Development of an on-chip sample injection system with a 6-port valve incorporated in a microchip

Morioka, Kazuhiro; Sato, Hiroto; Morita, Kenji; Hemmi, Akihide; Nakajima, Hirochika; Shoji, Atsushi; Yanagida, Akio

doi:10.1039/d0ra07043b

Cited by 6 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This observation was made regardless of the used printing technique and is caused by the rough surface of the 3D-printed parts which always leads to a small gap between rotor and stator, even if both parts are strongly compressed [ 21 ]. This result is consistent with reports from literature, where either lubricants like vaseline [ 20 ], teflon spray [ 19 ] or teflon wrap [ 21 ] were used or only the rotor was 3D-printed with an elastic PDMS stator that ensured sealing [ 18 , 28 ]. Further details such as microscope images regarding the structure of the sealing surfaces are given in Figure S1 in the Supplementary Materials .…”

Section: Results and Discussionsupporting

confidence: 91%

“…In former studies of 3D-printed radial valves, water leakage tests were performed but it is not specified how the systems tightness was determined [ 18 , 28 ], making the results hard to compare. In addition the tightness of one particular system may also be subject to the respective experimental setup, thus it is not common in literature as well as in manufacturer information to give the intrinsic leakage streams for dynamic sealing systems like valves.…”

Section: Results and Discussionmentioning

confidence: 99%

“…In applications where 2/2 way valves cannot be used, e.g., when connections between different channels are to be changed, the rotor-stator principle, which is also utilized in many commercial valves, is employed: Morioka et al developed a 3D-printed stator in combination with a polydimethylsiloxane (PDMS) microfluidic chip and improved the response time and minimized band-broadening effects in a flow injection analysis system [ 18 ]. Su et al developed a 3D-printed flow injection system for coupling with ICP-MS [ 19 ], Chan et al designed pump and valve systems for point-of-care diagnostics [ 20 ], and Munshi et al designed a valve for sample injection volumes as low as 195 nL [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Configurable 3D Printed Microfluidic Multiport Valves with Axial Compression

2021

View full text Add to dashboard Cite

In the last decade, the fabrication of microfluidic chips was revolutionized by 3D printing. It is not only used for rapid prototyping of molds, but also for manufacturing of complex chips and even integrated active parts like pumps and valves, which are essential for many microfluidic applications. The manufacturing of multiport injection valves is of special interest for analytical microfluidic systems, as they can reduce the injection to detection dead volume and thus enhance the resolution and decrease the detection limit. Designs reported so far use radial compression of rotor and stator. However, commercially available nonprinted valves usually feature axial compression, as this allows for adjustable compression and the possibility to integrate additional sealing elements. In this paper, we transfer the axial approach to 3D-printed valves and compare two different printing techniques, as well as six different sealing configurations. The tightness of the system is evaluated with optical examination, weighing, and flow measurements. The developed system shows similar performance to commercial or other 3D-printed valves with no measurable leakage for the static case and leakages below 0.5% in the dynamic case, can be turned automatically with a stepper motor, is easy to scale up, and is transferable to other printing methods and materials without design changes.

show abstract

Section: Results and Discussionsupporting

confidence: 91%

Section: Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Configurable 3D Printed Microfluidic Multiport Valves with Axial Compression

2021

View full text Add to dashboard Cite

show abstract

“…PP is available for 3D printing, while the production of complex PP parts by classical methods (turning and milling) requires significant costs and bulky equipment. For chemistry purposes, 3D printing allows for the design of reactors and devices to improve reaction efficiency [67][68][69][70][71][72][73].…”

Section: Introductionmentioning

confidence: 99%

3D Printing to Increase the Flexibility of the Chemical Synthesis of Biologically Active Molecules: Design of On-Demand Gas Generation Reactors

Erokhin

Gordeev

Samoylenko

et al. 2021

IJMS

View full text Add to dashboard Cite

The development of new drugs is accelerated by rapid access to functionalized and D-labeled molecules with improved activity and pharmacokinetic profiles. Diverse synthetic procedures often involve the usage of gaseous reagents, which can be a difficult task due to the requirement of a dedicated laboratory setup. Here, we developed a special reactor for the on-demand production of gases actively utilized in organic synthesis (C2H2, H2, C2D2, D2, and CO2) that completely eliminates the need for high-pressure equipment and allows for integrating gas generation into advanced laboratory practice. The reactor was developed by computer-aided design and manufactured using a conventional 3D printer with polypropylene and nylon filled with carbon fibers as materials. The implementation of the reactor was demonstrated in representative reactions with acetylene, such as atom-economic nucleophilic addition (conversions of 19–99%) and nickel-catalyzed S-functionalization (yields 74–99%). One of the most important advantages of the reactor is the ability to generate deuterated acetylene (C2D2) and deuterium gas (D2), which was used for highly significant, atom-economic and cost-efficient deuterium labeling of S,O-vinyl derivatives (yield 68–94%). Successful examples of their use in organic synthesis are provided to synthesize building blocks of heteroatom-functionalized and D-labeled biologically active organic molecules.

show abstract

Total protein assay by PCA-based RGB-spectrum conversion methods with smartphone-acquired digital images

2022

View full text Add to dashboard Cite

Development of an on-chip sample injection system with a 6-port valve incorporated in a microchip

Abstract: We demonstrate on-chip sample injection using a 6-port valve incorporated in a microchip.

Cited by 6 publications

References 43 publications

Configurable 3D Printed Microfluidic Multiport Valves with Axial Compression

Configurable 3D Printed Microfluidic Multiport Valves with Axial Compression

3D Printing to Increase the Flexibility of the Chemical Synthesis of Biologically Active Molecules: Design of On-Demand Gas Generation Reactors

Total protein assay by PCA-based RGB-spectrum conversion methods with smartphone-acquired digital images

Contact Info

Product

Resources

About