Development of an Artificial Myocardium using a Covalent Shape-memory Alloy Fiber and its Cardiovascular Diagnostic Response

Shiraishi, Yasuyuki; Yambe, Tomoyuki; Sekine, Keitaro; Masumoto, Noriyasu; Nagatoshi, Jun; Itoh, S.; Saijo, Yoshifumi; Wang, Q.; Liu, H.; Nitta, S.; Konno, Satoshi; Ogawa, Daisuke; Olegario, P.; Yoshizawa, Makoto; Sato, F.; Park, Y.; Uematsu, Miyuki; Higa, Masaru; Hori, Yuki; Fujimoto, Tetsuo; Tabayashi, Koichi; Sasada, Hiroshi; Umezu, Mitsuo; Homma, Dai

doi:10.1109/iembs.2005.1616431

Cited by 21 publications

(14 citation statements)

References 11 publications

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“…The pump produced a maximal work of 16 Â 10 À3 J. Maximal volume pumped was 492 ml/min. Mean volume pumped was 120 AE 10 ml/min with a pre-load of 15 cmH 2 O and maximal after-load of 16 …”

Section: Resultsmentioning

confidence: 99%

“…More recently, Yambe and co-workers [15,16] have developed a nitinol-based artificial muscle to be used as VAD that can be activated at a frequency of 40 times per minute, which represents an important improvement with respect to first experimental data. Today's nitinol alloys provide a billion working cycles in bench models and that should correspond to more than 10 years lifetime.…”

Section: Discussionmentioning

confidence: 98%

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Atria assist device to restore transport function of fibrillating atrium☆

Tozzi¹,

Hayoz

Thévenaz

et al. 2008

European Journal of Cardio-Thoracic Surgery

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Atria assist device to restore transport function of fibrillating atrium☆

Tozzi¹,

Hayoz

Thévenaz

et al. 2008

European Journal of Cardio-Thoracic Surgery

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“…How- ever, contraction cycle, material fatigue, heating, and energy supply were major limitations, and this project never went further. More recently, Yambe and coworkers 5,6 have developed a nitinol based artificial muscle to be used as a VAD that represents a significant improvement with respect to Sawyer's model. We learned a lot from those past experiences and designed a pulsatile pump that overcame the historical limitations of nitnol wire when used as an actuator.…”

Section: Discussionmentioning

confidence: 97%

Artificial Muscles to Restore Transport Function of Diseased Atria

Tozzi¹,

Hayoz²,

Thévenaz³

et al. 2008

ASAIO Journal

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Surgical treatment of persistent atrial fibrillation often fails to restore the transport function of the atrium. This study first introduces the concept of an atrial assist device to restore the pump function of the atrium. A micro motorless pump based on artificial muscle technology, is positioned on the external surface of the atrium to compress it and restore its muscular activity. A bench model reproduces the function of fibrillating atrium to assess the circulatory support that this pump can provide. The Atripump is a dome shape silicone coated nitinol actuator mounted on a plastic ring. A pacemaker-like control unit drives the actuator, which compresses the atrium, providing the mechanical support to the blood circulation. The bench model consists of an open circuit made of latex bladder 60 mm in diameter filled with water. The Atripump is placed on the outer surface of the bladder. Pressure, volume, and temperature changes were recorded. The contraction rate was 1 Hz with power supply of 12 V, 400 mA for 200 milliseconds. Preload ranged from 15 to 21 cm H20. The pump produced a maximal work of 16 x 10(-3) J. Maximal volume pumped was 492 ml/min. This artificial muscle pump is compact, and reproduces the hemodynamic performances of normal atrium.

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“…The authors assumed that the essence of the pathophysiological development of severe heart failure was in the decrease in the cardiac contractility. Then an artificial myocardium has been developed using a covalent nano-tech shape memory alloy fibre, which is capable of assisting natural cardiac contraction from out-side of the ventricular wall as shown in Figure 1 [3]. The purpose of this study was to develop a sophisticated artificial myocardium unit, and also to have examined the hemodynamic effects of the myocardial assist system on cardiac function.…”

Section: Introductionmentioning

confidence: 99%

Morphological Approach for the Functional Improvement of an Artificial Myocardial Assist Device using Shape Memory Alloy Fibres

Shiraishi

Yambe

Saijo

et al. 2007

2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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The authors have been developing a mechano-electric artificial myocardial assist system (artificial myocardium) which is capable of supporting natural contractile functions from the outside of the ventricle without blood contacting surface. In this study, a nano-tech covalent type shape memory alloy fibre (Biometal, Toki Corp, Japan) was employed and the parallel-link structured myocardial assist device was developed. And basic characteristics of the system were examined in a mechanical circulatory system as well as in animal experiments using goats. The contractile functions were evaluated with the mock circulatory system that simulated systemic circulation with a silicone left ventricular model and an aortic afterload. Hemodynamic performance was also examined in goats. Prior to the measurement, the artificial myocardial assist device was installed into the goat's thoracic cavity and attached onto the ventricular wall. As a result, the system could be installed successfully without severe complications related to the heating, and the aortic flow rate was increased by 15% and the systolic left ventricular pressure was elevated by 7% under the cardiac output condition of 3L/min in a goat. And those values were elevated by the improvement of the design which was capable of the natural morphological myocardial tissue streamlines. Therefore it was indicated that the effective assistance might be achieved by the contraction by the newly-designed artificial myocardial assist system using Biometal. Moreover it was suggested that the assistance gain might be obtained by the optimised configuration design along with the natural anatomical myocardial stream line.

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Development of an Artificial Myocardium using a Covalent Shape-memory Alloy Fiber and its Cardiovascular Diagnostic Response

Cited by 21 publications

References 11 publications

Atria assist device to restore transport function of fibrillating atrium☆

Atria assist device to restore transport function of fibrillating atrium☆

Artificial Muscles to Restore Transport Function of Diseased Atria

Morphological Approach for the Functional Improvement of an Artificial Myocardial Assist Device using Shape Memory Alloy Fibres

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