Development of allergen-specific T-cell memory in atopic and normal children

Prescott, Susan L.; Macaubas, Claudia; Smallacombe, T.; Holt, Barbara J.; Sly, Peter D.; Holt, Patrick G.

doi:10.1016/s0140-6736(98)05104-6

Cited by 809 publications

(698 citation statements)

References 23 publications

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“…Further adjustment for the effect of maternal vitamin D and polyunsaturated fatty acids intake and stratification by parental allergies and month of birth of the child did not alter these results. Prenatal antioxidant exposures may program the child's susceptibility to allergic disorders already in utero (Prescott et al, 1999;Devereux, 2007). Our results did not confirm the protective effects that have been observed between the intake of vitamin E and zinc and the risk of asthma (Devereux et al, 2006).…”

Section: Discussioncontrasting

confidence: 97%

“…Childhood risk of allergies may already be influenced in utero by the antioxidants status of the mother during pregnancy (Prescott et al, 1999;Devereux, 2007). Some studies have reported a reduced risk of asthma and wheezing in the offspring with high maternal intake of vitamin E during pregnancy (Martindale et al, 2005;Devereux et al, 2006;Litonjua et al, 2006;Miyake et al, 2010a), whereas no association was observed regarding eczema (Devereux et al, 2006;Litonjua et al, 2006;Miyake et al, 2010b).…”

Section: Introductionmentioning

confidence: 99%

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Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring

et al. 2011

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Background/Objectives: The potential immune functions related to the damages induced by oxygen-free radicals suggest that antioxidants may have a role in the development of allergies. The objective was to investigate the association between maternal intake of antioxidants during pregnancy and the risk of asthma, rhinitis and eczema in 5-year-old children. Subjects/Methods: This study was on the basis of the Finnish Type 1 Diabetes Prediction and Prevention Nutrition Study, a population-based birth cohort study with 5-year follow-up. Complete information on maternal food frequency questionnaire data and ISAAC (International Study of Asthma and Allergies in Childhood)-based allergic outcomes were available for 2441 children. Cox proportional regression and logistic regression were used for the analyses. Results: Maternal intake of any of the antioxidants was not significantly associated with the risk of asthma, rhinitis or eczema in the offspring, except for dietary intake of magnesium, which was independently associated with protection against eczema (OR 0.78; 95% CI 0.62-0.97). Conclusion: Maternal intake of dietary magnesium during pregnancy may protect against the risk of eczema in the offspring. We did not confirm previous observations concerning other antioxidants. This may be due to the variable amount of antioxidant intake across studies and also indicative of the hypothesis that there may be a critical time window in pregnancy during which antioxidants might modify the risk of allergies in the offspring.

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Section: Discussioncontrasting

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring

et al. 2011

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“…Furthermore, evaluation by bronchial biopsy has shown that this drug decreases the number of eosinophils and EG2-positive cells in the airway mucosa, as well as inhibiting goblet cell hyperplasia (17,19). Infants with a family history of atopy and infants in whom atopic disease occurs soon after birth have been reported to show a shift of the Th1-Th2 cytokine balance towards Th2 dominance (20,21). Accordingly, the Th1-Th2 balance during the early postnatal period is believed to be a key factor in determining whether or not allergy develops.…”

Section: Th2 Cytokine Inhibitor: Suplatast Tosilatementioning

confidence: 99%

Suplatast Tosilate for Prophylaxis of Pediatric Atopy

Yoshihara¹,

Ono²,

Yamada³

et al. 2012

Atopic Dermatitis - Disease Etiology and Clinical Management

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“…develop atopy, these Th2-cytokine-mediated immune responses appear to be preserved in early periods of infancy (19,20) and may be perpetuated in those who will develop persistent atopic disease (21). On the contrary, a generalized immaturity or suppression of both Th1 and Th2 type immune responses may occur at birth in atopyprone babies (22), followed by a delayed maturation of the Th1 pathways leading to an enhanced release of Th2 cytokines which will perpetuate Th2-driven responses (19).…”

Section: Perinatal Influences On Ige-mediated Allergymentioning

confidence: 99%

“…On the contrary, a generalized immaturity or suppression of both Th1 and Th2 type immune responses may occur at birth in atopyprone babies (22), followed by a delayed maturation of the Th1 pathways leading to an enhanced release of Th2 cytokines which will perpetuate Th2-driven responses (19). Postnatal IFN-c upregulation is usually delayed until the age of 1 year and rises steadily thereafter (18).…”

Section: Perinatal Influences On Ige-mediated Allergymentioning

confidence: 99%

Epigenetic inheritance of fetal genes in allergic asthma

Bousquet

Jacot

Yssel

et al. 2004

Allergy

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Asthma has been associated with an exaggerated T‐helper type 2 (Th2) over Th1 responses to allergic and nonallergic stimuli, which leads to chronic airway inflammation and airway remodeling. In the present article, we propose that many of the genes involved in IgE synthesis and airways (re)modeling in asthma are persistent or reminiscent fetal genes which may not be silenced during early infancy (or late pregnancy). Genes of the embryologic differentiation of ectodermic and endodermic tissues may explain some of the patterns of airway remodeling in asthma. In utero programming leads to gene expression, the persistence of which may be associated with epigenetic inheritance phenomena induced by nonspecific environmental factors. Clear delineation of these issues may yield new information on the mechanisms of asthma and new targets for therapeutic intervention and primary prevention.

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Development of allergen-specific T-cell memory in atopic and normal children

Cited by 809 publications

References 23 publications

Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring

Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring

Suplatast Tosilate for Prophylaxis of Pediatric Atopy

Epigenetic inheritance of fetal genes in allergic asthma

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