Development of acquired von Willebrand's disease after mixed connective tissue disease

Yoshida, Hiromichi; Arai, K.; Wakashin, M

doi:10.1016/0002-9343(88)90607-9

Cited by 18 publications

(15 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All the different subtypes of VWD are represented in AVWD associated with autoantibodies (43). AVWD is also reported in other autoimmune disorders, like scleroderma (57), and mixed connective tissue disease (58). Other diseases associated with antibodies are monoclonal gammopathies (43), multiple myeloma (22), Waldenstrom's macroglobulinemia (59), chronic myeloid leukemia (60), and angiodysplasia (61).…”

Section: Immune-mediated Etiologymentioning

confidence: 99%

Pathophysiology of acquired von Willebrand disease: a concise review

Shetty

Kasatkar

Ghosh

2011

European Journal of Haematology

View full text Add to dashboard Cite

Acquired von Willebrand disease (AVWD) is a rare, underdiagnosed hemorrhagic disorder, which is similar to congenital VWD with regard to the clinical and laboratory parameters; however, it is found in individuals with no positive family history and has no genetic basis. The etiology is varied, the commonest being hematoproliferative disorders and cardiovascular disorders. Other disorders associated with AVWD are autoimmune disorders such as systematic lupus erythematosus, hypothyroidism, and neoplasia, or it may also be drug induced. In quite a few cases, the etiology is unknown. The pathogenic mechanisms are different in different underlying disorders or they may be overlapping among these disorders. Some of the proposed mechanisms include the development of autoantibodies, selective absorption of high molecular weight von Willebrand factor (VWF) multimers, non‐selective absorption of VWF, mechanical destruction of VWF under high shear stress, and increased proteolysis. This report presents a concise review of the pathophysiological mechanisms of AVWD in these various underlying conditions.

show abstract

Section: Immune-mediated Etiologymentioning

confidence: 99%

Pathophysiology of acquired von Willebrand disease: a concise review

Shetty

Kasatkar

Ghosh

2011

European Journal of Haematology

View full text Add to dashboard Cite

show abstract

“…AvWD, as opposed to cvWD, has an onset late in life and occurs concomitantly with immunoproliferative disorders such as lymphomas, leukemias, myelomas, or autoimmune disorders. [6][7][8][9][10][11][12][13] It has been reported, in cases of thalassemia, Waldenstrom's macroglobulinemia, monoclonal gammopathy of undetermined significance (MGUS), Wilms' tumors, hypothyroidism, hairy cell leukemia, angiodysplasia, and gastrointestinal telangiectasia. 10,[14][15][16][17][18][19][20] The key to avWD is its late onset bleeding diathesis with a negative family history and no prior history of prolonged bleeding.…”

Section: Clinical Featuresmentioning

confidence: 99%

Acquired von Willebrand's Disease in Malignancy

Jakway¹

1992

Semin Thromb Hemost

View full text Add to dashboard Cite

“…The second most common groups of disorders associated with aVWS is neoplasia, including Wilms tumors [52][53][54][55][56][57] and carcinomas [58,59], followed by immunological diseases, most notably SLE [14,60,61] and hypothyroidism [62][63][64][65][66][67][68][69][70][71][72][73][74][75]. Various other clinical conditions (Table I), such as rare immunological disorders [76][77][78][79], cardiovascular diseases [80][81][82][83][84][85][86][87], treatments using antibiotics [88][89][90], anticonvulsants [91], plasma volume expander [92][93][94] or recombinant factor VIII infusion [95], uremia [96][97]…”

Section: Associated Disorders and Pathogenic Mechanismsmentioning

confidence: 99%

Acquired von Willebrand syndrome: An update

Franchini

Lippi

2006

American J Hematol

View full text Add to dashboard Cite

Acquired von Willebrand syndrome (aVWS) is a rare bleeding disorder with laboratory findings similar to those for congenital von Willebrand disease (VWD). However, unlike congenital VWD, it arises in individuals with no personal or family history of bleeding. aVWS occurs in association with a variety of underlying disorders, most frequently in lymphoproliferative disorders, myeloproliferative disorders, and cardiovascular diseases. Through an analysis of the more recent literature data, the pathophysiology and the clinical, laboratory, and therapeutic aspects of this syndrome are concisely reported in this review. Am. J. Hematol. 82:368-375, 2007. V V C 2006 Wiley-Liss, Inc.

show abstract

Development of acquired von Willebrand's disease after mixed connective tissue disease

Cited by 18 publications

References 6 publications

Pathophysiology of acquired von Willebrand disease: a concise review

Pathophysiology of acquired von Willebrand disease: a concise review

Acquired von Willebrand's Disease in Malignancy

Acquired von Willebrand syndrome: An update

Contact Info

Product

Resources

About