Development of Antibiofilm Nanocomposites: Ag/Cu Bimetallic Nanoparticles Synthesized on the Surface of Graphene Oxide Nanosheets

Jang, Jaesung; Lee, Jong Min; Oh, Seoyeah; Choi, Yonghyun; Jung, Han‐Sung; Choi, Jonghoon

doi:10.1021/acsami.0c06054

Cited by 49 publications

(35 citation statements)

References 45 publications

(64 reference statements)

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“…8 Cheng et al 9 loaded ceria nanoparticles on graphene nanocomposites and observed enhanced antibacterial properties against E. coli and Staphylococcus aureus because of numerous reactive oxygen species, which originated from the excellent photoinduced electrons and holes' separation ability in that composite. Similar results were obtained by Jang et al 13 to remove several bacterial species and biofilms by bimetallic Ag/Cu nanoparticles decorated on GO flakes because of the two metal ions' release over time. Moreover, Akhavan and Ghaderi 19 suggested that the sharp edges of the sheets are responsible for cell rupture.…”

Section: Introductionsupporting

confidence: 87%

“…Not only was it harmless to mammalian cells, but it was toxic enough to inhibit the growth of pathogenic bacteria such as Escherichia coli. , Later, graphene and its derivatives with and without functionalization and hybrid components such as Ag and Au were tested for bactericidal effects. Considering the high rate of hospital-acquired infections (the sixth leading cause of death in hospitals), G/GO antibacterial agents seem to be promising candidates to stop bacteria’s proliferation in such environments. − …”

Section: Introductionmentioning

confidence: 99%

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Molecular Machinery Responsible for Graphene Oxide’s Distinct Inhibitory Effects toward Pseudomonas aeruginosa and Staphylococcus aureus Pathogens

Astani

Najafi

Maghsoumi

et al. 2020

ACS Appl. Bio Mater.

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Graphene oxide flakes are considered as potential inhibitors for different pathogenic bacteria. However, the efficacy of inhibition changes for different types and strains of bacteria. In this work, we examine Pseudomonas aeruginosa and Staphylococcus aureus, two common hospital-acquired infections, which react quite differently to graphene oxide flakes. The minimum inhibitory tests yield two distinct outcomes: stopped proliferation for S. aureus versus almost no effect for P. aeruginosa. Integrating our experimental evidence with molecular dynamics simulations, we elucidate the molecular machinery involved, explaining the behavior we see in scanning electron microscopy images. According to our simulations, the peptidoglycan network, the outermost layer of S. aureus, is completely entangled with the flakes, acting as a hunting ground, which consequently results in the inhibition of the pathogen itself. Lipopolysaccharides, the outermost layer of P. aeruginosa, on the other hand, resist interacting with the flakes. Lipopolysaccharides make no effective contacts, and thus, no effective inhibition of the pathogen takes place. Likewise, the electron microscopy images show a complete coverage and wrapping of S. aureus. In contrast, for P. aeruginosa, barely any bacteria are spotted with any flakes on top except for some loosely half-covered cases. As we did not observe any damaged bacteria in our images, we exclude the knife-cutting inhibition mechanism and suggest the wrapping and trapping mechanism for S. aureus for our flakes’ rather large size (an average area of 0.05 μm2). The molecular machinery suggested in this work can be used for molecular engineering and functionalizing graphene flakes to inhibit different pathogens.

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Section: Introductionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Molecular Machinery Responsible for Graphene Oxide’s Distinct Inhibitory Effects toward Pseudomonas aeruginosa and Staphylococcus aureus Pathogens

Astani

Najafi

Maghsoumi

et al. 2020

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…48 Moreover, another study has documented that Ag/Cu/GO nanocomposite inhibited the biolm formation of P. aeruginosa at the concentration which was harmless to human cells. 49 Our ndings clearly show the ability of TiO 2 -NPs in inhibiting the biolms of both Gram +ve and Gram Àve bacteria.…”

Section: Microscopic Analysis Of Biolms Inhibition On Glass Surface Usingmentioning

confidence: 70%

Effective inhibition and eradication of pathogenic biofilms by titanium dioxide nanoparticles synthesized using Carum copticum extract

et al. 2021

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“…The nanosystem revealed similar efficacy against S. aureus biofilm with commercial Acticoat Flex 3 (a silver-coated dressing) in an engineered tissue infection skin model. Copper was combined with silver to form bimetallic nanoparticles for antibiofilm treatment [122]. The average diameter of the nanoparticles was about 7 nm.…”

Section: Topically Applying Nanoparticles To Treat Cutaneous Biofilms 61 Metallic Nanoparticlesmentioning

confidence: 99%

The Antibiofilm Nanosystems for Improved Infection Inhibition of Microbes in Skin

et al. 2021

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Biofilm formation is an important virulence factor for the opportunistic microorganisms that elicit skin infections. The recalcitrant feature of biofilms and their antibiotic tolerance impose a great challenge on the use of conventional therapies. Most antibacterial agents have difficulty penetrating the matrix produced by a biofilm. One novel approach to address these concerns is to prevent or inhibit the formation of biofilms using nanoparticles. The advantages of using nanosystems for antibiofilm applications include high drug loading efficiency, sustained or prolonged drug release, increased drug stability, improved bioavailability, close contact with bacteria, and enhanced accumulation or targeting to biomasses. Topically applied nanoparticles can act as a strategy for enhancing antibiotic delivery into the skin. Various types of nanoparticles, including metal oxide nanoparticles, polymeric nanoparticles, liposomes, and lipid-based nanoparticles, have been employed for topical delivery to treat biofilm infections on the skin. Moreover, nanoparticles can be designed to combine with external stimuli to produce magnetic, photothermal, or photodynamic effects to ablate the biofilm matrix. This study focuses on advanced antibiofilm approaches based on nanomedicine for treating skin infections. We provide in-depth descriptions on how the nanoparticles could effectively eliminate biofilms and any pathogens inside them. We then describe cases of using nanoparticles for antibiofilm treatment of the skin. Most of the studies included in this review were supported by in vivo animal infection models. This article offers an overview of the benefits of nanosystems for treating biofilms grown on the skin.

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Development of Antibiofilm Nanocomposites: Ag/Cu Bimetallic Nanoparticles Synthesized on the Surface of Graphene Oxide Nanosheets

Cited by 49 publications

References 45 publications

Molecular Machinery Responsible for Graphene Oxide’s Distinct Inhibitory Effects toward Pseudomonas aeruginosa and Staphylococcus aureus Pathogens

Molecular Machinery Responsible for Graphene Oxide’s Distinct Inhibitory Effects toward Pseudomonas aeruginosa and Staphylococcus aureus Pathogens

Effective inhibition and eradication of pathogenic biofilms by titanium dioxide nanoparticles synthesized using Carum copticum extract

The Antibiofilm Nanosystems for Improved Infection Inhibition of Microbes in Skin

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