Development of an intelligent heterojunction fenton catalyst for chemodynamic/starvation synergistic cancer therapy

Ni, Weishu; Jiang, Ke; Ke, Qiaomei; Su, Jia; Cao, Xiaojian; Zhang, Ling; Li, Chunxia

doi:10.1016/j.jmst.2022.10.001

Cited by 21 publications

(15 citation statements)

References 28 publications

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“…Since the metal-containing compounds possess promising anticancer properties [ 25 , 26 , 27 , 28 ], we established the cytotoxic effects of the Cu1 – Cu5 thiourea complexes. To determine the potential cytotoxicity of new compounds, the MTT assay was used.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Structural Characterization and Biological Activity Evaluation of Novel Cu(II) Complexes with 3-(trifluoromethyl)phenylthiourea Derivatives

Drzewiecka-Antonik

Struga

Głogowska³

et al. 2022

IJMS

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Copper complexes with 1,3-disubstituted thiourea derivatives, all containing 3-(trifluoromethyl)phenyl tail and 1-alkyl/halogen-phenyl substituent, were synthesized. The experimental spectroscopic studies and theoretical calculation revealed that two ligands coordinate to Cu(II) in a bidentate fashion via thiocarbonyl S and deprotonated N atoms of thiourea moiety. Such monomers are characteristic of alkylphenylthiourea complexes, whereas the formation of a sandwich-type dimer is observed for halogeno derivatives. For the first time, the structural identifications of CuN2S2-based complexes using experimental and theoretical X-ray absorption near edge structure are demonstrated. The dimeric halogeno derivatives showed higher antimicrobial activity in comparison with alkylphenylthiourea complexes. The Cu(II) complex of 1-(4-chloro-3-nitrophenyl)-3-[3-(trifluoromethyl)phenyl]thiourea was active against 19 strains of methicillin-resistant Staphylococci (MIC = 2 µg/mL). This derivative acted as a dual inhibitor of DNA gyrase and topoisomerase IV isolated from Staphylococcus aureus. Additionally, complexes of halogenphenylthiourea strongly inhibited the growth of mycobacteria isolated from tuberculosis patients, even fourfold stronger than the reference isoniazid. The complexes exerted weak to moderate antitumor activity (towards SW480, SW620, and PC3) being non-toxic towards normal HaCaT cells.

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Section: Resultsmentioning

confidence: 99%

Synthesis, Structural Characterization and Biological Activity Evaluation of Novel Cu(II) Complexes with 3-(trifluoromethyl)phenylthiourea Derivatives

Drzewiecka-Antonik

Struga

Głogowska³

et al. 2022

IJMS

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“…Based on this, we have successfully fabricated a Fe 3 O 4 @MIL-100 heterojunction by layering MIL-100 onto the surface of Fe 3 O 4 nanoparticles. [56] Approximately 6.1 wt% of GOx was encapsulated into the pore space of MIL-100 by Figure 2. Schematic synthesis of TGZ@eM and its anti-tumor mechanism.…”

Section: Encapsulation Gox Through Physical Adsorption Methodsmentioning

confidence: 99%

“…During its enzymic catalytic reaction, GOx produces two products: H 2 O 2 , which can generate reactive oxygen species (ROS) such as ⋅OH, 1 O 2 , and O 2 − , and gluconic acid, which increases the acidity of the tumor microenvironment. Based on this, we have successfully fabricated a Fe 3 O 4 @MIL‐100 heterojunction by layering MIL‐100 onto the surface of Fe 3 O 4 nanoparticles [56] . Approximately 6.1 wt% of GOx was encapsulated into the pore space of MIL‐100 by physical adsorption strategy to obtain Fe 3 O 4 @MIL‐100@GOx (FMG).…”

Section: Gox@mofsmentioning

confidence: 99%

Recent advancements in combining MOFs and natural compounds for cancer therapy

Chen

Zhang

Jiang

2023

Zeitschrift anorg allge chemie

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In addition to drugs, natural compounds such as functional food factors have demonstrated great potential for cancer therapy due to their low cost, mild side effects, and common raw materials. However, their short half‐life period, easy decomposition, and lack of targeting severely limit their further development. Metal‐organic frameworks (MOFs) are a new type of porous crystalline materials that are created by combining metal clusters and organic linkers. MOFs have enormous applications, particularly in the biomedical field, due to their ability for pre‐functional design and post‐functional modification. In this mini‐review, we summarize recent research progress on combining MOFs with natural compounds for anti‐cancer performance, which will provide new insights for future research in the biomedical field.

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“…Chemodynamic therapy (CDT), a new therapeutic, is described as the generation of cytotoxic • OH at tumor locations via a Fenton or Fenton-like reaction [ 131 , 132 ]. Because CDT relies on the Fenton-type process, which primarily catalyzes endogenous hydrogen peroxide (H 2 O 2 ) to produce • OH, the low H 2 O 2 level in solid tumors will limit its usefulness.…”

Section: Applications Of Mof Nanomaterials In Targeting Cancer Therapymentioning

confidence: 99%

Utilization of Functionalized Metal–Organic Framework Nanoparticle as Targeted Drug Delivery System for Cancer Therapy

Tran

Doan

et al. 2023

Pharmaceutics

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Cancer is a multifaceted disease that results from the complex interaction between genetic and environmental factors. Cancer is a mortal disease with the biggest clinical, societal, and economic burden. Research on better methods of the detection, diagnosis, and treatment of cancer is crucial. Recent advancements in material science have led to the development of metal–organic frameworks, also known as MOFs. MOFs have recently been established as promising and adaptable delivery platforms and target vehicles for cancer therapy. These MOFs have been constructed in a fashion that offers them the capability of drug release that is stimuli-responsive. This feature has the potential to be exploited for cancer therapy that is externally led. This review presents an in-depth summary of the research that has been conducted to date in the field of MOF-based nanoplatforms for cancer therapeutics.

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Development of an intelligent heterojunction fenton catalyst for chemodynamic/starvation synergistic cancer therapy

Cited by 21 publications

References 28 publications

Synthesis, Structural Characterization and Biological Activity Evaluation of Novel Cu(II) Complexes with 3-(trifluoromethyl)phenylthiourea Derivatives

Synthesis, Structural Characterization and Biological Activity Evaluation of Novel Cu(II) Complexes with 3-(trifluoromethyl)phenylthiourea Derivatives

Recent advancements in combining MOFs and natural compounds for cancer therapy

Utilization of Functionalized Metal–Organic Framework Nanoparticle as Targeted Drug Delivery System for Cancer Therapy

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