Development of anemia, phlebotomy practices, and blood transfusion requirements in 45 critically ill cats (2009–2011)

Balakrishnan, Anusha; Drobatz, Kenneth J.; Reineke, Erica L.

doi:10.1111/vec.12363

Cited by 19 publications

(24 citation statements)

References 31 publications

(55 reference statements)

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“…Limited information is available hospital‐acquired anemia development in critically ill animals. One small retrospective study documented anemia in 74% of cats that were not anemic at the time of admission to an ICU . These cats tended to be hospitalized longer, and required more blood products.…”

contrasting

confidence: 87%

“…By the end of hospitalization, anemia was more common however with a prevalence of 56.3%. The extent of hospital‐acquired anemia described in this study is lower than previously reported in critically ill people (70% within 48 hours of admission to an ICU) and in a retrospective study of cats (84.4%) . This apparent lack of agreement may be because of disparity in the severity of patient illness, with the previous studies in people and cats potentially describing a cohort of more severely affected individuals.…”

Section: Discussionmentioning

confidence: 99%

“…The extent of hospital-acquired anemia described in this study is lower than previously reported in critically ill people (70% within 48 hours of admission to an ICU) 12 and in a retrospective study of cats (84.4%). 17 This apparent lack of agreement may be because of disparity in the severity of patient illness, with the previous studies in people and cats potentially describing a cohort of more severely affected individuals. Regrettably, an illness severity score was not determined for the animals enrolled in our study because of inconsistent availability of data required to formulate such a score.…”

Section: Discussionmentioning

confidence: 99%

“…One small retrospective study documented anemia in 74% of cats that were not anemic at the time of admission to an ICU. 17 These cats tended to be hospitalized longer, and required more blood products. The purpose of our study was to identify the prevalence of hospital-acquired anemia in critically ill dogs and cats managed in ICUs of 3 veterinary teaching hospitals.…”

mentioning

confidence: 99%

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Hospital‐acquired Anemia in Critically Ill Dogs and Cats: A Multi‐Institutional Study

Lynch

Respess

Boll

et al. 2015

Veterinary Internal Medicne

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BackgroundHospital‐acquired anemia is commonly described in people but limited information currently is available regarding its prevalence in animals.Hypothesis/objectivesAssess the prevalence of hospital‐acquired anemia in hospitalized critically ill dogs and cats, and examine its relationship with phlebotomy practices, transfusion administration, and survival to discharge.AnimalsEight hundred and fifty‐one client‐owned animals (688 dogs and 163 cats).MethodsA multicenter, observational study was conducted in which packed cell volume (PCV) was recorded at the time of admission and on subsequent hospitalization days. Signalment, number of blood samples obtained, underlying disease, whether or not blood products were administered, duration of hospitalization, and survival to discharge were recorded.ResultsAdmission anemia prevalence was 32%, with overall prevalence during the hospitalization period of 56%. The last recorded PCV was significantly lower than the admission PCV for both dogs (admission PCV, 42% [range, 6–67%]; last recorded PCV, 34% [range, 4–64%], P < .0001) and cats (admission PCV, 31% [range, 6–55%]; last recorded PCV, 26% [range, 10–46%], P < .0001). Patients that developed anemia had significantly more blood samples obtained (nonanemic, 5 blood samples [range, 2–54]; anemic, 7 blood samples [range, 2–49], P < .0001). Hospitalized cats were significantly more likely to develop anemia compared to dogs (P < .0001), but anemic dogs were significantly less likely to survive to discharge (P = .0001). Surgical patients were at higher risk of developing hospital‐acquired anemia compared to medical patients (OR, 0.63; 95% CI, 0.4–0.9; P = .01).Conclusions and Clinical RelevanceHospital‐acquired anemia occurred frequently, especially in surgical patients. Additional studies focused on the direct effect of phlebotomy practices on the likelihood of anemia development in hospitalized animals are warranted.

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contrasting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Hospital‐acquired Anemia in Critically Ill Dogs and Cats: A Multi‐Institutional Study

Lynch

Respess

Boll

et al. 2015

Veterinary Internal Medicne

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“…This cat additionally had a drop in PCV from 34% to 22% at 24 hours after transfusion, as well as a new onset Heinz body anemia. Other causes of hemolysis in this cat were unlikely and included microbial contamination of the transfused unit, repeated blood sampling, underlying systemic disease or administration of drugs resulting in Heinz body hemolytic anemia, or hemolysis secondary to use of a mechanical delivery system . This suggests that the transfusion of a major cross‐match compatible unit of pRBCs might not completely eliminate the risk of HTR.…”

Section: Discussionmentioning

confidence: 94%

Effect of cross‐match on packed cell volume after transfusion of packed red blood cells in transfusion‐naïve anemic cats

Sylvane

Prittie

Hohenhaus

et al. 2018

Veterinary Internal Medicne

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BackgroundNovel feline RBC antigens might contribute to decreased efficacy of RBC transfusion and increased incidence of acute transfusion reactions (ATR).ObjectivesTo examine the effect of major cross‐match in transfusion‐naïve anemic cats on the incidence of acute immunologic transfusion reaction and transfusion efficacy for up to 24 hours after transfusion.AnimalsForty‐eight client owned transfusion‐naïve anemic cats.MethodsProspective, randomized, controlled study. All transfusion‐naïve cats receiving packed red blood cells (pRBC) transfusions from January 2016 to August 2017 were eligible for inclusion. Cats in the study group received cross‐match and blood type compatible pRBCs and cats in the control group received noncross‐matched blood type compatible pRBCs. Incidence of ATR and change in PCV after transfusion was recorded.ResultsNo significant difference in incidence of transfusion reactions between cross‐matched and noncross‐matched groups (CM+ 4/24; 17%, CM– 7/24; 29%, P = .16). No significant difference between groups in mean change in PCV after transfusion scaled to dose of pRBCs administered at any time point after transfusion (immediate: CM+ 0.62 ± 0.59, CM– 0.75 ± 0.48, P = .41; 1 hour: CM+ 0.60 ± 0.66, CM– 0.74 ± 0.53, P = .43; 12 hours: CM+ 0.70 ± 0.55, CM– 0.66 ± 0.60, P = .81; 24 hours: CM+ 0.64 ± 0.71, CM– 0.55 ± 0.48, P = .70).Conclusions and Clinical ImportanceOur results do not support use of the major cross‐match test to increase efficacy of, and to decrease adverse events associated with, RBC transfusion in AB blood typed transfusion‐naïve cats.

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Limiting Allogenic Blood Transfusions

Holowaychuk

2016

Manual of Veterinary Transfusion Medicine and Blood Banking

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Development of anemia, phlebotomy practices, and blood transfusion requirements in 45 critically ill cats (2009–2011)

Cited by 19 publications

References 31 publications

Hospital‐acquired Anemia in Critically Ill Dogs and Cats: A Multi‐Institutional Study

Hospital‐acquired Anemia in Critically Ill Dogs and Cats: A Multi‐Institutional Study

Effect of cross‐match on packed cell volume after transfusion of packed red blood cells in transfusion‐naïve anemic cats

Limiting Allogenic Blood Transfusions

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