Development of activity of lymphocytes estimated from nucleolar morphology in infants

The cellular immune response (MIF, E-rosette formation and changes in nucleolar morphology of lymphocytes) was followed as related to age and antigenic stimulation. MIF in healthy infants increased from the 2nd to the 12th week of life as compared with the first week, probably due to BCG vaccination. The total and active E-rosette formation did not change during the whole period of investigation. Ring-shaped nucleoli increased gradually from the second week of life. Active nucleoli increased up to the 4th week, i.e. after BCG vaccination and then slowly decreased. Micronucleoli being high in the first week, decreased during 24 weeks of life. After artificial colonization of the intestine the production of MIF was slightly lower in colonized infants than in controls from the 2nd to the 12th week. The other parameters followed were not influenced by colonization.

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Some cellular immune reactions in infants. MIF, E-rosette formation and changes in nucleolar morphology

Lodinová

Haníková

Jouja

1980

Folia Microbiol

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Development of activity of lymphocytes estimated from nucleolar morphology in infants

Abstract: Changes in nucleolar morphology of the lymphocytes were studied in peripheral blood smears of infants from birth up to one year of life. A marked proportional increase of lymphocytes with active nucleoli was found during the first month.

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Some cellular immune reactions in infants. MIF, E-rosette formation and changes in nucleolar morphology

Some cellular immune reactions in infants. MIF, E-rosette formation and changes in nucleolar morphology

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