2021
DOI: 10.1371/journal.pone.0247668
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Abstract: Human peripheral blood mononuclear cells (PBMCs) are part of the innate and adaptive immune system, and form a critical interface between both systems. Studying the metabolic profile of PBMC could provide valuable information about the response to pathogens, toxins or cancer, the detection of drug toxicity, in drug discovery and cell replacement therapy. The primary purpose of this study was to develop an improved processing method for PBMCs metabolomic profiling with nuclear magnetic resonance (NMR) spectrosc… Show more

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Cited by 3 publications
(3 citation statements)
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References 69 publications
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“…Whole blood from patients is often altered upon collection by the tubes and processing steps that come after. Serum and plasma are the most commonly analysed blood extracts but analysis can be extended to whole blood [ 181 ], platelets [ 103 ], red blood cells [ 56 ], peripheral blood mononuclear cells [ 182 ] and dried blood spots [ 183 ].…”
Section: Resultsmentioning
confidence: 99%
“…Whole blood from patients is often altered upon collection by the tubes and processing steps that come after. Serum and plasma are the most commonly analysed blood extracts but analysis can be extended to whole blood [ 181 ], platelets [ 103 ], red blood cells [ 56 ], peripheral blood mononuclear cells [ 182 ] and dried blood spots [ 183 ].…”
Section: Resultsmentioning
confidence: 99%
“…Although reports on these applications are much sparser than publications on oncological or neurological applications, they will be briefly presented in Supplementary Materials (Section SI 1.4). These investigations concern studies of blood vessel tissue, skin, ascites cells, spermatozoa, serum lipids and milk lipids (mammalian origin) [84][85][86][87][88][89][90][91]; furthermore, measurements of mussels, corals, and plants (non-mammalian origin), as well as microorganisms (bacteria, yeast and other fungi, parasites) [92][93][94][95][96][97][98][99][100][101][102][103][104][105][106][107].…”
Section: Overview Of Techniques For Particular Applications Of Metabo...mentioning
confidence: 99%
“…Moreover, it could change cell localization and phosphorylation, damage DNA, and alter BRCA1 (BReast CAncer gene 1), which is expressed in triple-negative breast cancer cells. (Guney Eskiler et al, 2020). CUR has also been shown to have synergistic antiproliferative effects when combined with other chemotherapeutic drugs or radiation (Abdallah, Helmy, Katary, & Ghoneim, 2018;Zoi et al, 2021).…”
Section: Introductionmentioning
confidence: 99%