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ALB albumin, ALT alanine transaminase, AST aspartate transaminase, BMI body mass index, BSA body surface area, CL clearance, C max maximum plasma concentration, CO cardiac output, C ss plasma concentration at steady state, ELS extended least squares, FAT fat mass, FFM fat-free mass, HGT height, HV healthy volunteers, IC 50 half maximal inhibitory concentration, IIV inter-individual variability, I max maximal inhibition, IOV inter-occasion variability, LBM lean body mass, N number of subjects, PK pharmacokinetic, Q inter-compartmental clearance, SVR systemic vascular resistance, TBW total body weight, TCI target-controlled infusion, V apparent volume of distribution, WGT weight