Development of an Ion Chromatographic Method for Determination of Inorganic Cations in Seawater Used in the OTC Pharmaceutical Industry

Bolanča, Tomislav; Cerjan‐Stefanović, Štefica; Regelja, Melita; Štanfel, Danijela

doi:10.1081/jlc-200041309

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Several examples of application of IC in the analysis of pharmaceuticals can be found in the recent scientific literature [1][2][3][4][5][6]. A large number of IC col-*Address correspondence to this author at the Omega Laboratory, 11177 Hamon, Montréal, Québec, H3M 3E4, Canada; Tel: 1-514-335-0310, ext.…”

Section: Ion Chromatography With Suppressed Conductivity Detectionmentioning

confidence: 98%

Analytical Methods for Determination of Counter-ions in Pharmaceutical Salts

Rocheleau¹

2008

CPA

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Inorganic ions as well as organic acids or bases are frequently employed as counter-ions of ionizable drug substances. Therefore, analytical methods are required to confirm production of the correct salt form and to quantify the level of the counter-ion present in each batch of drug substances manufactured. Several options exist for determination of counter-ions in pharmaceutical salts and will be discussed in this review. Ion chromatography (IC) with conductivity detection is probably the most frequently employed method for ion determination. Other techniques such as capillary electrophoresis (CE) represent an alternative to IC for determination of counter-ions in pharmaceutical salts. Due to the lack of chromophores, detection of small ions in CE is typically performed using indirect UV detection. Hydrophilic interaction chromatography (HILIC) with evaporative light-scattering (ELSD) or refractive index detection can also be used for determination of non-UV absorbing ions. Each technique will be described and their advantages highlighted. Current and future trends in measuring counter-ions in pharmaceutical salts will also be discussed.

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Section: Ion Chromatography With Suppressed Conductivity Detectionmentioning

confidence: 98%

Analytical Methods for Determination of Counter-ions in Pharmaceutical Salts

Rocheleau¹

2008

CPA

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“…Установлено наличие в морской воде анионов: NO 2 -, NO 3 -, Br -, I -, Cl -, SO 4 2-, F -, HPO 4 2-, HCO 3 -, CO 3 2-, IO 3 -, катионов: Ca 2+ , K + , Mg 2+ , Na + , Pb 2+ , Mn 2+ , Mn 3+ . Кроме того, найдены элементы: Li, Sr, Co, Cd, Cu, Fe, Zn, As, Sb, Se, Cr, Pb, Ni, Tl, U, лантаноиды (La, Lu, Ce, Sm, Eu, Yb) [8,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. На рисунке 3 представлены сравнительные данные по количественному ионному составу воды 10 морей [12].…”

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Sea Water-Based Medicines: Manufacturing Technology and Standardisation

Терёшина¹,

Лякина²,

Наумова³

2020

Vedomosti Nauchnogo tsentra ekspertizy sredstv meditsinskogo pr

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Sea water and sea salt obtained from it are widely used as substances in the production of medicinal products. Complex chemical composition of sea water which contains various salts, calls for the development of a common quality standard for sea water-based medicines. The aim of the study was to analyse and summarise available data on the sources of sea water-based medicines, and on the current test methods, as well as to develop a unified approach to quality control. The paper summarises information on the use of sea water for medical purposes. It presents comparative data on the chemical composition of sea water obtained from different sources, manufacturing technologies of sea water-based medicines, and composition of medicines produced from sea water or sea salt. The paper summarises data on the use of sea water for the production of various dosage forms: drops, sprays, aerosols. The study revealed qualitative and quantitative differences in the content of major cations and anions in drug products. The authors analysed the use of various chemical and physico-chemical test methods for qualitative and quantitative characterisation of medicines. It was concluded that there is a need to harmonise quality control methods for sea water-based medicines.

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Environmental Applications of Ion Chromatography in Eastern and Central Europe

Michalski¹

2010

Journal of Chromatographic Science

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Environmental analytics is one of the most important applications of ion chromatography. It includes determination of ions in water and wastewater as well as in gaseous and solid ones. Nowadays, ion chromatography has almost completely displaced the classical methods of ion determination in these areas. In spite of the fact that the ion chromatography has been officially present in the scientific world for 36 years, its role and popularity is highly diversified in various countries and regions of the world. In highly industrialized countries, it has been a reference method of water and wastewater analysis for years. In other parts of the world, it is not used and appreciated sufficiently despite its undeniable advantages. The following paper is a short overview of the most highly cited scientific and research institutions that conduct research in terms of environmental applications of ion chromatography in Eastern and Central Europe. Furthermore, the paper presents a list of a number of scientific papers referring to the discussed area, published in the years 1996-2009 in some of the most highly cited international scientific journals, and concerning publications of scientists from Eastern and Central Europe seen against the background of Europe and the world.

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Development of an Ion Chromatographic Method for Determination of Inorganic Cations in Seawater Used in the OTC Pharmaceutical Industry

Cited by 3 publications

References 17 publications

Analytical Methods for Determination of Counter-ions in Pharmaceutical Salts

Analytical Methods for Determination of Counter-ions in Pharmaceutical Salts

Sea Water-Based Medicines: Manufacturing Technology and Standardisation

Environmental Applications of Ion Chromatography in Eastern and Central Europe

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