Development of Adrenergic and Dopamine Receptors in the Kidney
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Cited by 5 publications
References 21 publications
The sections in this article are: Historical Perspective Standards of Reference for Comparison of Renal Function Between Infants and Adults Morphogenesis of the Kidney Embryologic Origin of the Kidney Subsequent Development of the Kidney Glomerulus Renal Tubule Renal Blood Flow and its Control During Development Total Renal Blood Flow Intrarenal Distribution of Blood Flow Renal Microvasculature Control of Renal Circulation Glomerular Filtration Net Ultrafiltration Pressure Hydraulic Conductivity and Ultrafiltration Coefficient Glomerular Capillary Surface Area Factors That Affect GFR during Development Autoregulation of GFR Renal Energy Metabolism Development of Renal Cortical Metabolic Pathways Tubular Functions Renal Reabsorption of Sodium Reabsorption of Bicarbonate and Excretion of Hydrogen Ions Glucose Transport Transport of Amino Acids Transport of Organic Acids Phosphate Transport Control of Renal Transport during Development Calcium Transport Magnesium Transport Potassium Transport Concentration of Urine Developmental Renal Physiology as A Tool for Understanding the Emergence and Integration of Renal Transport Systems
The sections in this article are: Historical Perspective Standards of Reference for Comparison of Renal Function Between Infants and Adults Morphogenesis of the Kidney Embryologic Origin of the Kidney Subsequent Development of the Kidney Glomerulus Renal Tubule Renal Blood Flow and its Control During Development Total Renal Blood Flow Intrarenal Distribution of Blood Flow Renal Microvasculature Control of Renal Circulation Glomerular Filtration Net Ultrafiltration Pressure Hydraulic Conductivity and Ultrafiltration Coefficient Glomerular Capillary Surface Area Factors That Affect GFR during Development Autoregulation of GFR Renal Energy Metabolism Development of Renal Cortical Metabolic Pathways Tubular Functions Renal Reabsorption of Sodium Reabsorption of Bicarbonate and Excretion of Hydrogen Ions Glucose Transport Transport of Amino Acids Transport of Organic Acids Phosphate Transport Control of Renal Transport during Development Calcium Transport Magnesium Transport Potassium Transport Concentration of Urine Developmental Renal Physiology as A Tool for Understanding the Emergence and Integration of Renal Transport Systems
The present review summarizes recent studies describing the role of renal sympathetic innervation in the regulation of renal function during development. The afferent renal innervation appears early during fetal life and probably precedes the development of efferent renal nerves. There is suggestive evidence that renal nerves are required for the proper development of the kidney and that neurotrophic growth factors play an important role in renal embryogenesis and in renal tubular differentiation. Renal sympathetic innervation modulates renal hemodynamics early during development. Renal nerve stimulation during alpha-adrenoceptor blockade produces renal vasodilation in fetal and newborn animals but not in adults. Unlike the effect of renal nerves on fetal renal hemodynamics which is observed in the young fetus, the role of renal sympathetic nerves in modulating fluid and electrolyte homeostasis seems to develop during late gestation. Recent studies have also shown that renal nerves play an important role in regulating renin secretion during the transition from fetal to newborn life. For example, renal denervation during fetal life suppressed the physiological rise in plasma renin activity associated with delivery and decreased renal renin mRNA levels after birth. Taken together, these studies suggest that renal nerves influence fetal renal development and that the influence of renal sympathetic innervation on renal hemodynamics and function changes with maturation.
The renal vasodilatory response to beta-2 adrenoceptor stimulation is greater in fetal than adult sheep. Since this phenomenon could not be explained by differences in cAMP-mediated events, we examined the ontogeny of renal beta adrenoceptor subtypes by radioligand binding using the beta adrenergic antagonist 125I-pindolol. The specific binding of 125I-pindolol was saturable, reversible, and stereoselective. Competition studies using the selective beta-1 and beta-2 adrenergic antagonists (ICI 89406 and ICI 118551, respectively) revealed two beta adrenoceptor subtypes in adult kidneys but only the beta-2 subtype in fetal kidneys. Preincubation of renal cortical membranes with either the beta-1 or the beta-2 adrenergic antagonist prior to competition studies in adult kidneys decreased specific binding and resulted in the detection of only one beta adrenoceptor subtype. Preincubation of fetal kidneys with the beta-1 adrenergic antagonist did not affect binding characteristics; preincubation of fetal kidneys with the beta-2 adrenergic antagonist markedly decreased specific binding from 64 +/- 2% (n = 4) to 29 +/- 2% (n = 3) (P less than 0.05). Analysis of Rosenthal plots revealed similar beta adrenoceptor densities and affinities between fetal and adult kidneys.(ABSTRACT TRUNCATED AT 250 WORDS)
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