Development of an ultrasound-mediated nano-sized drug-delivery system for cancer treatment: from theory to experiment
Farshad Moradi Kashkooli,
Anshuman Jakhmola,
Graham A Ferrier
et al.
Abstract:Aim: To establish a methodology for understanding how ultrasound (US) induces drug release from nano-sized drug-delivery systems (NSDDSs) and enhances drug penetration and uptake in tumors. This aims to advance cancer treatment strategies. Materials & methods: We developed a multi-physics mathematical model to elucidate and understand the intricate mechanisms governing drug release, transport and delivery. Unique in vitro models (monolayer, multilayer, spheroid) and a tailored US exposure setup were introd… Show more
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