Development of antibacterial peptides with efficient antibacterial activity, low toxicity, high membrane disruptive activity and a synergistic antibacterial effect

Abstract

It is urgent to develop new antimicrobial drugs to overcome bacterial resistance which is a serious threat to human health. Antimicrobial peptides (AMPs) which are ideal substitutes for traditional antibiotics...

A new surfactin-C17 produced by Bacillus subtilis TD7 with a low critical micelle concentration and high biological activity

“…12–14 In addition to being a kind of biosurfactant, surfactin also exhibited hemolytic, anticoagulant, antimicrobial, and antitumoral activities. 15–17 Due to its outstanding surface properties and special bioactivities, surfactin has attracted much attention from the pharmaceutical, bioremediation, microbial enhanced oil recovery, and many other industrial communities. 18,19 Nevertheless, our knowledge about the structural diversity of surfactins and the role of different members is still limited.…”

“…[12][13][14] In addition to being a kind of biosurfactant, surfactin also exhibited hemolytic, anticoagulant, antimicrobial, and antitumoral activities. [15][16][17]…”

Probing the Gelation Synergies and Anti-Escherichia coli Activity of Fmoc-Phenylalanine/Graphene Oxide Hybrid Hydrogel

“…In addition, they have high water content and combine low toxicity (high biocompatibility toward mammalian cells) with antimicrobial activity. Their activity can be either inherent or, for example, caused by incorporating antimicrobial agents within the gel matrix, which can increase their spectrum of activity. , Recently, several amino acid and peptide-based supramolecular gels have been introduced, of which the N -fluorenylmethyloxycarbonyl (Fmoc)-protected analogues have shown high application potential. − …”

Screening and investigation of a short antimicrobial peptide: AVGAV

“…However, most of the antimicrobial peptides in the clinical trial process are derived from humans or various animals, which limits the diversity of peptides and increases the risk of bacteria developing resistance by evolving. 7,8 Therefore, it is necessary to develop synthetic antimicrobial peptides.…”