Development of andrographolide-loaded solid lipid nanoparticles for lymphatic targeting: Formulation, optimization, characterization, in vitro, and in vivo evaluation

Shrivastava, SaurabhRamBihariLal; Kaur, Chanchal Deep

doi:10.1007/s13346-022-01230-6

Cited by 9 publications

(2 citation statements)

References 34 publications

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“…For example, bioavailability of AG was improved when it was administered in the forms of nanoemulsion vesicles and pH-sensitive nanoparticles [ 251 , 255 ]. Additionally, administration of AG niosomes and nanosuspensions can help target the liver [ 266 , 267 ]. However, some delivery systems have shortcomings.…”

Section: Discussionmentioning

confidence: 99%

Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases

Gou

et al. 2023

Journal of Pharmaceutical Analysis

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Section: Discussionmentioning

confidence: 99%

Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases

Gou

et al. 2023

Journal of Pharmaceutical Analysis

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“…This was carried out on an XPERT-PRO diffractometer system at 2θ angles from 4 • to 50 • . The copper was employed as anode material, and K α and K β radiations were observed at 45 kV (tube voltage) and 40 mA (tube current) at 25 • C [54].…”

Section: X-ray Diffraction (Xrd)mentioning

confidence: 99%

Solid Lipid Nanoparticles Embedded Hydrogels as a Promising Carrier for Retarding Irritation of Leflunomide

Alhelal,

Mehta,

Kadian

et al. 2023

Gels

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Leflunomide (LEF), a disease-modifying anti-rheumatic drug, has been widely explored for its anti-inflammatory potential in skin disorders such as psoriasis and melanoma. However, its poor stability and skin irritation pose challenges for topical delivery. To surmount these issues, LEF-loaded solid lipid nanoparticles (SLNs) integrated with hydrogels have been developed in the present investigation. SLNs developed by microemulsion techniques were found ellipsoidal with 273.1 nm particle size and −0.15 mV zeta potential. Entrapment and total drug content of LEF-SLNs were obtained as 65.25 ± 0.95% and 93.12 ± 1.72%, respectively. FTIR and XRD validated the successful fabrication of LEF-SLNs. The higher stability of LEF-SLNs (p < 0.001) compared to pure drug solution was observed in photostability studies. Additionally, in vitro anti-inflammatory activity of LEF-SLNs showed good potential in comparison to pure drugs. Further, prepared LEF-SLNs loaded hydrogel showed ideal rheology, texture, occlusion, and spreadability for topical drug delivery. In vitro release from LEF-SLN hydrogel was found to follow the Korsmeyer-Peppas model. To assess the skin safety of fabricated lipidic formulation, irritation potential was performed employing the HET-CAM technique. In conclusion, the findings of this investigation demonstrated that LEF-SLN hydrogel is capable of enhancing the photostability of the entrapped drug while reducing its skin irritation with improved topical delivery characteristics.

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Multifaceted Applications of Solid Lipid: A Comprehensive Review

Patra,

Sahu,

Singha

et al. 2024

Biomedical Materials & Devices

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Development of andrographolide-loaded solid lipid nanoparticles for lymphatic targeting: Formulation, optimization, characterization, in vitro, and in vivo evaluation

Cited by 9 publications

References 34 publications

Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases

Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases

Solid Lipid Nanoparticles Embedded Hydrogels as a Promising Carrier for Retarding Irritation of Leflunomide

Multifaceted Applications of Solid Lipid: A Comprehensive Review

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