Development of an analytical strategy based on LC–MS/MS for the measurement of different classes of pesticides and theirs metabolites in meconium: Application and characterisation of foetal exposure in France

Berton, Thierry; Mayhoub, Flora; Chardon, Karen; Duca, Radu Corneliu; Lestremau, François; Bach, Véronique; Tack, Karine

doi:10.1016/j.envres.2014.03.034

Cited by 55 publications

(43 citation statements)

References 59 publications

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“…Infertility has also been found among married male farm workers, and higher among farm workers' families (such as wives' experiencing stillbirths and abortions) than the normal population (Neghab et al, 2014). The same was established by Berton and colleagues on exposure of mothers, and that there was fetal exposure to organophosphate pesticides, pyrethroids, and carbamates (Berton et al, 2014). Prenatal exposures to organochlorine were also associated with lower birth weight (Guo et al, 2014).…”

Section: Discussionmentioning

confidence: 52%

Ergonomic and health assessment of farmers’ multi-pesticide exposure

Lu¹

2017

Ergonomics South Afr

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Objective. This was a cross-sectional study conducted among 534 farmers in the largest vegetable -producing area in the northern part of the Philippines. This study assessed the ergonomic risk factors, and occupational health and safety conditions of farmers' multi-pesticide exposures.Methods. Methods consisted of interviewer-guided survey questionnaires on pesticide use among farmers, agricultural safety risk factors associated with pesticide exposure and physical health assessments of farmers. The subjects were selected using multistage random sampling, yielding a total of 534 farmers.Results. The majority of the study population were males (53.3%), with a mean age of 47 years old. Occupational exposure accounted for major exposure (84.8%). Farmers often complained of a headache (69.4%) and dizziness (41.0%) after their exposure to pesticides. As for common respiratory symptoms, farmers often complained of coughing (39.4%), difficulty with breathing (15.6%), breathlessness (14.9%) and having pulmonary secretions (13.3%). Farmers reported pesticide spills on their body parts while spraying (79%), and 49 % complained of getting sick because of work. Of those who got ill, 69.8% did not receive any medical attention. Of the farmers, 40.9% were diagnosed with abnormal physical examination findings, and less than 10% had abnormal laboratory results. Conclusion.The results showed that farmers were exposed to pesticides while undertaking their agricultural work and that certain occupationally-related health symptoms manifested. This underscores the need to improve protection measures to reduce the exposure of the farmers to pesticides.

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Section: Discussionmentioning

confidence: 52%

Ergonomic and health assessment of farmers’ multi-pesticide exposure

Lu¹

2017

Ergonomics South Afr

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“…To determine a possible link with malformations, the target compounds of the PENEW project regrouped a large variety of pollutants within several families of pesticides, their metabolites, VOCs [14] and metabolites. Compared to a previous study carried out by our group where the analysis of certain micropollutants was performed on a C 18 column [12], the current list of compounds included additional pesticides (epoxiconazole, tebuconazole, 2, 4-D, etc.) and also, notably, substances with stronger polarity (glyphosate) or different polar functional groups (acid compounds with the metabolites of VOCs).…”

Section: Introductionmentioning

confidence: 99%

“…Meconium was already used to quantify fetal exposure to drugs and metabolites [7,8], alcohol metabolites [9,10] or pesticides [11,12] with the analysis performed by liquid chromatography coupled with tandem mass spectrometry LC/MS/MS. Usually these analytical methods were focused only on restricted classes of compounds and eventually their metabolites [8,9,13].…”

Section: Introductionmentioning

confidence: 99%

Development of liquid chromatography methods coupled to mass spectrometry for the analysis of substances with a wide variety of polarity in meconium

Meyer-Monath

Chatellier

Cabooter

et al. 2015

Talanta

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Meconium is the first fecal excretion of newborns. This complex accumulative matrix allows assessing the exposure of the fetus to xenobiotics during the last 6 months of pregnancy. To determine the eventual effect of fetal exposure to micropollutants in this matrix, robust and sensitive analytical methods must be developed. This article describes the method development of liquid chromatography methods coupled to triple quadrupole mass spectrometry for relevant pollutants. The 28 selected target compounds had different physico-chemical properties from very polar (glyphosate) to non-polar molecules (pyrethroids). Tests were performed with three different types of columns: reversed phase, ion exchange and HILIC. As a unique method could not be determined for the simultaneous analysis of all compounds, three columns were selected and suitable chromatographic methods were optimized. Similar results were noticed for the separation of the target compounds dissolved in either meconium extract or solvent for reversed phase and ion exchange columns. However, for HILIC, the matrix had a significant influence on the peak shape and robustness of the method. Finally, the analytical methods were applied to "real" meconium samples.

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“…With the development of mass spectrometry technology, hypersensitive tandem mass spectrometry further highlighted these advantages. The monitoring and content determination of pesticide residues were mainly carried out on tandem mass spectrometry in recent years [11][12][13][14][15][16]. The MS mode for quantitative analysis included multiple reaction monitoring (MRM) and selected ions monitoring (SIM).…”

Section: Introductionmentioning

confidence: 99%