Development of an Experimental Setup for Real-Time In-Line Dissolved Ozone Measurement for Medical Therapy

Abstract

Ozone therapy is established in clinical applications since many decades, such as treatment of infections or herniated discs. However, in-line monitoring of ozone concentrations is challenging and therefore not performed by default. We developed an experimental setup to measure the inline ozone concentration in water in real-time with a spectroscopic sensor. Thereby, the experimental setup enables the calibration and evaluation of newly evolved ozone sensors. The results for ozone concentration measurement with the spectroscopic sensor and the colorimetric photometer show a very good correlation. Furthermore, the ozone decay curves measured with our experimental setup highly correlate with those of previous research.

Systematic assessment of the biocompatibility of materials for inkjet-printed ozone sensors for medical therapy

“…For the measurement of the dissolved ozone concentration, the following measurement principles are suitable: amperometric, impedimetric with MOS or CNTs, absorption based, and photoluminescence. With regard to the concentration, a measurement has to be possible for dissolved ozone concentrations up to 70 µg ml −1 [6]. According to table 1 most of the sensors can be operated at RT.…”

“…For the membrane and substrate PDMS (Sylgard 184 Elastomer Kit by Dow Corning, USA) is applied. The most important properties for processing the inks with an inkjet-printer are shown in table 6. Solvents, solid fraction, and NPs sizes influence the properties of the printed layers such as homogeneity, conductivity, porosity, and coffee ring effect [114].…”

“…The sensor has to be produced under sterile conditions or sterilized after the production to be free of infectious germs [4]. Previous work investigated applications of ozone sensors for different medical applications and the current approaches of inkjet-printed ozone sensors and developed an experimental setup for novel ozone sensors [5,6]. In order to further expand this research, we examined the biocompatibility of the materials, utilized for two exemplary amperometric and impedimetric ozone sensor approaches.…”