Development of an Animal Model for Wound Healing in Chronic Rhinosinusitis

Tansavatdi, Kristina; McGill, Lawrence D.; Riggs, Sterling; Orlandi, Richard R.

doi:10.1001/archoto.2010.136

Cited by 12 publications

(15 citation statements)

References 16 publications

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“…Patients with serum and tissue eosinophilia often require systemic steroids and have significantly higher recurrence and revision rates [15,[21][22][23]. In a previous study of the steroid-eluting implant, revision ESS was indicated in 2.2% (2/90) of cases with use of the Propel stent, which is consistent with the revision rate (1.5%) in the present study [6].…”

Section: Discussionsupporting

confidence: 87%

Eosinophilia and Quality of Life in Patients Receiving a Bioabsorbable Steroid-Eluting Implant during Endoscopic Sinus Surgery

Pou

Riley

Tipirneni³

et al. 2017

Sinusitis

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Abstract:Introduction: Bioabsorbable steroid-eluting implants are available as an adjunct for endoscopic sinus surgery (ESS) in the treatment of chronic rhinosinusitis (CRS). It is unclear which patients are most likely to benefit from this technology. We sought to determine if the severity of preoperative sinonasal inflammation influences the postoperative changes in patient-reported quality of life (QOL) and endoscopic appearance following ESS with implant placement; Methods: Consecutive adult patients undergoing ESS for CRS with ethmoidectomy and placement of a steroid-eluting implant over an 18-month period were prospectively included for study. Pre-operative sinus computed tomography (CT) opacification was evaluated using the Lund-Mackay score (LMS). Sinonasal Outcome Test (SNOT-22) scores and Lund-Kennedy endoscopic scores (LKES) for each patient were collected preoperatively and at three-and six-month intervals postoperatively. Serum eosinophilia (>6.0% on peripheral smear) and sinus tissue eosinophilia were recorded; Results: One hundred and thirty-six patients were included for analysis. Of these, 36.7% had polyposis, 15.4% had serum eosinophilia and 64.0% had tissue eosinophilia. The mean (standard deviation) SNOT-22 score was 45.5 (19.4) preoperatively, which improved postoperatively to 18.8 (14.1) at three months (p < 0.001) and 16.5 (14.0) at six months (p < 0.001). Similar results were found when stratified by the presence of polyposis, serum eosinophilia, tissue eosinophilia or high-grade CT findings (LMS > 6). Higher baseline LKES was observed for patients with eosinophilia or high-grade LMS, but these differences normalized at six months postoperatively; Conclusions: Patient-reported QOL and endoscopic appearance show improvement six months after placement of a steroid-eluting implant during ESS, irrespective of the presence of polyposis or eosinophilia.

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Section: Discussionsupporting

confidence: 87%

Eosinophilia and Quality of Life in Patients Receiving a Bioabsorbable Steroid-Eluting Implant during Endoscopic Sinus Surgery

Pou

Riley

Tipirneni³

et al. 2017

Sinusitis

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“…However, Lindsay et al selected Af as a study antigen because Af has been implicated in the pathophysiology of chronic hyperplastic eosinophilic rhinosinusitis and in allergic fungal sinusitis. Subsequently, Tansavatdi et al developed a murine model for wound healing in CRS using Af extracts . This model mimicked the sinus wound healing process rather than the pathogenesis of sinusitis.…”

Section: Resultsmentioning

confidence: 99%

Animal Models in CRS and Pathophysiologic Insights Gained: A Systematic Review

Shin

2016

Laryngoscope Investigative Otolaryngology

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ObjectiveChronic rhinosinusitis (CRS) is a multifactorial inflammatory disease. In particular, CRS with eosinophilic features and/or nasal polyps (NPs) is often recalcitrant to current treatment; thus, appropriate animal models are mandatory to elucidate the pathogenesis of CRS and develop novel and efficient treatment modalities. The author reviewed the recently proposed animal models in CRS and discussed the pathophysiologic insights gained.Data Sources: Articles in the English language referenced in MEDLINE/PubMed from the year 2006 onward (for last 10 years).Review Methods: Review of the literature regarding animal models and related pathologic insights in CRS.ResultsMouse, rabbit, and sheep models of CRS have been used for studying the pathogenesis of CRS. Most of researchers adopted animal models of CRS to prove any molecular mechanisms or therapeutic efficacy. In vitro or human findings and related hypothesis were evaluated in vivo using these models. In addition, novel therapeutic candidates for CRS with or without NP have been applied to animal models.ConclusionAnimal models have elicited insights into the pathogenesis of CRS and also have been useful in testing new treatment modalities. Although there are still clear limitations in the animal studies, newly proposed or revised animal models would be helpful to understand the exact pathophysiology of CRS

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“…They also compared it to wounding the non‐inflamed sinus mucosa in normal mice. As expected, inflamed mucosa showed a stronger response to the needle trauma, therefore, had a higher potential for scarring during wound healing . An allergic sinusitis model in mice was established by Kim et al They induced allergic inflammation in mice with ovalbumin (OVA), an allergenic protein found in chicken egg whites.…”

Section: Introductionmentioning

confidence: 91%

Models for the study of nasal and sinus physiology in health and disease: A review of the literature

Al-Sayed

Agu

Massoud

2017

Laryngoscope Investig Oto

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ObjectiveChronic sinusitis is a very common yet poorly understood medical condition with significant morbidity. Hence, it remains an entity that is difficult to treat with unsatisfactory outcomes of current management options. This necessitates research into the etiology and pathophysiology of the condition to enhance our knowledge and the therapeutic options. Unfortunately, this kind of research is not always feasible on human subjects due to practical and ethical limitations. Therefore, an alternative model that simulates the disease had to be found in order to overcome these limitations. These models could either be in vivo or in vitro. The aim of our review is to summarize the research findings and key discoveries of both in vivo and in vitro models of chronic sinusitis that have enhanced our understanding of the condition today and have paved the way for the future research of tomorrow. Data Sources: PubMed literature review.MethodsA review of the literature was conducted to identify the main successful in vivo and in vitro models for chronic sinusitis.ResultsCreating a successful model for chronic sinusitis is no easy task. Over the years, both in vivo animal models and in vitro tissue culture models were proposed, with each model having its accolades and pitfalls, with the ideal model remaining elusive to this day. However, advancing three‐dimensional cell culturing techniques seems to be a promising new way to find a more accurate model.ConclusionNone of the current models is perfect for a thorough study of chronic sinusitis. However, three‐dimensional cell cultures have the potential to bridge the gap between in vivo and in vitro studies.Level of EvidenceNA

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Development of an Animal Model for Wound Healing in Chronic Rhinosinusitis

Cited by 12 publications

References 16 publications

Eosinophilia and Quality of Life in Patients Receiving a Bioabsorbable Steroid-Eluting Implant during Endoscopic Sinus Surgery

Eosinophilia and Quality of Life in Patients Receiving a Bioabsorbable Steroid-Eluting Implant during Endoscopic Sinus Surgery

Animal Models in CRS and Pathophysiologic Insights Gained: A Systematic Review

Models for the study of nasal and sinus physiology in health and disease: A review of the literature

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