Development of an Electrohydraulic Total Artificial Heart System

Tatsumi, Eisuke; Taenaka, Yoshiyuki; Masuzawa, Toru; Choi, Won Hoon; Toda, Köichi; Miyazaki, Kôji; Nakatani, Takeshi; Yagura, Akihiko; Baba, Yoshiyasu; Eya, Kazuhiro; Wakisaka, Yoshinari; Tominaga, Motomu E.; Takano, Hisateru; Uyama, Chikao; Koshiji, Kohji; Nomura, T.; Yasaki, T.; Shu, Eimei; Utsunomiya, Tohru; Ohno, Takashi; Fukui, Yasuhiro

doi:10.1007/978-4-431-67020-9_11

Cited by 2 publications

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References 6 publications

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“…The electronics unit is composed of internal and external controller subunits, transcutaneous energy transfer and optical telemetry subunits, and internal and external battery subunits. A report of the present development status and a detailed description of the electronics unit have been published elsewhere ( 5–7).…”

Section: Methodsmentioning

confidence: 99%

In Vivo Evaluation of the National Cardiovascular Center Electrohydraulic Total Artificial Heart

et al. 1999

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We have been developing an electrohydraulic total artificial heart system. The system comprises an intrathoracic pumping unit composed of diaphragm type ellipsoidal blood pumps and an energy converter in addition to an electronics unit. The in vivo performance of the pumping unit was evaluated in a series of animal implantations with 3 calves weighing 62-85 kg. An interatrial shunt 4.5 mm in diameter was made in the atrial septum to compensate left-right imbalance. Two calves died early postoperatively, one of external controller power failure and the other of interatrial shunt stenosis due to thrombus formation. One calf, however, survived over 10 days under stable circulatory conditions. No abnormality was found in the oxygen metabolic condition or in major organ functions. The generation and dissipation of heat from the device was acceptable. This animal died of device malfunction caused by energy converter bearing breakdown. The device demonstrated a good anatomic fit without compromising the great vessels and adjacent tissues. It is concluded that the pumping unit has a sufficient in vivo basic performance although appropriate countermeasures are to be implemented against the detected problems concerning mechanical durability and interatrial shunt patency.

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Section: Methodsmentioning

confidence: 99%

In Vivo Evaluation of the National Cardiovascular Center Electrohydraulic Total Artificial Heart

et al. 1999

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Current status of development and in vivo evaluation of the National Cardiovascular Center electrohydraulic total artificial heart system

et al. 2000

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We have been developing an electrohydraulic total artificial heart system. The system has a pumping unit, consisting of diaphragm-type blood pumps and an energy converter, and an electronics unit, consisting of an internal controller, an internal battery, and transcutaneous energy transfer and optical telemetry subunits. The energy converter, designed to be placed outside the pericardial space, reciprocates and delivers hydraulic silicone oil to the alternate blood pumps through a pair of flexible oil conduits. The left-right output balance is achieved with an interatrial shunt made in the composite atrial cuff. In vivo performance of the pumping unit has been evaluated by chronic implantation of 16 calves weighing 54-88kg. Five calves survived for more than a week, and the longest-surviving animal lived for over 12 weeks until its accidental death. In this animal, a cardiac output of 6-8 l/rain was maintained by the device with power consumption of 13.5 _+ 0.9W and 9%-11% efficiency. The left and right atrial pressures were 16 _+ 4 and 14 _+ 4mmHg, respectively, and the left-right output difference was adequately balanced with the intera- K. Tsukahara 9 K. Tsuchimoto -H. Wakui Aisin Cosmos R&D, Kariya, Japan trial shunt. The mixed venous oxygen saturation was 65 • 6% and the serum lactate level was 5 _+ 1 mg/dl, representing favorable oxygen metabolic conditions. The temperatures of the energy converter and the blood pump surfaces were 39.4 -+ 0.7 ~ and 38.8 + 1.5~ respectively, indicating that heat generation and dissipation were acceptable. The serum and tissue silicon levels were within normal (<1 ~g/ml or

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Development of an Electrohydraulic Total Artificial Heart System

Cited by 2 publications

References 6 publications

In Vivo Evaluation of the National Cardiovascular Center Electrohydraulic Total Artificial Heart

In Vivo Evaluation of the National Cardiovascular Center Electrohydraulic Total Artificial Heart

Current status of development and in vivo evaluation of the National Cardiovascular Center electrohydraulic total artificial heart system

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