This study proposes a cost‐effective, small‐size, and portable impedance analyzer using the AD5941 Analog Front End (AFE) that makes frequency sweep measurement for various applications. The design utilizes a microcontroller and an AD5941 circuit for impedance measurement. The AD541 is a high precision impedance converter system that consists of a 16‐bit, 1.6 MSPS, analog to digital converter (ADC), an integrated waveform generator, and a digital signal processing (DSP) block. The AD5941 has many advantages over the AD5933 which was used in numerous studies in the past decade. Also, the device implements the four‐wire impedance method which is an impedance measuring technique that reduces the effect of electrodes to achieve higher accuracy. A supporting Graphic User Interface (GUI) software is employed to control the Impedance Analyzer device and to visualize the measurement. This impedance analyzer achieves a frequency resolution of 0.015 Hz and can generate sinusoid up to 200 kHz. In frequency range from 10 kHz to 150 kHz, the device can measure impedance in the range of 10 Ω–100 kΩ with less than 4.3% of error in comparison with benchtop impedance analyzer, Microtest 6632. Moreover, our impedance measurement device has undergone testing involving human calf measurements and electrochemical quantification, particularly for estimating Sodium Chlorite. The experimental outcomes demonstrate that our design not only fulfills the criteria of an impedance analyzer device but also performs effectively across diverse applications. © 2024 Institute of Electrical Engineer of Japan and Wiley Periodicals LLC.