Development of antibacterial contact lenses containing metallic nanoparticles

Kharaghani, Davood; Dutta, Debarun; Gitigard, Parastoo; Tamada, Yasushi; Katagiri, Anna; Phan, Duy-Nam; Willcox, Mark

doi:10.1016/j.polymertesting.2019.106034

Cited by 34 publications

(32 citation statements)

References 50 publications

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“…Silver-containing contact lens cases are commercially available and have been shown in several in vitro [319,[482][483][484][485][486] and in vivo [486,487] studies to reduce the colonisation of cases by bacteria and fungi. Not surprisingly, given the demonstrated efficacy of silver-impregnated contact lens cases to reduce microbial colonisation, silver impregnated contact lenses (or surrogates) have also been developed [106,[488][489][490][491][492][493][494][495][496][497][498][499][500][501][502][503][504]. Various strategies have been used to produce the silver-containing contact lenses, including sputter-coating onto lens surfaces [503], incorporation or production of (nano)particles during lens production [497,499,501,502] or imbibition into lenses [490,498], associated with various types of coating technologies [496,500].…”

Section: Antimicrobial Coatingsmentioning

confidence: 99%

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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Contact lens materials have undergone significant changes over the past 20 years, particularly with respect to the introduction of silicone hydrogel materials. Whilst this development addressed hypoxic issues, other important areas relating to contact lens success, notably comfort, require further research.Contact lens wettability remains a crucially important part of biocompatibility. Contact lenses can be made more wettable by incorporation of surfactants into blister packs, internal wetting agents, surface treatments or care solutions. However, there remains no clear association between contact lens wettability and comfort, making it challenging to determine the potential for these approaches to be of significant clinical benefit. Most contact lenses are used on a daily wear, reusable basis, which requires them to be disinfected when not worn. The ideal disinfecting solution would also improve comfort during wear. However, balancing these requirements with other factors, including biocompatibility, remains a challenge. Soft lens materials invariably take up and subsequently release certain components of disinfecting solutions onto the ocular surface. This may affect tear film stability and the normal ocular microbiome, and further research is needed in this area to determine whether this has any affect on comfort. Finally, contact lens materials sorb components of the tear film, and these interactions are complex and may change the biochemistry of the tear film, which in turn may affect their comfort.In conclusion, the interaction between lens materials, tear film and disinfection solution plays an important role in the biocompatibility of lenses. However, the exact role and whether this can be altered to improve biocompatibility and comfort during wear remains debatable. This report summarises the best available evidence to examine this complex relationship and the opportunities for practitioners to enhance in-eye comfort of contemporary lenses, along with providing suggestions for areas of study that may provide further information on this topic.

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Section: Antimicrobial Coatingsmentioning

confidence: 99%

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Willcox

Keir

Maseedupally

et al. 2021

Contact Lens and Anterior Eye

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“…As a hydrophilic surface immersed in the interface between an aquatic environment and the atmosphere, SCL are not only a barrier between the corneal epithelium and oxygen, but also an optimal hotbed of bacterial incubation. In previous studies in SCL biofouling [ 16 , 67 , 68 , 70 , 73 , 74 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 ], the relationship between SCL physical properties and susceptibility to microbial adsorption have been discussed and analyzed to conceive specialized antibacterial strategies.…”

Section: Prospects For the Development Of Biomimetic Bactericidal mentioning

confidence: 99%

Biomimetic Functional Surfaces towards Bactericidal Soft Contact Lenses

Mao

2020

Micromachines

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The surface with high-aspect-ratio nanostructure is observed to possess the bactericidal properties, where the physical interaction between high-aspect-ratio nanostructure could exert sufficient pressure on the cell membrane eventually lead to cell lysis. Recent studies in the interaction mechanism and reverse engineering have transferred the bactericidal capability to artificial surface, but the biomimetic surfaces mimicking the topographical patterns on natural resources possess different geometrical parameters and surface properties. The review attempts to highlight the recent progress in bactericidal nanostructured surfaces to analyze the prominent influence factors and cell rupture mechanism. A holistic approach was utilized, integrating interaction mechanisms, material characterization, and fabrication techniques to establish inclusive insights into the topographical effect and mechano-bactericidal applications. The experimental work presented in the hydrogel material field provides support for the feasibility of potentially broadening applications in soft contact lenses.

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“…[14,29] Also, it has acceptable mechanical properties, high oxygen permeability, and low protein folding. [30][31][32][33][34] HA delivery via CLs for dry eye treatment has been investigated by a wide array of studies. For instance, Ali et al employed a biomimetic strategy to incorporate HA in a PVA hydrogel via molecular imprinting technique in order to attain an HA sustained-releasing system.…”

Section: Introductionmentioning

confidence: 99%

“…[ 14,29 ] Also, it has acceptable mechanical properties, high oxygen permeability, and low protein folding. [ 30–34 ]…”

Section: Introductionmentioning

confidence: 99%

Preparation of Nanoparticle‐Containing Ring‐Implanted Poly(Vinyl Alcohol) Contact Lens for Sustained Release of Hyaluronic Acid

Akbari

Imani

Shokrollahi

et al. 2021

Macromolecular Bioscience

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Here, a novel ring-implanted poly vinyl alcohol (PVA) contact lens (CL) is fabricated and evaluated as a therapeutic CL with potential of sustained release of hyaluronic acid (HA). HA is loaded on chitosan (CS) nanoparticles (NPs) and then the HA-loaded NPs are dispersed in a ring shape PVA hydrogel which is implanted in the final PVA CL. Results show that HA is successfully loaded on NPs (520 ± 18 nm) with loading efficacy of 87% and loading capacity of 50%. The CL hydrogel has a 275% swelling ratio, no degradation during 14 days, 97% light transmittance, and desirable rheological stability under physiological shear force. The release data show a sustained release for HA from the ring implanted CL up to 14 days. The cellular study reveals no corneal epithelial cell cytotoxicity and cell attachment on the CL. The study demonstrates the successful application of the ring-implanted CL to sustain the delivery of HA for treating the dry eye syndrome.

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Development of antibacterial contact lenses containing metallic nanoparticles

Cited by 34 publications

References 50 publications

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

BCLA CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears

Biomimetic Functional Surfaces towards Bactericidal Soft Contact Lenses

Preparation of Nanoparticle‐Containing Ring‐Implanted Poly(Vinyl Alcohol) Contact Lens for Sustained Release of Hyaluronic Acid

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