; some of which also protect animals from infections and recently are undergoing clinical trials. In this review, we highlight the similarities between cancer cells/tumors and bacterial infections, and present evidence that supports the utilization of some anticancer drugs, including 5-fluorouracil (5-FU), gallium (Ga) compounds, and mitomycin C, as antibacterials. Each of these drugs has some promising properties such as broad activity (all three compounds), dual antibiotic and antivirulence properties (5-FU), efficacy against multidrug resistant strains (Ga), and the ability to kill metabolically dormant persister cells which cause chronic infections (mitomycin C).

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“…Natural compounds play an important role in the discovery novel components that can be successfully used in numerous biomedical applications, including anticancer therapeutics [1-5]. More than 60% of currently used anticancer agents are derived from natural sources supporting the notion that natural compounds are high-impact sources of new “lead compounds” or new potential therapeutic agents [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies

et al. 2017

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Natural compounds from various plants, microorganisms and marine species play an important role in the discovery novel components that can be successfully used in numerous biomedical applications, including anticancer therapeutics. Since uncontrolled and rapid cell division is a hallmark of cancer, unraveling the molecular mechanisms underlying mitosis is key to understanding how various natural compounds might function as inhibitors of cell cycle progression. A number of natural compounds that inhibit the cell cycle arrest have proven effective for killing cancer cells in vitro, in vivo and in clinical settings. Significant advances that have been recently made in the understanding of molecular mechanisms underlying the cell cycle regulation using the chemotherapeutic agents is of great importance for improving the efficacy of targeted therapeutics and overcoming resistance to anticancer drugs, especially of natural origin, which inhibit the activities of cyclins and cyclin-dependent kinases, as well as other proteins and enzymes involved in proper regulation of cell cycle leading to controlled cell proliferation.

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Development of anticancer drugs based on the hallmarks of tumor cells

Cited by 31 publications

References 176 publications

Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression

Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression

Repurposing of Anticancer Drugs for the Treatment of Bacterial Infections

Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies

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