Development of an Irradiated Rodent Model to Study Flap Revascularization

Angelos, Patrick C.; McCarn, Kate E.; Winn, Shelley R.; Ghanem, Tamer; Kaurin, Darryl S.; Holland, John M.; Wax, Mark K.

doi:10.1001/archfacial.2010.16

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…VEGF-A is the most important VEGF known to regulate vascular permeability. 29 It can induce the proliferation and migration of vascular endothelial cells, promote the division and proliferation of vascular endothelial cells, and play an essential role in wound healing. 30 The results showed that VEGF-A levels in the E-dress group were significantly higher than in the other two groups, ∼2.1 times those of the AM group and 4 times those of the control group (Figure 3f).…”

Section: Self-powered E-dress For In Vitro Applicationsmentioning

confidence: 99%

Combined Amniotic Membrane and Self-Powered Electrical Stimulator Bioelectronic Dress Promotes Wound Healing

Wang,

Wu,

Xiao

et al. 2024

ACS Appl. Mater. Interfaces

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Human amniotic membranes (hAMs) are widely used as wound management biomaterials, especially as grafts for corneal reconstruction due to the structure of the extracellular matrix and excellent biological properties. However, their fragile nature and rapid degradation rate hinder widespread clinical use. In this work, we engineered a novel self-powered electronic dress (E-dress), combining the beneficial properties of an amniotic membrane and a flexible electrical electrode to enhance wound healing. The E-dress displayed a sustained discharge capacity, leading to increased epidermal growth factor (EGF) release from amniotic mesenchymal interstitial stem cells. Live/dead staining, CCK-8, and scratch-wound-closure assays were performed in vitro. Compared with amniotic membrane treatment alone, the E-dress promoted cell proliferation and migration of mouse fibroblast cells and lower cytotoxicity. In a mouse full-skin defect model, the E-dress achieved significantly accelerated wound closure. Histological analysis revealed that E-dress treatment promoted epithelialization and neovascularization in mouse skin. The E-dress exhibited a desirable flexibility that aligned with tissue organization and displayed maximum bioactivity within a short period to overcome rapid degradation, implying great potential for clinical applications.

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Section: Self-powered E-dress For In Vitro Applicationsmentioning

confidence: 99%

Combined Amniotic Membrane and Self-Powered Electrical Stimulator Bioelectronic Dress Promotes Wound Healing

Wang,

Wu,

Xiao

et al. 2024

ACS Appl. Mater. Interfaces

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“…In all of these studies, flaps are designed to demonstrate maximum necrosis in the control group with endpoints of improved flap survival over the control group. Multiple studies demonstrate necrosis in the control group [4][5][6][7][8] . This stands in opposition to the primary goal of clinical flap design, which is to ensure 100% flap survival without necrosis.…”

Section: Introductionmentioning

confidence: 99%

Novel Irradiated Axial Rotational Flap Model in the Rodent

Luginbuhl

Modest

Yan

et al. 2013

JAMA Facial Plast Surg

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Part of the Otolaryngology Commons This Article is brought to you for free and open access by the Jefferson Digital Commons. The Jefferson Digital Commons is a service of Thomas Jefferson University's Center for Teaching and Learning (CTL). The Commons is a showcase for Jefferson books and journals, peer-reviewed scholarly publications, unique historical collections from the University archives, and teaching tools. The Jefferson Digital Commons allows researchers and interested readers anywhere in the world to learn about and keep up to date with Jefferson scholarship. This article has been accepted for inclusion in

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Radiation and Microcirculation Models

Ayhan

Bulam

2014

Plastic and Reconstructive Surgery

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Development of an Irradiated Rodent Model to Study Flap Revascularization

Cited by 5 publications

References 14 publications

Combined Amniotic Membrane and Self-Powered Electrical Stimulator Bioelectronic Dress Promotes Wound Healing

Combined Amniotic Membrane and Self-Powered Electrical Stimulator Bioelectronic Dress Promotes Wound Healing

Novel Irradiated Axial Rotational Flap Model in the Rodent

Radiation and Microcirculation Models

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