Development of a β-cyclodextrin-modified gold nanoparticle-assisted electromembrane extraction method followed by capillary electrophoresis for methadone determination in plasma

Hoseininezhad-Namin, Mir Saleh; Özkan, Síbel A.; Rahimpour, Elaheh; Jouyban, Abolghasem

doi:10.1039/d2ra06419g

Cited by 9 publications

(2 citation statements)

References 49 publications

(51 reference statements)

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“…11,12 Nanoparticles (NPs) with high atomic numbers as radiation sensitizers such as silver, bismuth, platinum, gold, etc., has made it possible to solve major problems of RT. [13][14][15] Indeed, gold nanoparticles (AuNPs) are the most promising platform to diagnose and treat tumors. Its easy surface modification, unique optical properties, high biocompatibility, and small size favor extravasation and access to the tumor microenvironment.…”

Section: Introductionmentioning

confidence: 99%

“…In order to increase the quality of the destructive effect of RT, scientists use radiation sensitizers 11,12 . Nanoparticles (NPs) with high atomic numbers as radiation sensitizers such as silver, bismuth, platinum, gold, etc., has made it possible to solve major problems of RT 13–15 . Indeed, gold nanoparticles (AuNPs) are the most promising platform to diagnose and treat tumors.…”

Section: Introductionmentioning

confidence: 99%

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Methotrexate conjugated polymeric prodrug encapsulating gold nanoparticles for combined chemo/radiation therapies

Hooshyar,

Mohammadi,

Ghorbani

et al. 2024

Applied Organom Chemis

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Among the potent anticancer agents, methotrexate (MTX) is very effective against many different types of cancer cells. Implementation of chemotherapy along with radiotherapy, known as synchronous chemoradiotherapy, can augment the treatment efficacy. In the present study self‐assembled MTX conjugated mPEG‐PCL copolymer encapsulating gold nanoparticles (AuNPs) hybrid (mPEG‐PCL‐MTX@Au) was developed as both drug carrier and radiosensitizer. After successful synthesis and characterization of hybrids with different techniques such as hydrogen nuclear magnetic resonance (HNMR), Fourier transform infrared spectroscopy (FTIR), ultraviolet–visible (UV‐Vis), x‐ray diffraction analysis (XRD), dynamic light scattering (DLS), and transmission electron microscopy (TEM). The anticancer activity of designed system was evaluated with a series of biological assays. TEM image indicate that AuNPs encapsulated by self‐assembled mPEG‐PCL‐MTX NPs. It was found that the micelle of that shown in the TEM image contains nine gold nanoparticles (NPs). The hydrodynamic diameter of mPEG‐PCL‐MTX@Au was 81.40 ± 8 nm. As a result, at acidic pH, which simulates tumor tissue, the most drug release is done compared to neutral pH conditions, which are the physiological conditions of the body. About 70% of the drug was released in acidic pH, while in alkaline pH, it was about 35%. The effectiveness of cancer treatment was significantly improved by using developed NPs, which introduces simultaneous chemotherapy and radiotherapy. MTT and apoptosis assays show that the mPEG‐PCL‐MTX@Au as the final formulation improves the radiosensitivity of the 4T1 breast cancer cells and also remarkably kills breast cancer. Furthermore, the result revealed that designed hybrid system extremely able to produce reactive oxygen species (ROS) within cancer cells. These results offer powerful evidence for the potential capability of mPEG‐PCL‐MTX@Au in radiosensitization of malignant tumors and opens up a new avenue of research in this area.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Methotrexate conjugated polymeric prodrug encapsulating gold nanoparticles for combined chemo/radiation therapies

Hooshyar,

Mohammadi,

Ghorbani

et al. 2024

Applied Organom Chemis

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Effects of Ge, Si, and B doping on the adsorption and detection properties of C60 fullerene towards methadone in gas and aqua phases: a DFT study

et al. 2023

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Electrochemical determination of Methadone by use of chitosan and carbon nanostructured electrode: application to doping monitoring between athletes in biological and food samples

Ma,

Tian

2023

Food Measure

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Development of a β-cyclodextrin-modified gold nanoparticle-assisted electromembrane extraction method followed by capillary electrophoresis for methadone determination in plasma

Abstract: Gold nanoparticles (AuNPs) modified with β-cyclodextrin (β-CD) were used to assist with electromembrane extraction (EME) and were coupled with capillary electrophoresis (CE) for the extraction and measurement of methadone from plasma samples.

Cited by 9 publications

References 49 publications

Methotrexate conjugated polymeric prodrug encapsulating gold nanoparticles for combined chemo/radiation therapies

Methotrexate conjugated polymeric prodrug encapsulating gold nanoparticles for combined chemo/radiation therapies

Effects of Ge, Si, and B doping on the adsorption and detection properties of C60 fullerene towards methadone in gas and aqua phases: a DFT study

Electrochemical determination of Methadone by use of chitosan and carbon nanostructured electrode: application to doping monitoring between athletes in biological and food samples

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