Development of anti-biofouling interface on hydroxyapatite surface by coating zwitterionic MPC polymer containing calcium-binding moieties to prevent oral bacterial adhesion

Polymeric materials and films in dentistry: An overview

“…MPC reduced the retention of human pathogenic microorganisms [92] . Kang et al [93] immobilized MPC on the tooth surface to prevent oral bacterial adhesion. The synthesized MPC-ran-2-methacryloyloxyethyl phosphate (PMP) copolymer with zwitterionic and Ca 2+ binding moieties formed a highly effective biofilm inhibiting surface on the HA of the tooth surface.…”

<p>Anti-Biofouling Coatings on the Tooth Surface and Hydroxyapatite</p>

“…International Journal of Nanomedicine 2020:15 furanone C-30 (against antibiotic-resistant bacteria) to achieve a sufficient sustained release of drug concentrations, and PBMP contains Ca 2+ -binding phosphomonoester groups to adhere to HA (Figure 7). 14,15,48,97,98 Furanone C-30 as a halogenated furanone antibacterial compound can effectively inhibit bacterial quorum sensing (QS) by interfering with N-acyl homoserine lactone or luxS signals, which were used to coordinate bacterial population behavior during infection and biofilm formation. 99,100 In addition, furanones were often used to encapsulate lactide polymer-based microparticles or nanoparticles.…”

Understanding the Role of Shape and Composition of Star-Shaped Polymers and their Ability to Both Bind and Prevent Bacteria Attachment on Oral Relevant Surfaces

“…The control and reduction of oral biofilm formation [1], initiated by bacterial species living in polymicrobial, pathogenic colonies at or below the gingival margin [2], are critical steps toward the prevention of dental caries and periodontal diseases [3][4][5]. While many methods have been proposed to prevent or treat these biofilms [6][7][8][9][10], one promising strategy is the use of synthetic polymer additives that bind to the tooth surface to act as a barrier or deterrent to the deposition of planktonic bacteria through either lethal [11][12][13] or non-lethal [14,15] mechanisms. Dental materials, especially those delivered from common over the counter products such as toothpaste or mouthwash, must effectively be multifunctional materials in that they must (1) deposit and stick to a tooth surface, (2) act as a barrier against bacteria attachment, (3) be robust against external challenges such as food and drink in order to not require constant reapplication, and (4) perform steps 1-3 in the presence of the salivary pellicle.…”