Development of Agglomerated Crystals of Ascorbic Acid by the                    Spherical Crystallization Technique for Direct Tableting, and Evaluation of                    Their Compactibilities [Translated]&lt;sup&gt;†&lt;/sup&gt;

Kawashima, Yasunaru; Imai, Misato; Takeuchi, Hirofumi; Yamamoto, Hiromitsu; Kamiya, Kazunori

doi:10.14356/kona.2002028

Cited by 13 publications

(5 citation statements)

References 8 publications

(6 reference statements)

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“…This also supports the hypothesis that one microsphere was formed per liquid droplet. Various studies on particle formation in emulsion droplets in a liquid have been conducted (Mersmann, 1998;Kawashima et al, 2002;Yoshizawa, 2004). However, the particle formation mechanism in the proposed electrospray method is better equipped to create various particle structures than the particle formation mechanisms reported previously.…”

Section: Effect Of Plga Concentration On the Formation Of Plga Particlesmentioning

confidence: 99%

Biodegradable PLGA Microsphere Formation Mechanisms in Electrosprayed Liquid Droplets

Tanaka

Ochi

Sasai

et al. 2022

KONA

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Microspheres composed of poly (lactic-co-glycolic acid) (PLGA) were formed in liquid droplets using the electrospray technique. The structure of the microspheres was controlled by changing the electric voltage of the electrospray. PLGA microspheres with porous structures and micro-sized nanocomposite particles comprising PLGA nanosphere aggregates were formed at 5.0-7.0 kV and 2.5-3.5 kV, respectively. The structural change was related to the extent of evaporation of the solvent from the droplets during their flight. When the evaporation was completed in the relatively small droplets, the microspheres with porous structures were formed in the droplets. To study the mechanism, we observed the effects of the electric voltage of the electrospray, PLGA concentration, flight distance of the droplets, and molecular weight of PLGA on the structure of the PLGA particles. The novelty of this study is the analysis of the size and structure of the PLGA microparticles, which were controlled by the electrospray technique. Therefore, this research has important implications for the structural design and preparation of nanocomposite particles.

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Section: Effect Of Plga Concentration On the Formation Of Plga Particlesmentioning

confidence: 99%

Biodegradable PLGA Microsphere Formation Mechanisms in Electrosprayed Liquid Droplets

Tanaka

Ochi

Sasai

et al. 2022

KONA

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“…9. The precipitation of IMC dominantly occurred on the surface of NaCl from the kinetic crystallization parameters (Mersmann, 1998;Kawashima et al, 2002). NaCl crystals were first precipitated at the interface of 2-butanone and the aqueous solutions and agglomerated during the flow of the droplet.…”

Section: Synthesis Of Organic-inorganic Composite Particles By Using mentioning

confidence: 99%

Particle Preparation and Morphology Control with Mutual Diffusion Across Liquid-Liquid Interfaces

Kadota

Shirakawa

2021

KONA

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Advanced functional materials require sophisticated control of particle characteristics. The bottom-up process has been extensively used to produce functional materials for controlling the particle properties of composite particles. We propose crystallization at liquid-liquid interfaces as an advanced particle formation method. This review introduces crystallization at a liquid-liquid interface based on several case studies used in various applications. Conventional crystallization has been generally used to produce crystals and particles with homogeneous particle properties. Liquid-liquid interfacial crystallization makes it possible to create composite particles with hetero-phase structures and interfaces. Liquid-liquid interfacial crystallization with an inkjet technique can control the droplet size accurately, and the shape and particle size distribution are successfully controlled in inorganic-organic composite particles. In addition, we succeed in creating organic-organic composite particles using the interfacial crystallization by an ultrasonic spray nozzle. The coating efficiency of organic particles on the particles is enhanced using the ultrasonic spray nozzle in comparison with anti-solvent crystallization. In this study, the fabrication of inorganic-organic composite particles using a coaxial tube reactor on the liquid-liquid interfacial crystallization is proven successful. These findings suggest that liquid-liquid interfacial crystallization is a promising means of efficiently producing composite particles because of their applicability to infusion in various processes.

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“…Kawashima et al studied the SA and the QESD mechanisms in detail for the agglomeration of ascorbic acid 16 and bucillamine. 17 The solvent systems were composed in two different ways for the agglomeration.…”

Section: Introductionmentioning

confidence: 99%

Preparation of spherical agglomerates from potash alum

et al. 2016

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Development of Agglomerated Crystals of Ascorbic Acid by the Spherical Crystallization Technique for Direct Tableting, and Evaluation of Their Compactibilities [Translated]<sup>†</sup>

Cited by 13 publications

References 8 publications

Biodegradable PLGA Microsphere Formation Mechanisms in Electrosprayed Liquid Droplets

Biodegradable PLGA Microsphere Formation Mechanisms in Electrosprayed Liquid Droplets

Particle Preparation and Morphology Control with Mutual Diffusion Across Liquid-Liquid Interfaces

Preparation of spherical agglomerates from potash alum

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