Development of Aloin Loaded PVA/CMC Hydrogel for Wound Healing

Abstract

The purpose of this study was to develop an aloin-loaded wound dressing with an enhanced healing effect. The cross-linked hydrogel films were prepared with poly(vinyl alcohol) (PVA) and carboxyl methyl cellulose (CMC) using a freeze-thawing (F-T) method. Their gel properties, release of drug, in vivo wound healing effect and histopathology were then evaluated. In the wound healing test, this aloin loaded PVA/CMC hydrogel showed faster healing of the wound made in rat dorsum than the aloin carbomer 934 gel or the control (carbomer 934 gel) due to phytochemical activity of aloin and moisture of CMC. In conclusion, the aloin-loaded wound dressing composed of 5% PVA, 5% CMC and 0.125% aloin is a potential wound dressing with enhanced wound healing effect.

Investigating the specific absorption rate and antimicrobial activity of Mn0.25Fe2.75O4/Ag ferrogel based on carboxymethyl cellulose/polyvinyl alcohol composite polymer

“…29 Furthermore, CMC/PVA hydrogels can be easily fabricated since it has excellent hydrophilicity. 30 Characterization of the Specific Absorption Rate (SAR) value of the CMC/PVA- Mn 0.25 Fe 2.75 O 4 /Ag ferrogel is the focus of this study.…”

Synthesis, Characterization and Swelling Properties of Chitosan/Poly(acrylic acid-co-crotonic acid) Semi-Interpenetrating Polymer Networks

“…Therefore, these hydrogels have important applications in the field of medicine, pharmacy, and biotechnology. [31][32][33][34][35][36] Semi-IPN hydrogels of chitosan have been investigated by researchers. For instance, semi-IPN hydrogels of chitosan with polyether, 37 poly(acrylic acid), 38 poly(ethylene glycol), 39 and poly(N-isopropylacrylamide) 40 have been reported.…”