Development of an ultrasensitive Ru(II) complex-based fluorescent probe with phenothiazine unit for selective detection HOCl and its application in water samples

Tetraphenylethylene-Functionalized Metal–Organic Frameworks with Strong Aggregation-Induced Electrochemiluminescence for Ultrasensitive Analysis through a Multiple Convertible Resonance Energy Transfer System

“…As seen, the fluorescence lifetime of TPE-UiO-66 was 1.6951 ns (τ 1 ), which was longer than TPE’s lifetime (τ 2 = 1.389 ns). The increase in the TPE fluorescence lifetime made TPE-UiO-66 more effective for many chemical and biological applications. , The ECL spectrum of TPE-UiO-66 that is presented in Figure C was obtained by collecting the maximum ECL intensity under cyclic voltammogram scanning by using a model MPI-E electrochemiluminescence analyzer detector with a series of optical filters. The maximum ECL emission peak for TPE-UiO-66(0.35) was at 527 nm (Figure C, black curve), which overlapped extensively with the UV absorption peaks at 497 nm (Figure C, red curve) of Adriamycin (Dox).…”

Determination and Imaging of Small Biomolecules and Ions Using Ruthenium(II) Complex-Based Chemosensors

“…For the determination of HOCl, Ru(II) complex chemosensors have been developed by exploiting different response reactions, including (1) oxidation of S atom [ 188 , 189 ], (2) amines (including dibenzoylhydrazine) [ 190 , 191 ] and (3) oxime derivatives and others [ 192 , 193 ]. In 2013, Zhang et al reported a Ru(II) complex chemosensor 42 for HOCl detection and imaging [ 188 ].…”

“…The applications of complex 42 for imaging of exogenous HOCl in HeLa and endogenous HOCl in RAW 264.7 cells were then demonstrated. HOCl-mediated oxidation of phenothiazine’s “S” has also been exploited for developing Ru(II) complexes for HOCl detection in biological [ 194 ] and environmental samples [ 189 ]. For example, in 2014, Liu et al reported a Ru(II) complex 43 as the reversible chemosensor for HOCl determination and imaging (Fig.…”

Phosphorescent and Test Strips Detection Properties of ClO− Probes Based on Iridium(III) Complexes with Pivaloyl Unit as Recognition Site

“…[5b,7] As one of reactive oxygen species (ROS), hypochlorous acid/hypochlorite (HClO/ClO À ) in organism is usually generated through enzyme-catalyzed oxidation reaction between chloride and hydrogen peroxide in activated phagocytes under the assistance of myeloperoxidase (MPO). [8,9] It is a double-edged sword for organisms, because it not only plays an important role in many biological processes as an important intracellular signaling molecule, [10] but also is associated with pathogenesis of various diseases, [11] so the hypochlorous acid. For instance, it is found that the abnormal accumulation of HClO can cause extensive oxidative stress [12] and oxidative damage in human neurodegenerative diseases and further induce a series of diseases including atherosclerosis, [13] rheumatoid rheumatism, [14] cancer, [15] reperfusion injury, [16] ischemia and so on.…”